INT103846

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.09
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
nerve 2
primary sensory neurons 2
Cxcr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 208 100.00 Very High Very High Very High
Central nervous system 3 98.32 Very High Very High Very High
Demyelination 94 98.08 Very High Very High Very High
Inflammation 5 88.40 High High
Sciatic nerve 30 84.16 Quite High
painful pain 8 76.72 Quite High
Neuritis 2 75.00 Quite High
Multiple sclerosis 1 75.00 Quite High
Lasting pain 16 73.72 Quite High
nociceptor 12 62.72 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 56 99.64 Very High Very High Very High
Injury 28 98.76 Very High Very High Very High
Demyelinating Disease 97 98.08 Very High Very High Very High
INFLAMMATION 11 88.40 High High
Neurological Disease 3 87.36 High High
Nociception 28 76.72 Quite High
Optic Neuritis 2 75.20 Quite High
Syndrome 2 74.12 Quite High
Pain 52 73.72 Quite High
Neuropathy 4 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pattern of neuronal expression of CXCR3 mRNA at POD14 following focal nerve demyelination did not change relative to naïve or sham-treated tissue, but the nerve injury did increase the intensity of CXCR3 mRNA expression in the DRG ipsilateral to the injury (Fig. 5C), as well as in the contralateral DRG (data not shown).
Regulation (intensity) of Gene_expression (expression) of CXCR3 mRNA in nerve associated with demyelination, nervous system injury and injury
1) Confidence 0.35 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.63 Pain Relevance 0.33
This behavior was accompanied by a bilateral increase in the numbers of primary sensory neurons expressing the chemokine receptors CCR2, CCR5, and CXCR4 by POD14, with no change in the pattern of CXCR3 expression.
Neg (no) Regulation (change) of Gene_expression (expression) of CXCR3 in primary sensory neurons associated with chemokine
2) Confidence 0.21 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2228278 Disease Relevance 0.92 Pain Relevance 0.69
Therefore we studied expression of Th1-related CCR5 and CXCR3 chemokine receptors in patients with MS and controls.
Regulation (controls) of Gene_expression (expression) of CXCR3 associated with chemokine
3) Confidence 0.21 Published 2002 Journal J. Neurol. Section Abstract Doc Link 12111306 Disease Relevance 0.55 Pain Relevance 0.51

General Comments

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