INT103740

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.40
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Vta1)
Anatomy Link Frequency
nucleus accumbens 3
striatum 3
Vta1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 55 100.00 Very High Very High Very High
Nucleus accumbens 26 100.00 Very High Very High Very High
Ventral tegmentum 23 100.00 Very High Very High Very High
Nicotine 278 99.90 Very High Very High Very High
addiction 68 96.60 Very High Very High Very High
GABAergic 4 95.76 Very High Very High Very High
depression 1 95.08 Very High Very High Very High
Cannabinoid receptor 3 91.52 High High
tetrodotoxin 1 84.36 Quite High
Eae 10 83.44 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 40 96.60 Very High Very High Very High
Depression 1 95.08 Very High Very High Very High
Sprains And Strains 2 55.52 Quite High
Nicotine Addiction 38 5.00 Very Low Very Low Very Low
Opiate Addiction 12 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low
Tremor 6 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, dopamine release in the projection region of VTA neurons, the nucleus accumbens, would also increase.
Positive_regulation (increase) of Localization (release) of VTA in nucleus accumbens associated with nucleus accumbens, ventral tegmentum and dopamine
1) Confidence 0.32 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099913 Disease Relevance 0.10 Pain Relevance 0.89
Research to date does suggest an interaction between central nicotinic and dopaminergic systems.38 Evidence implicating dopamine in behavioral effects of nicotine addiction has come from studies utilizing the neurotoxin 6-hydroxydopamine to produce lesions of forebrain dopamine systems.39 In vitro and in vivo studies show that nicotine can stimulate the release of dopamine in the ventral tegmental area (VTA), striatum, and nucleus accumbens.40,41 These effects of nicotine also show some selectivity for the mesolimbic as compared with the nigrostriatal branch of the dopamine system.
Positive_regulation (stimulate) of Localization (release) of VTA in striatum associated with nucleus accumbens, ventral tegmentum, addiction, dopamine and nicotine
2) Confidence 0.03 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0.15 Pain Relevance 0.97
Research to date does suggest an interaction between central nicotinic and dopaminergic systems.38 Evidence implicating dopamine in behavioral effects of nicotine addiction has come from studies utilizing the neurotoxin 6-hydroxydopamine to produce lesions of forebrain dopamine systems.39 In vitro and in vivo studies show that nicotine can stimulate the release of dopamine in the ventral tegmental area (VTA), striatum, and nucleus accumbens.40,41 These effects of nicotine also show some selectivity for the mesolimbic as compared with the nigrostriatal branch of the dopamine system.
Positive_regulation (stimulate) of in nucleus accumbens Localization (release) of VTA in striatum associated with nucleus accumbens, ventral tegmentum, addiction, dopamine and nicotine
3) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0.15 Pain Relevance 0.97

General Comments

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