INT103800

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Context Info
Confidence 0.33
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.50
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SLC9A1) plasma membrane (SLC9A1) transcription factor binding (SLC9A1)
transmembrane transport (SLC9A1)
Anatomy Link Frequency
Caco-2 1
myocardial cell 1
SLC9A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 4 99.98 Very High Very High Very High
ischemia 56 99.74 Very High Very High Very High
cva 22 88.00 High High
Angina 14 86.64 High High
chemokine 2 75.00 Quite High
Clonidine 1 68.24 Quite High
Inflammation 2 59.52 Quite High
depression 4 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.80 Very High Very High Very High
Cv Unclassified Under Development 54 99.74 Very High Very High Very High
Death 24 98.48 Very High Very High Very High
Myocardial Infarction 92 88.96 High High
Cv General 3 Under Development 22 88.00 High High
Angina 14 86.64 High High
Arrhythmias 2 Under Development 2 84.72 Quite High
Reperfusion Injury 2 81.20 Quite High
Necrosis 30 73.64 Quite High
Left Ventricular Dysfunction 10 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NHE-1 is ubiquitously distributed in tissue, and is the predominant NHE isoform in the myocardial cell.
Positive_regulation (distributed) of NHE-1 in myocardial cell
1) Confidence 0.33 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.69 Pain Relevance 0.12
The assumption was made that once ischemia is present, the mechanisms that lead to cell death are similar independently of the immediate trigger to ischemia, with major participation of the NHE.
Positive_regulation (participation) of NHE associated with ischemia and death
2) Confidence 0.31 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 1.36 Pain Relevance 0.36
These results demonstrate that maximal activation of the HUVEC inflammatory response requires a functional NHE.
Positive_regulation (requires) of NHE associated with inflammatory response
3) Confidence 0.20 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.45 Pain Relevance 0.33
Previous work demonstrated that NHE3 (but not NHE1 or NHE2) is selectively activated by the intracellular acidification associated with H+/dipeptide symport in Caco-2 cell monolayers [10,12].
Positive_regulation (activated) of NHE1 in Caco-2
4) Confidence 0.17 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2428106 Disease Relevance 0 Pain Relevance 0

General Comments

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