INT10384

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 62
Total Number 62
Disease Relevance 14.27
Pain Relevance 11.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1)
cytoplasm (Nqo1)
Anatomy Link Frequency
liver 7
neurons 5
bladder 4
small intestine 2
kidney 2
Nqo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 68 100.00 Very High Very High Very High
Pain 28 100.00 Very High Very High Very High
qutenza 73 99.98 Very High Very High Very High
Inflammation 104 99.56 Very High Very High Very High
agonist 5 99.52 Very High Very High Very High
Central grey 7 99.32 Very High Very High Very High
nociceptor 1 98.94 Very High Very High Very High
trigeminal ganglion 2 98.82 Very High Very High Very High
Spinal cord 25 98.76 Very High Very High Very High
Root ganglion neuron 4 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 17 99.84 Very High Very High Very High
INFLAMMATION 95 99.56 Very High Very High Very High
Prostate Cancer 588 99.36 Very High Very High Very High
Urological Neuroanatomy 11 99.32 Very High Very High Very High
Disease 44 99.12 Very High Very High Very High
Aids-related Complex 5 98.92 Very High Very High Very High
Ganglion Cysts 11 98.82 Very High Very High Very High
Heart Rate Under Development 9 98.24 Very High Very High Very High
Cancer 108 97.96 Very High Very High Very High
Nociception 8 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unilateral hindpaw inflammation did not result in an increase in NADPH-diaphorase activity in the periaqueductal gray or the ventroposteriolateral thalamic nucleus.
Positive_regulation (increase) of NADPH-diaphorase in nucleus associated with inflammation and central grey
1) Confidence 0.70 Published 1994 Journal Brain Res. Section Abstract Doc Link 8069693 Disease Relevance 0.35 Pain Relevance 0.26
At this time a bilateral increase of NADPH-diaphorase staining was observed in all areas and neuronal types of the dorsal horn, and in positive motoneurons in the lumbar spinal cord, ipsilateral to the lesion.
Positive_regulation (increase) of NADPH-diaphorase in dorsal horn associated with dorsal horn and spinal cord
2) Confidence 0.66 Published 1999 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 10347815 Disease Relevance 0 Pain Relevance 0.25
Axotomy increases NADPH-diaphorase activity in the dorsal root ganglia and lumbar spinal cord of the turtle Trachemys dorbigni.
Positive_regulation (increases) of NADPH-diaphorase in dorsal root ganglia associated with spinal cord
3) Confidence 0.66 Published 1999 Journal Braz. J. Med. Biol. Res. Section Title Doc Link 10347815 Disease Relevance 0 Pain Relevance 0.25
The degree of increase of NQO1, total GST and GST-mu enzymatic activities in the prostate tissues we observed was modest, and lower than that reported in other model systems where phase 2 enzyme inducing compounds have been documented to prevent carcinogenesis [25].
Positive_regulation (increase) of NQO1
4) Confidence 0.66 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.66 Pain Relevance 0
A number of compounds effective at inducing phase 2 enzyme activity have been identified by screening for nicotinomide quinone oxidoreductase (NQO1) enzymatic induction in the Hepa 1c1c7 cell line [10-12].
Positive_regulation (induction) of NQO1
5) Confidence 0.66 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.22 Pain Relevance 0.03
One notable finding was the significant induction of total GST and NQO1 enzymatic activities in bladder tissues of the F344 rats.
Positive_regulation (induction) of NQO1 in bladder
6) Confidence 0.66 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.86 Pain Relevance 0
Dimethyl fumarate, on the other hand, induces NQO1 enzymatic activity in the forestomach, small intestine, kidneys and lungs, but produces little change in NQO1 activity in the liver [11].
Positive_regulation (induces) of NQO1 in liver
7) Confidence 0.66 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.21 Pain Relevance 0
We have previously identified compounds effective at producing modest increases in NQO1 enzymatic activity in human prostate cells in vitro [18,19] and selected 4 compounds for testing whether they could produce induction of phase 2 enzyme activity in vivo.
Positive_regulation (increases) of NQO1
8) Confidence 0.66 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.06 Pain Relevance 0
Furthermore, modest induction of phase 2 enzymes (NQO1 and total GST), virtually identical to those reported in the present study, have been observed in the liver tissues of F344 rats treated with sulforaphane and sulforaphane nitrile derived from cruciferous vegetables [26].
Positive_regulation (induction) of NQO1 in liver
9) Confidence 0.66 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.65 Pain Relevance 0
NQO1 enzymatic activity was also higher in the kidney tissues of the sulforaphane, ?
Positive_regulation (higher) of NQO1 in kidney
10) Confidence 0.66 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0 Pain Relevance 0
The quinone-forming family, including NCX 4040 and conisogenic bromides and mesylate, was rapidly bioactivated to a quinone, which gave activation of ARE and consequent induction of NQO1 in liver cells.
Positive_regulation (induction) of NQO1 in liver
11) Confidence 0.62 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17975886 Disease Relevance 0.22 Pain Relevance 0.17
Although the control family, including NCX 4016 and conisogenic bromides and mesylates, cannot form a quinone, ARE activation and NQO1 induction were observed, compatible with slower SN2 reactions with thiol sensor proteins, and consequent ARE-luciferase and NQO1 induction.
Positive_regulation (induction) of NQO1
12) Confidence 0.62 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17975886 Disease Relevance 0.22 Pain Relevance 0.16
Although the control family, including NCX 4016 and conisogenic bromides and mesylates, cannot form a quinone, ARE activation and NQO1 induction were observed, compatible with slower SN2 reactions with thiol sensor proteins, and consequent ARE-luciferase and NQO1 induction.
Positive_regulation (induction) of NQO1
13) Confidence 0.62 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17975886 Disease Relevance 0.22 Pain Relevance 0.14
The relationship of NADPH-diaphorase to nitric oxide is discussed and it is concluded that NADPH-diaphorase,(ABSTRACT TRUNCATED AT 400 WORDS)
Positive_regulation (relationship) of NADPH-diaphorase
14) Confidence 0.50 Published 1994 Journal Brain Res. Section Abstract Doc Link 8069693 Disease Relevance 0.34 Pain Relevance 0.25
For instance, both tert-butyl-4-hydroxyanisole (BHA) and dimethyl fumarate are effective at inducing NQO1 activity in Hepa 1c1c7 cells in vitro, but in CD-1 mice, only BHA induces NQO1 activity in the liver (6-fold), in addition to the lung and kidney (2-fold), but not in the stomach and colon [17].
Positive_regulation (inducing) of NQO1 in lung
15) Confidence 0.47 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.20 Pain Relevance 0
NQO1 enzyme activities in bladder tissues were also significantly increased over controls in the animals treated with ?
Positive_regulation (increased) of NQO1 in bladder
16) Confidence 0.47 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0 Pain Relevance 0
-naphthoflavone, a bifunctional (phase 1 and 2) enzyme inducing compound, was selected because of its documented ability to induce phase 2 enzyme activity in rodent tissues in vivo and for comparison to the other compounds since it increased NQO1 activity to a lesser degree in the prostate cells in vitro [15].
Positive_regulation (increased) of NQO1
17) Confidence 0.47 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.16 Pain Relevance 0
Moreover, NQO1 gene silencing in HeLa cells by transfection of a small interfering RNA resulted in lowering of both the NQO1 protein level and the NQO1 activity by about 75%.
Positive_regulation (lowering) of NQO1 in HeLa
18) Confidence 0.47 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
Moreover, NQO1 gene silencing in HeLa cells by transfection of a small interfering RNA resulted in lowering of both the NQO1 protein level and the NQO1 activity by about 75%.
Positive_regulation (lowering) of NQO1 in HeLa
19) Confidence 0.47 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
A greater percentage of the neurons observed under bright field illumination were visible under dark field illumination at 6 h (47%) compared to control (18%), suggesting an increase in the enzymatic activity of neurons in laminae I-III in addition to the increase in the number of neurons with threshold levels of NADPH-diaphorase activity.
Positive_regulation (increase) of NADPH-diaphorase in neurons
20) Confidence 0.47 Published 1994 Journal Brain Res. Section Abstract Doc Link 8069693 Disease Relevance 0.26 Pain Relevance 0.25

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