INT10374

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 22.59
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
Anatomy Link Frequency
thyroid 3
SH-SY5Y 2
CAR 1
liver 1
fibroblasts 1
RARA (Homo sapiens)
RARA - L155V (1)
Pain Link Frequency Relevance Heat
agonist 628 100.00 Very High Very High Very High
Inflammation 202 99.48 Very High Very High Very High
cytokine 91 97.60 Very High Very High Very High
intrathecal 2 96.88 Very High Very High Very High
Codeine 53 95.64 Very High Very High Very High
neuropeptide release 1 93.28 High High
Mechanotransduction 1 92.68 High High
c fibre 7 92.64 High High
opioid receptor 37 91.28 High High
diabetic neuropathy 2 90.16 High High
Disease Link Frequency Relevance Heat
Leukemia 191 100.00 Very High Very High Very High
Diabetes Mellitus 120 100.00 Very High Very High Very High
Neuropathic Pain 8 99.92 Very High Very High Very High
Rheumatoid Arthritis 364 99.78 Very High Very High Very High
Apoptosis 301 99.72 Very High Very High Very High
Myeloid Leukemia 88 99.68 Very High Very High Very High
INFLAMMATION 249 99.48 Very High Very High Very High
Acute Promyelocytic Leukemia 14 99.38 Very High Very High Very High
Neuroblastoma 90 99.28 Very High Very High Very High
Colon Cancer 200 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is safe and highly effective in inducing clinical, morphologic and karyotypic remission with a marked decrease in the expression of the abnormal RAR-message in APL.
Gene_expression (expression) of RAR
1) Confidence 0.75 Published 1992 Journal Harefuah Section Abstract Doc Link 1487198 Disease Relevance 0.96 Pain Relevance 0.21
MKo contributed to the study of RAR or RXR subtype expression and statistical analysis.
Gene_expression (expression) of RAR
2) Confidence 0.68 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.72 Pain Relevance 0.26
Patients with these leukemias display translocations between the PML (promyelocytic leukemia) gene on chromosome 15 and the RARA (retinoic acid receptor ?)
Gene_expression (Patients) of RARA associated with leukemia
3) Confidence 0.59 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 1.43 Pain Relevance 0
Effect of RAR-selective agonists on IL-1-induced expression of IL-6
Gene_expression (agonists) of RAR-selective associated with agonist
4) Confidence 0.59 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.05 Pain Relevance 0.42
, BMS-453 for RAR-?
Gene_expression (for) of RAR
5) Confidence 0.59 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.55
, BMS-453 for RAR-?
Gene_expression (for) of RAR
6) Confidence 0.59 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.15 Pain Relevance 0.57
The sequences of the primers used were IL-6 (sense: 5'-CCGGAGAGGAGACTTCACAG-3', anti-sense: 5'-CCGGAGAGGAGACTTCACAG-3', NM 012589, 161 base pairs [bp], 59°C), RAR-?
Gene_expression (used) of RAR
7) Confidence 0.59 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.04
the generation of the PML/RAR?
Gene_expression (generation) of RAR
8) Confidence 0.54 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.82 Pain Relevance 0
on the expression of RAR and RXR subtypes
Gene_expression (expression) of RAR
9) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.06 Pain Relevance 0.04
Synovial fibroblasts expressed all RAR and RXR subtypes except RXR-?.
Gene_expression (expressed) of RAR in fibroblasts
10) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656246 Disease Relevance 0.15 Pain Relevance 0.25
In summary, the induction of ERK1/2 phosphorylation by ATRA is a RAR-independent key event though which the retinoid increases COX-2 expression and PGE2 production in SH-SY5Y human neuroblastoma cells.
Gene_expression (expression) of RAR in SH-SY5Y associated with neuroblastoma
11) Confidence 0.48 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.24 Pain Relevance 0.08
In summary, the induction of ERK1/2 phosphorylation by ATRA is a RAR-independent key event though which the retinoid increases COX-2 expression and PGE2 production in SH-SY5Y human neuroblastoma cells.
Gene_expression (production) of RAR in SH-SY5Y associated with neuroblastoma
12) Confidence 0.48 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.24 Pain Relevance 0.08
Addition of RXR or RAR
Gene_expression (Addition) of RAR
13) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.90 Pain Relevance 0.04
the generation of the PML/RAR?
Gene_expression (generation) of RAR
14) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.82 Pain Relevance 0
On the other hand, while elevated levels of RAR mRNA expression has also been described in breast, liver and esophageal tumors [53,63,64], mechanism and significance are unknown.
Gene_expression (expression) of RAR mRNA in liver associated with esophageal cancer
15) Confidence 0.45 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 1.00 Pain Relevance 0
Nevertheless, if the expression of RAR correlates with tissue sensitivity to retinoids, our results should be confirmed within a larger number of samples and both the mechanism leading to inappropriate RXR and RAR expression and the response of CRC to retinoids should be investigated.
Gene_expression (expression) of RAR associated with colon cancer
16) Confidence 0.45 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 1.10 Pain Relevance 0
Nevertheless, if the expression of RAR correlates with tissue sensitivity to retinoids, our results should be confirmed within a larger number of samples and both the mechanism leading to inappropriate RXR and RAR expression and the response of CRC to retinoids should be investigated.
Gene_expression (expression) of RAR associated with colon cancer
17) Confidence 0.45 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 1.17 Pain Relevance 0
We have recently demonstrated that exogenous expression of RAR?
Gene_expression (expression) of RAR
18) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.75 Pain Relevance 0.03
Similar results were obtained after treatment with RA that did not alter the activity of the prodynorphin promoter even after the overexpression of RAR (Figure 8B).
Gene_expression (overexpression) of RAR associated with rheumatoid arthritis
19) Confidence 0.44 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.10 Pain Relevance 0
Figure 6 shows that although wild-type DREAM causes activation of the DR3- and DR5-containing promoters, DREAM mutants bearing the mutations L47,52V in the first LCD or L155V in the second LCD did not activate basal or ligand-dependent expression of the DR3 and RAR?
Gene_expression (expression) of RAR (L155V)
20) Confidence 0.44 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0

General Comments

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