INT103823

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.69
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
MIA PaCa-2 6
cleavage 2
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 160 96.56 Very High Very High Very High
lidocaine 1 93.60 High High
Osteoarthritis 27 89.24 High High
Inflammation 10 84.16 Quite High
metalloproteinase 2 81.36 Quite High
cytokine 10 68.32 Quite High
Chronic pancreatitis 4 61.92 Quite High
cINOD 54 59.96 Quite High
Codeine 6 50.00 Quite Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 44 99.84 Very High Very High Very High
Apoptosis 91 99.40 Very High Very High Very High
Pancreatic Cancer 20 98.28 Very High Very High Very High
Lung Injury 3 98.00 Very High Very High Very High
Necrosis 5 95.84 Very High Very High Very High
Cancer 28 95.48 Very High Very High Very High
Disease 7 94.32 High High
Stress 17 91.00 High High
Parkinson's Disease 8 89.76 High High
Osteoarthritis 27 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antiapoptotic role of SOD2 is even demonstrated by the resistance to the radiation-induced damage reported for cell lines overexpressing SOD2 [47].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SOD2
1) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.64 Pain Relevance 0.22
[52]; furthermore, thiol-reducing agents can affect SOD2 biosynthesis, as demonstrated by the enhanced SOD2 expression caused by thioredoxin, a potent disulfide oxidoreductase [31].
Positive_regulation (enhanced) of Gene_expression (expression) of SOD2
2) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.35 Pain Relevance 0.10
Overexpression of MnSOD may be effective in growth suppression of pancreatic cancer.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of MnSOD associated with pancreatic cancer
3) Confidence 0.67 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.56 Pain Relevance 0
MnSOD was overexpressed in MIA PaCa-2 using an adenoviral vector, and the effect on cell growth was determined.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MnSOD in MIA PaCa-2
4) Confidence 0.67 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.71 Pain Relevance 0.06
This protection was accompanied by increased pulmonary MnSOD, VEGF expression and decreased apoptosis.
Positive_regulation (increased) of Gene_expression (expression) of MnSOD associated with apoptosis
5) Confidence 0.49 Published 2002 Journal Front. Biosci. Section Abstract Doc Link 12108429 Disease Relevance 0.69 Pain Relevance 0.17
Enforced expression of MnSOD by adenovirus transfection in the rapid growing cell line MIA PaCa-2 increased MnSOD immunoreactivity and MnSOD activity and decreased growth rate.
Positive_regulation (Enforced) of Gene_expression (expression) of MnSOD in MIA PaCa-2
6) Confidence 0.49 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.51 Pain Relevance 0
Enforced expression of MnSOD by adenovirus transfection in the rapid growing cell line MIA PaCa-2 increased MnSOD immunoreactivity and MnSOD activity and decreased growth rate.
Positive_regulation (increased) of Gene_expression (expression) of MnSOD in MIA PaCa-2
7) Confidence 0.49 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.50 Pain Relevance 0
Codeinone stimulated the release of both cytochrome c and cytochrome oxidase, and cleavage of procaspase 3 without significant changes in both the activity and expression of MnSOD.
Positive_regulation (stimulated) of Gene_expression (expression) of MnSOD in cleavage
8) Confidence 0.47 Published 2003 Journal Anesthesiology Section Body Doc Link 12606908 Disease Relevance 0.05 Pain Relevance 0
MnSOD overexpression in breast cancer cell lines leads to upregulation of GAD153 (which is involved in the repair of double strand breaks in DNA) and to a variety of redox-sensitive transcription factors [7].
Positive_regulation (overexpression) of Gene_expression (overexpression) of MnSOD associated with breast cancer
9) Confidence 0.47 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.46 Pain Relevance 0.16
The results showed a significant (P < 0.001) up-regulation of SOD2 gene expression in IL-1?
Positive_regulation (up-regulation) of Gene_expression (expression) of SOD2 gene
10) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.23 Pain Relevance 0.07

General Comments

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