INT103760

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 16.26
Pain Relevance 5.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 4
plasma 2
brain 2
spleen 2
Kupffer cells 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 105 100.00 Very High Very High Very High
agonist 76 100.00 Very High Very High Very High
chemokine 67 99.80 Very High Very High Very High
Morphine 38 99.72 Very High Very High Very High
cytokine 444 99.68 Very High Very High Very High
Inflammation 472 99.40 Very High Very High Very High
Angina 17 95.52 Very High Very High Very High
tolerance 17 95.08 Very High Very High Very High
sodium channel 5 92.32 High High
lidocaine 13 89.92 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 211 100.00 Very High Very High Very High
Death 72 100.00 Very High Very High Very High
INFLAMMATION 598 99.98 Very High Very High Very High
Frailty 134 98.40 Very High Very High Very High
Injury 120 97.88 Very High Very High Very High
Adenocarcinoma 36 97.44 Very High Very High Very High
Sepsis 285 97.20 Very High Very High Very High
Paralysis 5 96.32 Very High Very High Very High
Acute Coronary Syndrome 18 95.92 Very High Very High Very High
Hypertension 3 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fold changes in TLR2 and TLR4 levels with HSP70 stimulation were higher in patients with AMI (both local and systemic samples) compared with patients with SA and controls (Figure 4).
Regulation (changes) of Gene_expression (levels) of TLR4
1) Confidence 0.59 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.08 Pain Relevance 0
While these effects are known for years, Methe et al. only recently reported an effect of statins on TLR4 expression [73].
Regulation (effect) of Gene_expression (expression) of TLR4
2) Confidence 0.53 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.32 Pain Relevance 0.68
Therefore, these results suggest that the Tlr4 mutation in HeJ mice relative to OuJ mice did not affect the HR regulatory adaptive mechanisms associated with O3 or CB exposure.
Neg (not) Regulation (affect) of Gene_expression (mutation) of Tlr4
3) Confidence 0.43 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2516564 Disease Relevance 0.55 Pain Relevance 0
In contrast to younger mice, inflammation in aged MPSIIIB mice was not affected by TLR4/MyD88 deficiency.


Neg (not) Regulation (affected) of Gene_expression (deficiency) of TLR4 associated with inflammation
4) Confidence 0.40 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2396504 Disease Relevance 1.00 Pain Relevance 0.23
To further investigate this latter effect, Lee et al demonstrated that it attenuates the up-regulation of TLR4 expression, NF-?
Regulation (regulation) of Gene_expression (expression) of TLR4
5) Confidence 0.39 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.41 Pain Relevance 0.43
Hence, chloroquine may act at 2 different levels: down-regulation of TLR4 expression and interfering with the intracellular trafficking of LPS through its action on TLR9.
Regulation (regulation) of Gene_expression (expression) of TLR4
6) Confidence 0.39 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.88 Pain Relevance 0.21
Effect of LPS administration on blood pressure
Regulation (Effect) of Gene_expression (administration) of LPS in blood
7) Confidence 0.38 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1177942 Disease Relevance 0 Pain Relevance 0
In particular, TLR4 expression is required on bone marrow-derived cells and on liver parenchymal cells to detect systemic and remote organ response to hemorrhagic shock [8].
Regulation (required) of Gene_expression (expression) of TLR4 in parenchymal cells associated with hemorrhagic shock
8) Confidence 0.31 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.46 Pain Relevance 0.11
Taken together, these experimental data suggest that EGCG selectively inhibits LPS-induced release of HMGB1, TNF, IL-6, IL-12, and chemokines, without affecting LPS-induced release of G-CSF, P-selection, LIX, IL-1?
Neg (without) Regulation (affecting) of Gene_expression (selection) of LPS associated with chemokine
9) Confidence 0.28 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.07 Pain Relevance 0.29
The IL-10 response in serum of GF mice was responsible for the enhanced response of Kupffer cells to LPS (Fig. 2).
Regulation (responsible) of Gene_expression (response) of LPS in Kupffer cells
10) Confidence 0.27 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.05 Pain Relevance 0.15
The changes of expressions of TLR4 on peripheral blood monocytes, TNF-?
Regulation (changes) of Gene_expression (expressions) of TLR4 in monocytes
11) Confidence 0.26 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 1.14 Pain Relevance 0.18
In an attempt to identify possible mechanisms by which feeding WD might enhance the inflammatory response to CLP we examined the influence of WD on TLR-4 expression.
Spec (examined) Regulation (influence) of Gene_expression (expression) of TLR-4 associated with inflammatory response
12) Confidence 0.26 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.37 Pain Relevance 0.23
Following stimulation for 6 h at different LPS concentrations, NF-?
Regulation (different) of Gene_expression (concentrations) of LPS
13) Confidence 0.24 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.05 Pain Relevance 0.23
In this study, we investigated the capacity of in vivo acute and chronic morphine treatment to modulate interleukin (IL)-10 and IL-12 production by LPS and interferon-gamma-stimulated resident and thioglycollate-elicited murine peritoneal macrophages and the development of tolerance to these effects.
Regulation (modulate) of Gene_expression (production) of LPS in peritoneal macrophages associated with tolerance and morphine
14) Confidence 0.24 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 12101261 Disease Relevance 0 Pain Relevance 0.62
The purpose of this paper is to focus on the recent data of various drugs targeting TLR4 expression and pathway and their potential role as adjunctive therapy in severe sepsis and septic shock.


1.

Regulation (targeting) of Gene_expression (expression) of TLR4 associated with sepsis
15) Confidence 0.23 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2855078 Disease Relevance 0.75 Pain Relevance 0.09
Many studies have documented capacities of new drugs to regulate TLR4 signalling and expression.
Regulation (regulate) of Gene_expression (expression) of TLR4
16) Confidence 0.23 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.45 Pain Relevance 0.10
, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12p70, IL-17, GM-CSF, KC, and RANTES induction discriminate between the effects of BCG relative to the inflammatory responses obtained with LPS and TNF-?
Regulation (responses) of Gene_expression (obtained) of LPS associated with chemokine and inflammatory response
17) Confidence 0.20 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.36 Pain Relevance 0.69
Many phagocytic receptors on macrophages had been described, but none of these was responsible for the biological properties of LPS [59].
Regulation (responsible) of Gene_expression (properties) of LPS in macrophages
18) Confidence 0.19 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.65 Pain Relevance 0.05
Protective effect of adrenergic agonists on neuronal death following lipopolysaccharide exposure and oxygen-glucose deprivation
Regulation (effect) of Gene_expression (exposure) of lipopolysaccharide in neuronal associated with agonist and death
19) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.42 Pain Relevance 0.25
Although the levels of TLR-2 and TLR-4 expression did not increase in the human placenta during labor or in response to TNF-?
Regulation (levels) of Gene_expression (expression) of TLR-4 in placenta
20) Confidence 0.16 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.61 Pain Relevance 0.23

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