INT103791

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2009
Negated 0
Speculated 4
Reported most in Abstract
Documents 10
Total Number 16
Disease Relevance 11.24
Pain Relevance 7.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
visceral 4
neurons 4
dorsal root ganglion 4
sensory neurons 2
parotid gland 2
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 64 100.00 Very High Very High Very High
Inflammation 192 99.98 Very High Very High Very High
nociceptor 31 99.84 Very High Very High Very High
nud 170 99.80 Very High Very High Very High
Pain 24 99.56 Very High Very High Very High
qutenza 19 99.16 Very High Very High Very High
opioid receptor 8 98.96 Very High Very High Very High
substance P 4 98.76 Very High Very High Very High
Calcitonin gene-related peptide 5 98.48 Very High Very High Very High
trigeminal ganglion 6 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

97 100.00 Very High Very High Very High
INFLAMMATION 198 99.98 Very High Very High Very High
Dyspepsia 170 99.80 Very High Very High Very High
Nociception 69 99.80 Very High Very High Very High
Neurogenic Inflammation 2 99.64 Very High Very High Very High
Pain 32 99.56 Very High Very High Very High
Diarrhoea 1 98.46 Very High Very High Very High
Ganglion Cysts 140 97.48 Very High Very High Very High
Hypersensitivity 47 94.00 High High
Facial Pain 1 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify involvement of protease-activated receptor-2 (PAR-2) in parotid pain, we examined whether PAR-2 activation in the parotid gland could activate trigeminal nociceptive neurons in anesthetized rats, by analyzing immunoreactive Fos as a nociceptive marker.
Positive_regulation (activate) of Positive_regulation (activation) of PAR-2 in parotid gland associated with nociception and pain
1) Confidence 0.50 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232294 Disease Relevance 0.42 Pain Relevance 0.30
In this study we investigated the nociceptive pathways induced by activation of protease-activated receptor 2 (PAR-2) in damage-sensing (nociceptive) neurons from rat dorsal root ganglion (DRG).
Spec (investigated) Positive_regulation (induced) of Spec (investigated) Positive_regulation (activation) of protease-activated receptor 2 in dorsal root ganglion associated with ganglion cysts, nociception and dorsal root ganglion
2) Confidence 0.50 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971466 Disease Relevance 1.02 Pain Relevance 0.46
In this study we investigated the nociceptive pathways induced by activation of protease-activated receptor 2 (PAR-2) in damage-sensing (nociceptive) neurons from rat dorsal root ganglion (DRG).
Spec (investigated) Positive_regulation (induced) of Spec (investigated) Positive_regulation (activation) of PAR-2 in dorsal root ganglion associated with ganglion cysts, nociception and dorsal root ganglion
3) Confidence 0.50 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971466 Disease Relevance 1.07 Pain Relevance 0.47
Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats.
Positive_regulation (protease-activated) of Positive_regulation (activation) of protease-activated receptor-2
4) Confidence 0.50 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 12106807 Disease Relevance 0 Pain Relevance 0.07
Activation of protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, induces neurally mediated gastric mucus secretion accompanied by mucosal cytoprotection.
Positive_regulation (induces) of Positive_regulation (Activation) of protease-activated receptor-2
5) Confidence 0.50 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106807 Disease Relevance 0 Pain Relevance 0
Activation of protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, induces neurally mediated gastric mucus secretion accompanied by mucosal cytoprotection.
Positive_regulation (induces) of Positive_regulation (Activation) of PAR-2
6) Confidence 0.50 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106807 Disease Relevance 0 Pain Relevance 0
Protease activation of the proteinase-activated receptor-2 also increases visceral nociception in rats, suggesting that an increase in paracellular permeability may be the primum movens in several animal models of visceral hypersensitivity.
Positive_regulation (increases) of Positive_regulation (activation) of proteinase-activated receptor-2 in visceral associated with nociception and nud
7) Confidence 0.46 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17280583 Disease Relevance 0.89 Pain Relevance 0.29
Protease activation of the proteinase-activated receptor-2 also increases visceral nociception in rats, suggesting that an increase in paracellular permeability may be the primum movens in several animal models of visceral hypersensitivity.
Positive_regulation (activation) of Positive_regulation (proteinase-activated) of proteinase-activated receptor-2 in visceral associated with nociception and nud
8) Confidence 0.46 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17280583 Disease Relevance 0.89 Pain Relevance 0.29
Moreover, activation of PAR-2 can also induce functional competence in DOR.
Positive_regulation (induce) of Positive_regulation (activation) of PAR-2 associated with opioid receptor
9) Confidence 0.44 Published 2006 Journal Pain Section Abstract Doc Link 16781076 Disease Relevance 0.28 Pain Relevance 1.11
Since we know that activation of the PAR2 receptor causes the release of SP, the data suggests that activation of PAR2 receptors on CANs may mediate the visceral hypersensitivity response via the release of SP acting on the remaining NK1 receptors expressed on DRG neurons.
Positive_regulation (causes) of Positive_regulation (activation) of PAR2 in neurons associated with dorsal root ganglion and nud
10) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 1.38 Pain Relevance 0.75
Since we know that activation of the PAR2 receptor causes the release of SP, the data suggests that activation of PAR2 receptors on CANs may mediate the visceral hypersensitivity response via the release of SP acting on the remaining NK1 receptors expressed on DRG neurons.
Spec (may) Positive_regulation (mediate) of Positive_regulation (activation) of PAR2 in neurons associated with dorsal root ganglion and nud
11) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 1.32 Pain Relevance 0.73
Our data show that inflammation causes an up-regulation of the NMDA receptor and the activation of the PAR2 receptor expressed on CANs.
Positive_regulation (causes) of Positive_regulation (activation) of PAR2 associated with inflammation and nmda receptor
12) Confidence 0.39 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2758842 Disease Relevance 0.90 Pain Relevance 0.58
Also, TNBS inflammation causes the activation of the PAR2 receptors and this activation may cause the release of SP.
Positive_regulation (causes) of Positive_regulation (activation) of PAR2 associated with inflammation
13) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 1.29 Pain Relevance 0.97
In the present study, the role of capsaicin-sensitive sensory neurons in contraction induced by activation of PAR-2 was investigated in the rat urinary bladders.
Positive_regulation (induced) of Positive_regulation (activation) of PAR-2 in sensory neurons associated with qutenza
14) Confidence 0.32 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17588562 Disease Relevance 0 Pain Relevance 0.50
A recent study has evidenced that stool supernatants from diarrhea predominant IBS patients have a high level of serine-protease activity that increases permeability and colonic hypersensitivity when infused intra-colonically in mice, and these effects are linked to activation of PAR-2 receptors.
Positive_regulation (increases) of Positive_regulation (activation) of PAR-2 associated with diarrhoea
15) Confidence 0.31 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924448 Disease Relevance 0.34 Pain Relevance 0.09
In conclusion, intradermal trypsin elicits a neurogenic inflammation in rat, probably mediated via PAR-2 activation on nociceptors and subsequent SP and CGRP release.
Spec (probably) Positive_regulation (mediated) of Positive_regulation (activation) of PAR-2 in nociceptors associated with inflammation, nociceptor, neurogenic inflammation, calcitonin gene-related peptide and substance p
16) Confidence 0.24 Published 2006 Journal Exp. Dermatol. Section Abstract Doc Link 16364032 Disease Relevance 0.66 Pain Relevance 0.79

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