INT10373

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Context Info
Confidence 0.25
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.97
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ADI1) Golgi apparatus (ADI1) cytoplasm (ADI1)
cytosol (ADI1) oxidoreductase activity (ADI1) nucleolus (ADI1)
Anatomy Link Frequency
chondrocytes 1
photoreceptors 1
ADI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 60 98.52 Very High Very High Very High
Inflammation 24 94.48 High High
fibrosis 8 89.76 High High
Pain 11 88.32 High High
cva 1 84.44 Quite High
headache 2 83.24 Quite High
Potency 2 79.40 Quite High
rheumatoid arthritis 36 73.92 Quite High
Arthritis 6 61.52 Quite High
spinal inflammation 4 41.04 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 112 100.00 Very High Very High Very High
Osteoarthritis 61 98.52 Very High Very High Very High
Blindness 43 98.24 Very High Very High Very High
Autoimmune Disease 76 97.88 Very High Very High Very High
Disease 83 96.88 Very High Very High Very High
INFLAMMATION 24 94.48 High High
Syndrome 2 91.08 High High
Fibrosis 8 89.76 High High
Pain 11 88.32 High High
Respiratory Distress 1 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The correlations of ARD with ANA titer, ANA score, and RF suggest the possibility that auto-immunity could play a role in the progression of ARD.
Gene_expression (progression) of ARD associated with pulmonary disease
1) Confidence 0.25 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 0.81 Pain Relevance 0
If autoimmune responses play a role in the progression of ARD, this would become an important target for therapeutic strategies.
Gene_expression (progression) of ARD associated with pulmonary disease
2) Confidence 0.25 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 0.75 Pain Relevance 0
Alternatively, because there were positive correlations between RF and both ANA titer and ARD, the threshold of asbestos exposure impacting development of RF may simply be too low to be detected using the simplified exposure scale (Table 2).
Gene_expression (titer) of ARD associated with pulmonary disease
3) Confidence 0.25 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 0.70 Pain Relevance 0.17
Exposure and ARD are assumed to be correlated (Peipins et al. 2003), even though this correlation was only at the 90th percentile using our scoring systems.
Gene_expression (Exposure) of ARD associated with pulmonary disease
4) Confidence 0.25 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 0.89 Pain Relevance 0.08
It is safe and highly effective in inducing clinical, morphologic and karyotypic remission with a marked decrease in the expression of the abnormal RAR-message in APL.
Gene_expression (expression) of APL
5) Confidence 0.17 Published 1992 Journal Harefuah Section Abstract Doc Link 1487198 Disease Relevance 0.96 Pain Relevance 0.21
APL1 (aryl hydrocarbon receptor-interacting protein-like 1) is a member of the FK-506-binding protein family that is specifically expressed in retinal photoreceptors.
Gene_expression (expressed) of APL1 in photoreceptors
6) Confidence 0.13 Published 2007 Journal Proteome Sci Section Body Doc Link PMC1821315 Disease Relevance 1.10 Pain Relevance 0
MMP mRNA expression levels were evaluated using quantitative real-time PCR, and MMP protein production levels were evaluated in the culture supernatant using ELISA.
Gene_expression (production) of MMP protein
7) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0
One in vitro study also showed that chondrocytes from 40% of OA cases did not show increased aggrecan core protein levels, and decreased levels of MMP-protein in response to GS treatment (18).
Gene_expression (levels) of MMP-protein in chondrocytes associated with osteoarthritis
8) Confidence 0.01 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529383 Disease Relevance 0.77 Pain Relevance 0.45

General Comments

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