INT103843

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 2.31
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) aging (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
blood 3
neurons 2
cerebrospinal fluid 1
Ccr5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 3 99.98 Very High Very High Very High
Neuritis 4 99.96 Very High Very High Very High
Multiple sclerosis 2 99.58 Very High Very High Very High
cytokine 10 99.02 Very High Very High Very High
Demyelination 47 98.52 Very High Very High Very High
chemokine 121 98.38 Very High Very High Very High
Lasting pain 8 97.88 Very High Very High Very High
Opioid 8 96.80 Very High Very High Very High
opiate 5 96.24 Very High Very High Very High
Central nervous system 9 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Optic Neuritis 4 99.96 Very High Very High Very High
Demyelinating Disease 50 99.58 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 99.54 Very High Very High Very High
Pain 27 97.88 Very High Very High Very High
Infection 2 97.24 Very High Very High Very High
Immunodeficiency 1 96.92 Very High Very High Very High
INFLAMMATION 8 87.48 High High
Nervous System Injury 28 85.76 High High
Neurological Disease 6 83.16 Quite High
Bacterial Infection 1 53.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opiates may also promote immunodeficiency virus infection by decreasing the secretion of alpha and beta chemokines (important inhibitory cytokines for the expression of HIV) and at the same time increasing the expression of chemoreceptors CCR5 and CCR3, coreceptors for the virus.
Positive_regulation (increasing) of Gene_expression (expression) of CCR5 associated with chemokine, acquired immune deficiency syndrome or hiv infection, opiate, infection, immunodeficiency and cytokine
1) Confidence 0.42 Published 2004 Journal Am J Ther Section Abstract Doc Link 15356431 Disease Relevance 0.53 Pain Relevance 1.27
Like CCR2, the CCR5 receptor function and its ligand, RANTES, were also strongly upregulated in DRG neurons in response to focal demyelination.
Positive_regulation (upregulated) of Gene_expression (function) of CCR5 receptor in neurons associated with demyelination
2) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.59 Pain Relevance 0.88
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Positive_regulation (augmented) of Gene_expression (expressing) of CCR5 in blood associated with multiple sclerosis, optic neuritis and neuritis
3) Confidence 0.25 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.60 Pain Relevance 0.56
Previously, our laboratory reported that activation of the mu-opioid receptor induced the expression of CCL2, CCL5, and CXCL10, as well as CCR5 and CXCR4.
Positive_regulation (induced) of Gene_expression (expression) of CCR5 associated with opioid receptor
4) Confidence 0.09 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.63
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Positive_regulation (augmented) of in cerebrospinal fluid Gene_expression (expressing) of CCR5 in blood associated with multiple sclerosis, optic neuritis and neuritis
5) Confidence 0.08 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.60 Pain Relevance 0.56

General Comments

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