INT103740

Context Info Confidence 0.32 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.40 Pain Relevance 2.84

cytoplasm (Vta1)

Anatomy Link Frequency nucleus accumbens 3 striatum 3 Vta1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 55 100.00 Nucleus accumbens 26 100.00 Ventral tegmentum 23 100.00 Nicotine 278 99.90 addiction 68 96.60 GABAergic 4 95.76 depression 1 95.08 Cannabinoid receptor 3 91.52 tetrodotoxin 1 84.36 Eae 10 83.44

Disease Link Frequency Relevance Heat Drug Dependence 40 96.60 Depression 1 95.08 Sprains And Strains 2 55.52 Nicotine Addiction 38 5.00 Opiate Addiction 12 5.00 Syndrome 12 5.00 Recurrence 8 5.00 Tremor 6 5.00 Sleep Disorders 4 5.00 Ocular Toxicity (including Many Sub-types) 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Accordingly, dopamine release in the projection region of VTA neurons, the nucleus accumbens, would also increase.

Positive_regulation (increase) of Localization (release) of VTA in nucleus accumbens associated with nucleus accumbens, ventral tegmentum and dopamine

1) Confidence 0.32 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099913 Disease Relevance 0.10 Pain Relevance 0.89

Research to date does suggest an interaction between central nicotinic and dopaminergic systems.38 Evidence implicating dopamine in behavioral effects of nicotine addiction has come from studies utilizing the neurotoxin 6-hydroxydopamine to produce lesions of forebrain dopamine systems.39 In vitro and in vivo studies show that nicotine can stimulate the release of dopamine in the ventral tegmental area (VTA), striatum, and nucleus accumbens.40,41 These effects of nicotine also show some selectivity for the mesolimbic as compared with the nigrostriatal branch of the dopamine system.

Positive_regulation (stimulate) of Localization (release) of VTA in striatum associated with nucleus accumbens, ventral tegmentum, addiction, dopamine and nicotine

2) Confidence 0.03 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0.15 Pain Relevance 0.97

Research to date does suggest an interaction between central nicotinic and dopaminergic systems.38 Evidence implicating dopamine in behavioral effects of nicotine addiction has come from studies utilizing the neurotoxin 6-hydroxydopamine to produce lesions of forebrain dopamine systems.39 In vitro and in vivo studies show that nicotine can stimulate the release of dopamine in the ventral tegmental area (VTA), striatum, and nucleus accumbens.40,41 These effects of nicotine also show some selectivity for the mesolimbic as compared with the nigrostriatal branch of the dopamine system.

Positive_regulation (stimulate) of in nucleus accumbens Localization (release) of VTA in striatum associated with nucleus accumbens, ventral tegmentum, addiction, dopamine and nicotine

3) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0.15 Pain Relevance 0.97

General Comments

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