INT103841

Context Info Confidence 0.43 First Reported 2002 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.93 Pain Relevance 0.63

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr) protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)

Anatomy Link Frequency CPAE 2 Cftr (Rattus norvegicus)

Pain Link Frequency Relevance Heat fibrosis 24 100.00 Inflammation 67 99.84 Prostatitis 136 94.48 tetrodotoxin 1 84.12 fluoxetine 1 55.88 cytokine 26 5.00 ischemia 6 5.00 addiction 5 5.00 Inflammatory response 4 5.00 adenocard 3 5.00

Disease Link Frequency Relevance Heat Cystic Fibrosis 24 100.00 INFLAMMATION 71 99.84 Benign Prostatic Hypertrophy 6 99.60 Pressure And Volume Under Development 27 96.04 Prostatitis 136 94.48 Bacterial Infection 46 84.96 Colitis 1 58.20 Bacterial Respiratory Disease 6 32.16 Infection 10 5.00 Hypoxia 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of the cystic fibrosis transmembrane conductance regulator (CFTR), as assessed by Northern blotting, was unchanged. cAMP levels in isolated colonocytes were markedly reduced by inflammation.

Negative_regulation (reduced) of Gene_expression (expression) of CFTR associated with fibrosis, inflammation and cystic fibrosis

1) Confidence 0.43 Published 2002 Journal Pflugers Arch. Section Abstract Doc Link 12111246 Disease Relevance 0.43 Pain Relevance 0.27

We thus examined CFTR and CAII expression in human prostate hyperplasia samples with inflammation.

Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of CFTR associated with benign prostatic hypertrophy and inflammation

2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.58 Pain Relevance 0.22

We further examined the expression of CFTR, CAII, IL-1?

Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of CFTR

3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.34 Pain Relevance 0.09

Heterologous expression of CFTR was shown to downregulate VSOR anion channel activity in CPAE and COS cells [116] as well as in HEK293T cells [117], but upregulate swelling-induced ATP release from C127/CFTR cells [58, 60].

Negative_regulation (downregulate) of Gene_expression (expression) of CFTR in CPAE associated with pressure and volume under development

4) Confidence 0.22 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.59 Pain Relevance 0.06

General Comments

This test has worked.