INT103782

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.57
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
reticulum 1
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 99.96 Very High Very High Very High
cytokine 44 96.92 Very High Very High Very High
Inflammation 77 89.92 High High
Multiple sclerosis 3 88.48 High High
interstitial cystitis 123 72.80 Quite High
chemokine 36 61.76 Quite High
headache 1 30.04 Quite Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 210 99.98 Very High Very High Very High
Depression 8 99.96 Very High Very High Very High
Malaria 45 98.64 Very High Very High Very High
Stress 29 93.64 High High
Infection 68 91.80 High High
Diabetes Mellitus 6 90.72 High High
INFLAMMATION 80 89.92 High High
Demyelinating Disease 3 88.48 High High
Immune System Diseases 3 84.40 Quite High
Interstitial Cystitis 123 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, caution should be paid to the possible drug interactions of E. rutaecarpa and CYP substrates.
CYP Binding (interactions) of
1) Confidence 0.12 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0 Pain Relevance 0
To explain, CYP is an "alkylating agent" that binds DNA and disrupts cell division.
CYP Binding (binds) of
2) Confidence 0.11 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.59 Pain Relevance 0.27
It is important to mention that acrolein, the highly reactive aldehyde derived from the metabolism of CYP, is responsible for the cystitis associated with CYP administration [13].
CYP Binding (associated) of associated with cystitis
3) Confidence 0.10 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.74 Pain Relevance 0.11
Mice with CYP-induced cystitis exhibited increased IFN-?
CYP Binding (Mice) of associated with cystitis
4) Confidence 0.09 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.46 Pain Relevance 0.16
Additionally, hypotheses on the association of CYP depression with enhanced nitric oxide (NO) production, and of CYP2a5 induction with endoplasmic reticulum dysfunction, enhanced haem metabolism and oxidative stress were examined as well.


CYP Binding (association) of in reticulum associated with stress and depression
5) Confidence 0.04 Published 2010 Journal Malar J Section Abstract Doc Link PMC2858213 Disease Relevance 0.79 Pain Relevance 0.05

General Comments

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