INT103828

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 23
Total Number 25
Disease Relevance 13.63
Pain Relevance 13.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
nerves 6
neurons 4
sensory neurons 2
spinal cord 2
epithelium 2
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 234 100.00 Very High Very High Very High
antagonist 22 100.00 Very High Very High Very High
nociceptor 19 100.00 Very High Very High Very High
Thermal hyperalgesia 19 100.00 Very High Very High Very High
Calcitonin gene-related peptide 13 100.00 Very High Very High Very High
dorsal root ganglion 87 99.96 Very High Very High Very High
Pain score 13 99.72 Very High Very High Very High
Spinal cord 47 99.46 Very High Very High Very High
Pain 122 99.40 Very High Very High Very High
Eae 34 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 40 100.00 Very High Very High Very High
Ganglion Cysts 107 99.96 Very High Very High Very High
Neuropathic Pain 66 99.84 Very High Very High Very High
Pain 115 99.60 Very High Very High Very High
Frailty 3 99.60 Very High Very High Very High
Glioma 7 99.56 Very High Very High Very High
Hypersensitivity 16 99.38 Very High Very High Very High
Glioblastoma 2 98.84 Very High Very High Very High
Targeted Disruption 30 98.72 Very High Very High Very High
Injury 75 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of VR1 is plastic and down-regulated during vanilloid therapy, which might have a pivotal role in desensitization.
Negative_regulation (down-regulated) of Gene_expression (expression) of VR1
1) Confidence 0.59 Published 2002 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12109845 Disease Relevance 0.47 Pain Relevance 0.48
The association of increased keratinocyte TRPV1 in human conditions with pain has recently been demonstrated in women with breast pain, in patients with rectal hypersensitivity and faecal urgency, as well as in pruritic skin of patients with prurigo nodularis.8,23,24 We recently described a patient with steroid-responsive small nerve fibre symptoms of burning feet and hands, where keratinocytes showed strong TRPV1 expression.25 On follow-up skin biopsy after steroid administration, keratinocyte TRPV1 expression was drastically reduced in parallel with remission of clinical symptoms (manuscript in preparation).
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 in keratinocytes associated with pain and pruritus
2) Confidence 0.59 Published 2007 Journal Histopathology Section Body Doc Link PMC2121152 Disease Relevance 0.74 Pain Relevance 0.53
Under the noted threshold values, however, these vanilloids were harmless to cells lacking TRPV1 expression.
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of TRPV1
3) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.14 Pain Relevance 0.19
We found that TRPV1 gene and protein expression inversely correlated with glioma grading, with marked loss of TRPV1 expression in the majority of grade IV glioblastoma multiforme.
Negative_regulation (loss) of Gene_expression (expression) of TRPV1 associated with glioblastoma and glioma
4) Confidence 0.59 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17442041 Disease Relevance 0.95 Pain Relevance 0.44
These results suggest that the decreased expression of TRPV1 may be related to a functional knock out in capsaicin sensation and hypersensitivity to allicin in humans.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV1 associated with targeted disruption, qutenza and hypersensitivity
5) Confidence 0.58 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17110039 Disease Relevance 0.37 Pain Relevance 0.33
Induction of total insensitivity to capsaicin and hypersensitivity to garlic extract in human by decreased expression of TRPV1.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV1 associated with qutenza and hypersensitivity
6) Confidence 0.58 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17110039 Disease Relevance 0.18 Pain Relevance 0.46
Likewise RTX application is followed by a reduction in urothelial TRPV1 expression [3].
Negative_regulation (reduction) of Gene_expression (expression) of TRPV1
7) Confidence 0.57 Published 2007 Journal BMC Urol Section Body Doc Link PMC1903357 Disease Relevance 0.12 Pain Relevance 0.46
Chemoradiotherapy may reduce the expression of TRPV1, 2, 3, and 4, which might be a result of the mucositis and neuropathy in laryngeal epithelium.


Spec (may) Negative_regulation (reduce) of Gene_expression (expression) of TRPV1 in epithelium
8) Confidence 0.51 Published 2009 Journal Acta Otolaryngol. Section Body Doc Link 18629672 Disease Relevance 0 Pain Relevance 0
Attenuation of thermal hyperalgesia mediated by NT-3 correlates with decreased TRPV1 expression such that only approximately 26% of neurons ipsilateral to CCI expressed detectable TRPV1 mRNA.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV1 in neurons associated with eae and thermal hyperalgesia
9) Confidence 0.51 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15659614 Disease Relevance 1.47 Pain Relevance 1.19
Continuous infusion is required for suppression of both thermal hyperalgesia and TRPV1 expression, because removal of NT-3 resulted in a prompt reestablishment of the hyperalgesic state and corresponding CCI-associated TRPV1 phenotype.
Negative_regulation (suppression) of Gene_expression (expression) of TRPV1 associated with hyperalgesia, eae and thermal hyperalgesia
10) Confidence 0.51 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15659614 Disease Relevance 1.52 Pain Relevance 1.28
The salivary flow of the transplanted glands was significantly decreased, and the mRNA and protein levels of TRPV1 and aquaporin 5 (AQP5) were downregulated in the transplanted glands.
Negative_regulation (downregulated) of Gene_expression (levels) of TRPV1 in glands
11) Confidence 0.49 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20360133 Disease Relevance 0.08 Pain Relevance 0.55
Evidence is mounting that VR1 expression is not restricted to sensory neurons.
Neg (not) Negative_regulation (restricted) of Gene_expression (expression) of VR1 in sensory neurons
12) Confidence 0.43 Published 2002 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12109845 Disease Relevance 0.47 Pain Relevance 0.54
Factors that downregulate TRPV1 expression include vanilloid treatment and growth factor (notably, nerve growth factor) deprivation.
Negative_regulation (downregulate) of Gene_expression (expression) of TRPV1 in nerve associated with nerve growth factor
13) Confidence 0.43 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15128291 Disease Relevance 0.55 Pain Relevance 0.38
In our study we found positive staining of TRPV1?
Negative_regulation (positive) of Gene_expression (staining) of TRPV1
14) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.19 Pain Relevance 0.83
There was a clear decrease in the expression of TRPV1 in neuropathic nerves compared to controls.
Spec (clear) Negative_regulation (decrease) of Gene_expression (expression) of TRPV1 in nerves associated with neuropathic pain
15) Confidence 0.42 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 1.24 Pain Relevance 0.73
However, there is increasing evidence that TRPV1 expression is not limited to primary afferent neurons but that the receptor is expressed in various cell types throughout the body.
Neg (not) Negative_regulation (limited) of Gene_expression (expression) of TRPV1 in body
16) Confidence 0.42 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17560936 Disease Relevance 0.77 Pain Relevance 0.43
This increase was blocked by the TRPV1 antagonist, SB-366791 (30 ?
Negative_regulation (blocked) of Gene_expression (antagonist) of TRPV1 associated with antagonist
17) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.13 Pain Relevance 0.15
In painful neuropathies, intraepidermal TRPV1 nerve fibre expression is low or absent, suggesting that pain generated is not directly related to sensory nerve fibres.
Negative_regulation (absent) of Neg (absent) Gene_expression (expression) of TRPV1 in sensory nerve associated with pain
18) Confidence 0.38 Published 2007 Journal Histopathology Section Abstract Doc Link PMC2121152 Disease Relevance 0.65 Pain Relevance 0.45
Yet, the same finding was seen following spinal cord injury in rat [61], where TRPV-1 receptor gene expression levels were decreased at the level of spinal cord injury but increased at rostral spinal cord areas.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV-1 receptor gene in spinal cord associated with spinal cord
19) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.60 Pain Relevance 0.57
When the two groups were combined together, the average pain score (VASav) also correlated with TRPV1 levels (p<0.001, r?
Negative_regulation (correlated) of Gene_expression (levels) of TRPV1 associated with pain score
20) Confidence 0.36 Published 2008 Journal Gut Section Body Doc Link PMC2564830 Disease Relevance 0.64 Pain Relevance 1.31

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