INT103739

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 10.19
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 6
plasma 2
brain 2
striatum 2
nucleus 2
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 51 100.00 Very High Very High Very High
Eae 25 99.84 Very High Very High Very High
depression 30 99.64 Very High Very High Very High
opiate 8 99.42 Very High Very High Very High
withdrawal 9 98.52 Very High Very High Very High
amygdala 81 98.08 Very High Very High Very High
cytokine 78 97.92 Very High Very High Very High
Kappa opioid receptor 50 96.32 Very High Very High Very High
antidepressant 12 95.48 Very High Very High Very High
central sensitization 1 90.08 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 173 99.70 Very High Very High Very High
Depression 30 99.64 Very High Very High Very High
Stress 326 99.62 Very High Very High Very High
Targeted Disruption 134 99.48 Very High Very High Very High
Nociception 2 98.52 Very High Very High Very High
Aggression 114 98.40 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 97.76 Very High Very High Very High
Opiate Addiction 1 84.64 Quite High
Pain 10 83.28 Quite High
Starvation 69 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also decreases CRF expression in the brain.
Negative_regulation (decreases) of Gene_expression (expression) of CRF in brain
1) Confidence 0.59 Published 2010 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 20447436 Disease Relevance 0.67 Pain Relevance 0.28
In postnatal day 8 or 9 mice, prolonged (>4 hr) maternal separation leads to increased stress as indicated by elevated corticosterone and ACTH in the circulation, as well as reduced corticotropin releasing hormone (CRH) expression in the arcuate nucleus of the hypothalamus [10], [17].
Negative_regulation (reduced) of Gene_expression (expression) of CRH in hypothalamus associated with stress
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.35 Pain Relevance 0.03
Based on the published data cited above, we would have expected to see increased Npy and decreased Crh expression in the hypothalami of deprived pups.
Negative_regulation (decreased) of Gene_expression (expression) of Crh
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.23 Pain Relevance 0.03
This cyclic expression of CRH is not abolished in adrenalectomized rats and it is preserved after the constitutive replacement by the corticosterone pellet, indicating that circulating glucocorticoid is not involved in the circadian regulation of CRH (Watts et al. 2004).
Neg (not) Negative_regulation (abolished) of Gene_expression (expression) of CRH
4) Confidence 0.48 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0
Adrenalectomy induces the CRH mRNA expression in the PVN; however, the CRH gene expression was decreased by glucocorticoid replacement (Jingami et al. 1985; Bayer et al. 1988).
Negative_regulation (decreased) of Gene_expression (expression) of CRH gene
5) Confidence 0.48 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.23 Pain Relevance 0
Conditioned fear was decreased 1 h but not 24 h after conditioning in transgenic mice, and immobility was decreased [corrected] in forced swimming in corticotropin-releasing hormone overexpressors.
Negative_regulation (decreased) of Gene_expression (overexpressors) of corticotropin-releasing hormone associated with targeted disruption and anxiety disorder
6) Confidence 0.41 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099906 Disease Relevance 1.14 Pain Relevance 0.23
Moreover, sensorimotor performance on a rotorod was impaired, and water intake was reduced in corticotropin-releasing hormone overproducing mice, while no changes were seen in nociception.
Negative_regulation (reduced) of Gene_expression (overproducing) of corticotropin-releasing hormone associated with nociception
7) Confidence 0.41 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099906 Disease Relevance 1.08 Pain Relevance 0.23
We found that the expression of Crh in hypothalamus was similar in Mecp2?
Negative_regulation (similar) of Gene_expression (expression) of Crh in hypothalamus
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.41 Pain Relevance 0
/y mice, we measured the expression of Crh, a key regulator of the mammalian stress response.
Negative_regulation (measured) of Gene_expression (expression) of Crh associated with stress
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.41 Pain Relevance 0
Such a diminished responsiveness of the HPA axis to stress was assigned to a reduced hypothalamic CRF mRNA expression [44].
Negative_regulation (reduced) of Gene_expression (expression) of CRF mRNA associated with stress
10) Confidence 0.37 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.95 Pain Relevance 0.05
In CRH-BP transgenic animals, the plasma concentration of ACTH and corticosterone is not reduced, despite the abundant expression of CRH-BP in the pituitary (Burrows et al. 1998).
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of CRH in plasma associated with targeted disruption
11) Confidence 0.36 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.22 Pain Relevance 0.12
There is abundant evidence regarding the suppression of CRH and vasopressin gene expression by glucocorticoid.
Negative_regulation (suppression) of Gene_expression (expression) of CRH
12) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.21 Pain Relevance 0
Opiate-withdrawn CRF1-/- mice also showed aberrant CRF and dynorphin expression in the paraventricular nucleus of the hypothalamus (PVN) and the striatum, indicating profound impairments in stress-responsive brain circuitry.
Negative_regulation (showed) of Gene_expression (expression) of CRF in striatum associated with stress, dynorphin and opiate
13) Confidence 0.34 Published 2007 Journal Neuron Section Abstract Doc Link 17296558 Disease Relevance 0.35 Pain Relevance 0.84
Previous findings have indicated that CRF neurotransmission is decreased in association with lactation.
Negative_regulation (decreased) of Gene_expression (neurotransmission) of CRF
14) Confidence 0.33 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.54 Pain Relevance 0
In postnatal day 8 or 9 mice, prolonged (>4 hr) maternal separation leads to increased stress as indicated by elevated corticosterone and ACTH in the circulation, as well as reduced corticotropin releasing hormone (CRH) expression in the arcuate nucleus of the hypothalamus [10], [17].
Negative_regulation (reduced) of Gene_expression (expression) of corticotropin releasing hormone in hypothalamus associated with stress
15) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.35 Pain Relevance 0.03
We then measured CRF-induced EPM behavior and changes in KORp-ir.
Negative_regulation (measured) of Gene_expression (behavior) of CRF-induced
16) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.23 Pain Relevance 0.72
It has previously been speculated that decreased fear and anxiety (possibly via decreased CRF neurotransmission) during lactation may support maternal aggression by increasing the likelihood that a dam will attack a normally fear-evoking stimulus [4,29].
Negative_regulation (decreased) of Gene_expression (neurotransmission) of CRF associated with aggression and anxiety disorder
17) Confidence 0.29 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.86 Pain Relevance 0
Decreased depression-like behavior in ICER-overexpressing rats [46] may, in part, result from reduced CRH production, as the overproduction of CRH is believed to contribute to depression [66, 67].
Negative_regulation (reduced) of Gene_expression (production) of CRH associated with depression
18) Confidence 0.22 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.89 Pain Relevance 0.39
It can reduce the increased levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary, and reverse the decreased glucocorticoid receptor protein expression in the hypothalamus paraventricular nucleus to normal (40).


Negative_regulation (reduce) of Gene_expression (expression) of corticotropin-releasing hormone mRNA in nucleus
19) Confidence 0.02 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816380 Disease Relevance 0.88 Pain Relevance 0.10
Indeed, the application of IL-18 in rat hypothalamic explants decreases basal and KCl-stimulated corticotropin-releasing hormones (CRH), as well as CRH gene expression [81].
Negative_regulation (decreases) of Gene_expression (expression) of CRH gene
20) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.19 Pain Relevance 0.11

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