INT103842

Context Info Confidence 0.78 First Reported 2000 Last Reported 2010 Negated 1 Speculated 7 Reported most in Body Documents 53 Total Number 88 Disease Relevance 59.59 Pain Relevance 21.82

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr) protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)

Anatomy Link Frequency epithelial cells 10 pancreas 6 vas deferens 3 kidney 2 lymphocytes 2 Cftr (Rattus norvegicus) Cftr - Q1352H (2)

Pain Link Frequency Relevance Heat fibrosis 1119 100.00 cytokine 440 99.96 Inflammation 1075 99.88 Chronic pancreatitis 135 99.88 Prostatitis 2244 99.86 Inflammatory response 72 99.40 endometriosis 16 94.60 alcohol 1 93.16 Inflammatory mediators 4 91.84 tetrodotoxin 2 84.12

Disease Link Frequency Relevance Heat Cystic Fibrosis 1117 100.00 Disease 308 100.00 INFLAMMATION 1151 99.88 Pancreatitis 292 99.88 Prostatitis 2244 99.86 Bacterial Infection 763 99.70 Benign Prostatic Hypertrophy 99 99.60 Hyperplasia 66 99.60 Malignant Neoplastic Disease 99 98.88 Pressure And Volume Under Development 296 98.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of the cystic fibrosis transmembrane conductance regulator (CFTR), as assessed by Northern blotting, was unchanged. cAMP levels in isolated colonocytes were markedly reduced by inflammation.

Gene_expression (expression) of cystic fibrosis transmembrane conductance regulator associated with fibrosis, inflammation and cystic fibrosis

1) Confidence 0.78 Published 2002 Journal Pflugers Arch. Section Abstract Doc Link 12111246 Disease Relevance 0.42 Pain Relevance 0.26

The expression of the cystic fibrosis transmembrane conductance regulator (CFTR), as assessed by Northern blotting, was unchanged. cAMP levels in isolated colonocytes were markedly reduced by inflammation.

Gene_expression (expression) of CFTR associated with fibrosis, inflammation and cystic fibrosis

2) Confidence 0.78 Published 2002 Journal Pflugers Arch. Section Abstract Doc Link 12111246 Disease Relevance 0.42 Pain Relevance 0.26

CFTR expression has not been documented in osteoblasts or osteoclasts.

Gene_expression (expression) of CFTR in osteoclasts

3) Confidence 0.77 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.55 Pain Relevance 0.31

The expression profiles of trypsinogen, pancreas-specific trypsin inhibitor, cholecystokinin A receptor, cystic fibrosis transmembrane conductance regulator (CFTR), carbonic anhydrase, and Muc1 and Muc4 mucins transcripts were analyzed by RNA slot blot analysis.

Spec (analyzed) Gene_expression (expression) of CFTR in pancreas

4) Confidence 0.75 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0

The expression of carbonic anhydrase and CFTR remained unaltered when inflammatory signs were not detected in histological examinations.

Gene_expression (expression) of CFTR

5) Confidence 0.75 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0

The expression profiles of trypsinogen, pancreas-specific trypsin inhibitor, cholecystokinin A receptor, cystic fibrosis transmembrane conductance regulator (CFTR), carbonic anhydrase, and Muc1 and Muc4 mucins transcripts were analyzed by RNA slot blot analysis.

Spec (analyzed) Gene_expression (expression) of cystic fibrosis transmembrane conductance regulator in pancreas

6) Confidence 0.75 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0

CFTR(inh)-172 acutely produces CFTR dysfunction in rodents for up to 24 h.

Gene_expression (produces) of CFTR

7) Confidence 0.68 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.73 Pain Relevance 0.22

CFTR(inh)-172 acutely produces CFTR dysfunction in rodents for up to 24 h.

Gene_expression (produces) of CFTR

8) Confidence 0.67 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.73 Pain Relevance 0.22

It is clear from these atypical presentations of CFTR dysfunction that it is the vas deferens, pancreas, and sinuses that are the tissues most sensitive to decreases in CFTR function.

Gene_expression (dysfunction) of CFTR in vas deferens

9) Confidence 0.67 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.05 Pain Relevance 0.24

Furthermore, greater attention to 'adult' CF has also led us to identify, with increased frequency, atypical presentations of dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR): chronic pancreatitis, congenital bilateral absence of the vas deferens (CBAVD), chronic sinusitis, and allergic bronchopulmonary aspergillosis.

Gene_expression (dysfunction) of CFTR in vas deferens associated with fibrosis, sinusitis, cystic fibrosis, aspergillus infection and chronic pancreatitis

10) Confidence 0.67 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.53 Pain Relevance 0.58

A prime example of an area in which this question should be asked is the role of CFTR dysfunction in increasing the risk for malignancy.

Gene_expression (dysfunction) of CFTR associated with malignant neoplastic disease

11) Confidence 0.67 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.65 Pain Relevance 0.41

This has occurred in particular in isolated presentations of CFTR-related diseases such as CBAVD, chronic pancreatitis, and chronic sinusitis with nasal polyposis.

Gene_expression (diseases) of CFTR-related in nasal associated with sinusitis, nasal polyps, disease and chronic pancreatitis

12) Confidence 0.67 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.32 Pain Relevance 0.28

Do these unique presentations and chronic complications of adult CF teach us anything about the function of CFTR?

Gene_expression (function) of CFTR associated with fibrosis

13) Confidence 0.67 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.56 Pain Relevance 0.52

The manifestation of CFTR dysfunction in the pancreas is determined by the degree of decrease in CFTR levels, with a decrease to 10% of normal leading to an increased risk for pancreatitis, and a decrease to levels less than 1% leading invariably to exocrine pancreatic insufficiency.

Gene_expression (dysfunction) of CFTR in pancreas associated with exocrine pancreatic insufficiency and pancreatitis

14) Confidence 0.67 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 0.79 Pain Relevance 0.08

When deciding whether the complications of adult CF provide us with insight into CFTR function, the key question to ask is: do these complications suggest previously unrecognized functions for CFTR, or are they due to the long-term absence of already recognized CFTR functions?

Gene_expression (function) of CFTR associated with fibrosis

15) Confidence 0.67 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.64 Pain Relevance 0.50

Furthermore, greater attention to 'adult' CF has also led us to identify, with increased frequency, atypical presentations of dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR): chronic pancreatitis, congenital bilateral absence of the vas deferens (CBAVD), chronic sinusitis, and allergic bronchopulmonary aspergillosis.

Gene_expression (dysfunction) of cystic fibrosis transmembrane conductance regulator in vas deferens associated with fibrosis, sinusitis, cystic fibrosis, aspergillus infection and chronic pancreatitis

16) Confidence 0.67 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.52 Pain Relevance 0.57

DNA analyses of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in Japanese patients with idiopathic chronic pancreatitis (ICP) were performed to determine the relationship between the CFTR mutation and ICP.

Gene_expression (mutation) of CFTR associated with fibrosis, cystic fibrosis and chronic pancreatitis

17) Confidence 0.67 Published 2009 Journal J. Int. Med. Res. Section Abstract Doc Link 19383231 Disease Relevance 0.85 Pain Relevance 0.66

A rigorous search was conducted for other mutations in patients with one CFTR mutation, and CFTR function in nasal epithelia was assessed in vivo in patients with ICP [17].

Gene_expression (mutation) of CFTR in nasal associated with chronic pancreatitis

18) Confidence 0.67 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 1.46 Pain Relevance 1.00

The airway epithelial cell, which normally expresses the cystic fibrosis transmembrane conductance regulator (CFTR), directs the inflammatory response.

Gene_expression (expresses) of CFTR in epithelial cell associated with fibrosis, inflammatory response and cystic fibrosis

19) Confidence 0.67 Published 2002 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 12162106 Disease Relevance 1.65 Pain Relevance 0.55

The airway epithelial cell, which normally expresses the cystic fibrosis transmembrane conductance regulator (CFTR), directs the inflammatory response.

Gene_expression (expresses) of cystic fibrosis transmembrane conductance regulator in epithelial cell associated with fibrosis, inflammatory response and cystic fibrosis

20) Confidence 0.67 Published 2002 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 12162106 Disease Relevance 1.65 Pain Relevance 0.55

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