INT103803

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (CAPG) nucleus (CAPG) protein complex assembly (CAPG)
cytoplasm (CAPG)
Anatomy Link Frequency
astrocytes 2
vein 2
CAPG (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 1 99.26 Very High Very High Very High
Inflammation 3 89.80 High High
Inflammatory response 4 84.96 Quite High
chemokine 2 75.00 Quite High
metalloproteinase 1 73.76 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 91 99.56 Very High Very High Very High
INFLAMMATION 6 89.80 High High
Injury 3 80.28 Quite High
Scotoma 2 71.28 Quite High
Ganglion Cysts 23 68.52 Quite High
Hypertension 3 58.64 Quite High
Stress 1 39.52 Quite Low
Cancer 1 30.88 Quite Low
Ocular Hypertension 18 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, increased expression of capping protein G (CAPG) was shown previously by microarray and Western blot in purified human optic nerve head astrocytes from glaucomatous donors [11].
Positive_regulation (increased) of Gene_expression (expression) of CAPG in astrocytes
1) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.97 Pain Relevance 0.04
NHE inhibition using amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, and 5-(N-methyl-N-isobutyl)amiloride as well as the non-amiloride NHE inhibitors cimetidine, clonidine, and harmaline suppressed endotoxin-induced IL-8 and monocyte chemoattractant protein (MCP)-1 production by human umbilical endothelial vein cells (HUVECs).
Positive_regulation (induced) of Gene_expression (production) of MCP in vein associated with clonidine
2) Confidence 0.19 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.46 Pain Relevance 0.33

General Comments

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