INT103781

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.42
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Smad4) nucleus (Smad4) intracellular (Smad4)
DNA binding (Smad4) protein complex (Smad4) cytoplasm (Smad4)
Anatomy Link Frequency
epithelial cells 2
pancreatic duct 2
Smad4 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 18 88.04 High High
Enkephalin 2 25.00 Low Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 147 100.00 Very High Very High Very High
Adenocarcinoma 122 96.88 Very High Very High Very High
Pancreatic Cancer 119 95.08 Very High Very High Very High
Disease 4 92.08 High High
Pancreatitis 22 88.04 High High
Microsatellite Instability 5 86.24 High High
Malignant Neoplastic Disease 10 82.80 Quite High
Carcinoma 6 77.32 Quite High
Colon Cancer 4 65.80 Quite High
Retinoblastoma 2 47.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most common genetic aberrations in pancreatic duct cell carcinogenesis involve the activation of KRAS oncogene and inactivation of tumor suppressor genes p16/CDKN2, p53 and SMAD4/DPC4 [3].
Negative_regulation (inactivation) of DPC4 in pancreatic duct associated with cancer
1) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.95 Pain Relevance 0
In addition, allelic losses of tumor suppressor genes p16 (INK4, CDKN2A) and DPC4 (MADH4, SMAD4) were detected by monitoring the loss of heterozygosity (LOH) at 9p and 18q, respectively.
Negative_regulation (losses) of DPC4
2) Confidence 0.37 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0
The most common genetic aberrations in pancreatic duct cell carcinogenesis involve the activation of KRAS oncogene and inactivation of tumor suppressor genes p16/CDKN2, p53 and SMAD4/DPC4 [3].
Negative_regulation (inactivation) of SMAD4 in pancreatic duct associated with cancer
3) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.95 Pain Relevance 0
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (loss) of Smad4 in epithelial cells
4) Confidence 0.28 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (loss) of DPC4 in epithelial cells
5) Confidence 0.28 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
CONCLUSION: EUS-guided FNA cytology combined with screening of K-ras mutations and allelic losses of tumor suppressors p16 and DPC4 represents a very sensitive approach in screening for pancreatic malignancy.
Negative_regulation (losses) of DPC4
6) Confidence 0.27 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0
In addition, allelic losses of tumor suppressor genes p16 (INK4, CDKN2A) and DPC4 (MADH4, SMAD4) were detected by monitoring the loss of heterozygosity (LOH) at 9p and 18q, respectively.
Negative_regulation (losses) of MADH4
7) Confidence 0.27 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0
In addition, allelic losses of tumor suppressor genes p16 (INK4, CDKN2A) and DPC4 (MADH4, SMAD4) were detected by monitoring the loss of heterozygosity (LOH) at 9p and 18q, respectively.
Negative_regulation (losses) of SMAD4
8) Confidence 0.27 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0
After whole genome amplification by improved primer extension and preamplification PCR (I-PEP-PCR), microsatellite-PCR based loss of heterozygosity analysis (LOH) of the tumor suppressor gene loci TP53, p16INK4, and DPC4 was performed.
Negative_regulation (loss) of DPC4 associated with cancer
9) Confidence 0.15 Published 2003 Journal Pathol. Res. Pract. Section Abstract Doc Link 12924436 Disease Relevance 0.58 Pain Relevance 0.31
BACKGROUND & AIMS: The functional abrogation of several tumor suppressor genes, including p16, DPC4, and p53, is a major mechanism underlying pancreatic ductal carcinogenesis.
Negative_regulation (abrogation) of DPC4 associated with cancer
10) Confidence 0.05 Published 2002 Journal Gastroenterology Section Abstract Doc Link 12105864 Disease Relevance 0.26 Pain Relevance 0

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