INT103755

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.64
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
salivary glands 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 99.84 Very High Very High Very High
Inflammation 49 99.62 Very High Very High Very High
tolerance 6 92.96 High High
psoriasis 3 88.96 High High
rheumatoid arthritis 6 86.84 High High
cytokine 42 80.08 Quite High
Antinociceptive 1 70.40 Quite High
Potency 2 47.76 Quite Low
antagonist 19 32.76 Quite Low
corticosteroid 13 12.88 Low Low
Disease Link Frequency Relevance Heat
Salivary Gland Disease 2 99.92 Very High Very High Very High
INFLAMMATION 47 99.62 Very High Very High Very High
Repression 1 99.10 Very High Very High Very High
Cytomegalovirus Infection 10 98.52 Very High Very High Very High
Infection 50 90.64 High High
Psoriasis 3 88.96 High High
Hepatitis 1 87.88 High High
Rheumatoid Arthritis 6 86.84 High High
Disease 17 85.96 High High
Pulmonary Disease 107 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of the IL-10R resulted in a significant decrease in the titer of MCMV in the salivary glands with a concurrent increase in the frequency of IFN?
Positive_regulation (resulted) of Negative_regulation (Blockade) of IL-10R in salivary glands associated with salivary gland disease and cytomegalovirus infection
1) Confidence 0.49 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 1.37 Pain Relevance 0
The pretreatment with naltrexone at doses up to 20 mg/Kg did not prevent the decrease of IL-10 and IL-12 induced by morphine.
Positive_regulation (induced) of Negative_regulation (decrease) of IL-10 associated with morphine
2) Confidence 0.45 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 12101261 Disease Relevance 0 Pain Relevance 0.96
Repression of these pro-inflammatory genes is probably due to the inhibitory effect of IL-10 on activation of the transcription factor nuclear factor-?
Spec (probably) Positive_regulation (due) of Negative_regulation (effect) of IL-10 associated with inflammation and repression
3) Confidence 0.08 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.26 Pain Relevance 0.44

General Comments

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