INT103757

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Context Info
Confidence 0.55
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 37
Total Number 39
Disease Relevance 21.62
Pain Relevance 16.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
dendritic cells 4
Th1 cells 1
Th17 cells 1
plaque 1
platelet 1
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 679 100.00 Very High Very High Very High
Inflammation 485 99.84 Very High Very High Very High
Delta-9-tetrahydrocannabinol 27 99.82 Very High Very High Very High
withdrawal 48 99.80 Very High Very High Very High
Morphine 126 99.68 Very High Very High Very High
agonist 98 99.64 Very High Very High Very High
psoriasis 602 99.44 Very High Very High Very High
antagonist 70 97.84 Very High Very High Very High
mu opioid receptor 7 97.04 Very High Very High Very High
Cannabinoid receptor 12 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thyroid Disease 10 100.00 Very High Very High Very High
Graves' Ophthalmopathy 6 100.00 Very High Very High Very High
INFLAMMATION 498 99.84 Very High Very High Very High
Infection 245 99.70 Very High Very High Very High
Parasitemia 14 99.48 Very High Very High Very High
Psoriasis 723 99.44 Very High Very High Very High
Cancer 347 99.20 Very High Very High Very High
Myocarditis 2 98.32 Very High Very High Very High
Candida Infection 13 97.92 Very High Very High Very High
Disease 628 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pretreatment with naltrexone at doses up to 20 mg/kg did not prevent the decrease of IL-10 and IL-12 induced by morphine.
Negative_regulation (decrease) of IL-12 associated with morphine
1) Confidence 0.55 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.98
One hour after the acute administration of 5, 10, and 20 mg/kg of morphine a dose-related decrease of both IL-10 and IL-12 levels was present.
Negative_regulation (decrease) of IL-12 associated with morphine
2) Confidence 0.55 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.89
The pretreatment with naltrexone at doses up to 20 mg/Kg did not prevent the decrease of IL-10 and IL-12 induced by morphine.
Negative_regulation (decrease) of IL-12 associated with morphine
3) Confidence 0.55 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 12101261 Disease Relevance 0 Pain Relevance 0.95
One hour after the acute administration of 5, 10, and 20 mg/Kg morphine, a dose-related decrease of IL-10 and IL-12 levels was present.
Negative_regulation (decrease) of IL-12 associated with morphine
4) Confidence 0.55 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 12101261 Disease Relevance 0 Pain Relevance 0.91
Morphine withdrawal sensitizes mice to lipopolysaccharide: elevated TNF-alpha and nitric oxide with decreased IL-12.
Negative_regulation (decreased) of IL-12 associated with withdrawal and morphine
5) Confidence 0.44 Published 2005 Journal J. Neuroimmunol. Section Title Doc Link 15913793 Disease Relevance 0 Pain Relevance 0.71
Morphine-withdrawn LPS-treated animals had elevated serum TNF-alpha and nitric oxide levels, and depressed IL-12 levels compared to controls.
Negative_regulation (depressed) of IL-12 associated with morphine
6) Confidence 0.44 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15913793 Disease Relevance 0 Pain Relevance 0.70
Delta-9-tetrahydrocannabinol (THC) injection suppresses serum interleukin-12 (IL-12) levels in Legionella pneumophila-infected mice.
Negative_regulation (suppresses) of interleukin-12 associated with delta-9-tetrahydrocannabinol
7) Confidence 0.40 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443217 Disease Relevance 0.14 Pain Relevance 0.39
Delta-9-tetrahydrocannabinol (THC) injection suppresses serum interleukin-12 (IL-12) levels in Legionella pneumophila-infected mice.
Negative_regulation (suppresses) of IL-12 associated with delta-9-tetrahydrocannabinol
8) Confidence 0.40 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443217 Disease Relevance 0.14 Pain Relevance 0.39
Since the drugs reduce circulating IL-12 levels in patients with Graves' hyperthyroidism, the effect of propylthiouracil on CD1a expression in psoriatic lesions was examined in biopsy samples of patients with plaque psoriasis.
Spec (examined) Negative_regulation (reduce) of IL-12 in plaque associated with psoriasis, thyroid disease and graves' ophthalmopathy
9) Confidence 0.37 Published 2003 Journal BMC Dermatol Section Abstract Doc Link PMC169161 Disease Relevance 0.78 Pain Relevance 0.21
IL-12 levels are also significantly raised in patients with Graves' hyperthyroidism and are reduced following treatment with propylthiouracil [23].
Negative_regulation (reduced) of IL-12 associated with thyroid disease and graves' ophthalmopathy
10) Confidence 0.37 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 1.00 Pain Relevance 0.22
Significantly, elevated levels of colonic RNA for pro-inflammatory cytokines interleukin (IL)-6 and IL-12 were also decreased toward normal with NTX.
Negative_regulation (decreased) of IL-12 associated with inflammation and cytokine
11) Confidence 0.34 Published 2008 Journal J Immunotoxicol Section Abstract Doc Link 18569389 Disease Relevance 1.60 Pain Relevance 0.74
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Negative_regulation (decreased) of IL-12 in Spleen associated with withdrawal
12) Confidence 0.28 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.50
In contrast, other mutations that decrease IL-23 or IL-12 will give protection from psoriasis.27–29 Altogether, these findings indicate that genes participating in IL-12/23 signaling play a significant role in the pathogenesis of chronic epithelial inflammation as seen in psoriasis.
Negative_regulation (decrease) of IL-12 associated with psoriasis and inflammation
13) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.09 Pain Relevance 0.48
These results suggest that THC-induced suppression of serum IL-12 is partly due to a suppression of IL-12 production by dendritic cells and that G(i) signaling and cannabinoid receptors, but not TRPV1, are involved in this suppressive effect.
Negative_regulation (suppression) of IL-12 in dendritic cells associated with cannabinoid receptor and delta-9-tetrahydrocannabinol
14) Confidence 0.25 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443217 Disease Relevance 0.24 Pain Relevance 0.86
Blockade of IL-12/IL-23 was achieved using rat anti–mouse p40 mAb (c17.8; donated by G.
Negative_regulation (Blockade) of IL-12
15) Confidence 0.22 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.81 Pain Relevance 0.10
First, substitution of prostaglandin E2 (PGE2) for ATP in the dendritic cell system produces a similar outcome with respect to inhibition of IL-12 and augmention of IL-23 output [63, 65].
Negative_regulation (inhibition) of IL-12 in dendritic cell
16) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.13
Finally, an oral IL-12/23 inhibitor has been tested in early clinical trials in Crohn’s disease.43
Negative_regulation (inhibitor) of IL-12 associated with disease
17) Confidence 0.20 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.46 Pain Relevance 0.22
This agent is a fully human IgG1 monoclonal antibody that binds to the p40 subunit of IL-12 and IL-23, and prevents their interaction with IL-12R?
Negative_regulation (p40 subunit) of IL-12
18) Confidence 0.20 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.87 Pain Relevance 0.27
It is also possible that ustekinumab treatment does not confer complete inhibition of IL-12/23p40, as is observed with genetic deficiencies.
Negative_regulation (inhibition) of IL-12
19) Confidence 0.20 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.81 Pain Relevance 0.12
A major finding from these studies was that IL-12 was decreased following withdrawal, and it was concluded that this decrease may be a mechanism by which morphine withdrawal is mediating Th2 polarization.
Negative_regulation (decreased) of IL-12 associated with withdrawal and morphine
20) Confidence 0.20 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.88

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