INT103796

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, SELE) cytosol (IL1B) signal transduction (IL1B)
aging (IL1B) extracellular region (IL1B) cell adhesion (SELE)
Anatomy Link Frequency
endothelial cells 2
IL1B (Homo sapiens)
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 4 99.38 Very High Very High Very High
cytokine 17 98.04 Very High Very High Very High
Inflammation 32 86.48 High High
rheumatoid arthritis 121 84.56 Quite High
antagonist 1 76.28 Quite High
chemokine 30 75.00 Quite High
Infliximab 5 74.00 Quite High
Clonidine 1 73.64 Quite High
Etanercept 1 70.48 Quite High
Pain 2 61.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.20 Very High Very High Very High
Rheumatoid Arthritis 121 84.56 Quite High
Pain 2 61.20 Quite High
Injury 1 55.40 Quite High
Apoptosis 5 50.00 Quite Low
Arthritis 10 46.84 Quite Low
Disease 13 44.12 Quite Low
Adhesions 28 32.08 Quite Low
Osteoarthritis 18 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NHE inhibition decreased also the IL-1beta-induced HUVEC inflammatory response, because amiloride suppressed IL-1beta-induced E-selectin expression on HUVECs.
IL-1beta-induced Positive_regulation (induced) of Gene_expression (expression) of E-selectin associated with inflammatory response
1) Confidence 0.08 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.43 Pain Relevance 0.35
In addition, IL-1 and TNF upregulate the expression of ICAM-1, VCAM-1 and E-selectin on endothelial cells, stimulating leukocyte migration into the joint [76,104].
IL-1 Positive_regulation (upregulate) of Gene_expression (expression) of E-selectin in endothelial cells
2) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.57 Pain Relevance 0.63

General Comments

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