INT1038

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 26
Total Number 28
Disease Relevance 15.12
Pain Relevance 6.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
liver 4
platelet 3
plasma 2
thoracic 2
thorax 1
F2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Paracetamol 34 99.48 Very High Very High Very High
anesthesia 11 99.40 Very High Very High Very High
alcohol 15 97.72 Very High Very High Very High
Angina 5 97.68 Very High Very High Very High
addiction 1 97.28 Very High Very High Very High
cINOD 6 95.76 Very High Very High Very High
epidural 13 95.40 Very High Very High Very High
withdrawal 2 94.76 High High
tolerance 1 93.44 High High
Disease Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Jaundice 2 99.96 Very High Very High Very High
Hepatotoxicity 14 99.92 Very High Very High Very High
Coagulation Disorder 3 99.74 Very High Very High Very High
Renal Disease 1 99.72 Very High Very High Very High
Encephalopathy 1 99.70 Very High Very High Very High
Stress 4 99.60 Very High Very High Very High
Pressure Volume 2 Under Development 33 99.28 Very High Very High Very High
Arterial-venous Cerebral Malformations 6 99.24 Very High Very High Very High
Injury 10 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eleutherin has a weak and transient effect of decreasing the prothrombin time (in vivo in rats) and a weak antibacterial activity on Bacillus subtilis (in vitro).
Negative_regulation (decreasing) of prothrombin associated with bacterial respiratory disease
1) Confidence 0.58 Published 1975 Journal J Pharm Sci Section Abstract Doc Link 807711 Disease Relevance 0.19 Pain Relevance 0
At the dose levels used by the authors, mithramycin induces only certain metabolic anomalies (rise in transaminases, decrease in the prothrombin level...) which return to normal at the end of treatment.
Negative_regulation (decrease) of prothrombin
2) Confidence 0.57 Published 1975 Journal Rev Rhum Mal Osteoartic Section Abstract Doc Link 131365 Disease Relevance 0.63 Pain Relevance 0.33
A prothrombin time decrease to less than 50% (INR > 1.75) is the first sign of acute severe liver failure.
Negative_regulation (decrease) of prothrombin in liver
3) Confidence 0.57 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 12859298 Disease Relevance 0.08 Pain Relevance 0
Acute neurological decline after spontaneous thrombosis of an intracranial AVM is rare, and an association with the prothrombin defect in this patient is likely.
Negative_regulation (defect) of prothrombin associated with arterial-venous cerebral malformations and thrombosis
4) Confidence 0.57 Published 2007 Journal J. Neurosurg. Section Abstract Doc Link 17330543 Disease Relevance 1.26 Pain Relevance 0.19
The parameters associated to a higher mortality were: age, absence of thoracic pain, reduction in the level of consciousness, leukocytosis, increased urea levels, aminotransferases, lactate dehydrogenase and reduction in prothrombin activity and pH.
Negative_regulation (reduction) of prothrombin in thoracic associated with pain and leukocytosis
5) Confidence 0.48 Published 1995 Journal An Med Interna Section Abstract Doc Link 7795115 Disease Relevance 0.60 Pain Relevance 0.19
The microsomal function, measured as the prothrombin time, was reversibly decreased to a minimum 12 h after paracetamol administration and showed dose dependence.
Negative_regulation (decreased) of prothrombin associated with addiction and paracetamol
6) Confidence 0.43 Published 1981 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 6791935 Disease Relevance 0.16 Pain Relevance 0.63
Prothrombin index was reduced to a minimum after 12 hours and reestablished after 24 hours.
Negative_regulation (reduced) of Prothrombin
7) Confidence 0.43 Published 1984 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 6711319 Disease Relevance 0.39 Pain Relevance 0.15
Prothrombin index was reduced to a minimum after 12 hours and reestablished after 24 hours.
Negative_regulation (reestablished) of Prothrombin
8) Confidence 0.43 Published 1984 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 6711319 Disease Relevance 0.40 Pain Relevance 0.16
At the 24-hr pretreatment time, only phenylbutazone significantly reduced the elevated prothrombin time.
Negative_regulation (reduced) of prothrombin
9) Confidence 0.43 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.46
Also prothrombin index was reduced more and earlier from the combination.
Negative_regulation (reduced) of prothrombin
10) Confidence 0.36 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3977950 Disease Relevance 0.07 Pain Relevance 0.73
The data associated to a greater relative risk were: age above 80 years, absence of thoracic pain, prothrombin activity lower than 70% and ALT < 40 U/l.
Negative_regulation (absence) of prothrombin in thoracic associated with pain
11) Confidence 0.35 Published 1995 Journal An Med Interna Section Abstract Doc Link 7795115 Disease Relevance 0.59 Pain Relevance 0.19
In the multivariable analysis, the following variables remained significative: age, obnubilation and decrease of prothrombin.
Negative_regulation (decrease) of prothrombin
12) Confidence 0.35 Published 1995 Journal An Med Interna Section Abstract Doc Link 7795115 Disease Relevance 0.55 Pain Relevance 0.17
The parameters associated with greater mortality were: age, absence of thoracic pain, obnubilation, hypotension, elevation in urea, GOT, GPT, LDH, decrease in prothrombin activity, pO2, pH, albumin, and the affectation of more than one lobe in a radiography of the thorax.
Negative_regulation (decrease) of prothrombin in thorax associated with pain and pressure volume 2 under development
13) Confidence 0.17 Published 1994 Journal Rev Clin Esp Section Abstract Doc Link 8022991 Disease Relevance 0.53 Pain Relevance 0.10
In the multivariant analysis remained as significant: age, obnubilation, elevation in LDH, and decrease in the activity of prothrombin and pH.
Negative_regulation (decrease) of prothrombin
14) Confidence 0.17 Published 1994 Journal Rev Clin Esp Section Abstract Doc Link 8022991 Disease Relevance 0.43 Pain Relevance 0.08
Previous studies have described transient postoperative rises in serum aminotransferase levels and decreases in prothrombin time and factor V levels.
Negative_regulation (decreases) of prothrombin
15) Confidence 0.14 Published 2006 Journal Pharmacology Section Abstract Doc Link 16837779 Disease Relevance 0.10 Pain Relevance 0.35
Routine preoperative blood analysis revealed an isolated deficiency in factor VII (33%), with a normal activated partial thromboplastin time and a reduced prothrombin level (50%).
Spec (partial) Negative_regulation (reduced) of prothrombin in blood
16) Confidence 0.09 Published 1990 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 2184705 Disease Relevance 0.36 Pain Relevance 0.07
She took 3.25 g of acetaminophen for abdominal cramping and subsequently had rapid deterioration of liver function manifested by prolongation of the prothrombin time, elevated ammonia, marked elevation of transaminases, and hyperbilirubinemia.
Negative_regulation (prolongation) of prothrombin in liver associated with hyperbilirubinemia and paracetamol
17) Confidence 0.07 Published 1993 Journal Am. J. Gastroenterol. Section Abstract Doc Link 8470644 Disease Relevance 0.51 Pain Relevance 0.44
Inhibition of factor VIIa generation and prothrombin activation by treatment with enoxaparin in patients with unstable angina.
Negative_regulation (Inhibition) of prothrombin associated with angina
18) Confidence 0.06 Published 2003 Journal Br. J. Haematol. Section Title Doc Link 12588347 Disease Relevance 0.19 Pain Relevance 0.19
Decreases in prothrombin time, partial thromboplastin time, and international normalized ratio were observed.
Negative_regulation (Decreases) of prothrombin
19) Confidence 0.06 Published 2007 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 17636185 Disease Relevance 0.56 Pain Relevance 0.10
As the number of functioning hepatocytes decrease, the prothrombin time elevates.
Negative_regulation (decrease) of prothrombin in hepatocytes
20) Confidence 0.05 Published 2010 Journal Journal of the American Academy of Nurse Practitioners Section Body Doc Link PMC3017746 Disease Relevance 1.30 Pain Relevance 0.03

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