INT103847

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Context Info
Confidence 0.55
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.04
Pain Relevance 5.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) aging (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
neurons 2
nerve 2
blood 1
cerebrospinal fluid 1
peripheral nerves 1
Ccr5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1 99.98 Very High Very High Very High
Neuritis 6 99.96 Very High Very High Very High
chemokine 637 99.88 Very High Very High Very High
Multiple sclerosis 3 99.58 Very High Very High Very High
Inflammation 43 99.34 Very High Very High Very High
Demyelination 282 98.52 Very High Very High Very High
Lasting pain 48 97.88 Very High Very High Very High
Opioid 2 96.80 Very High Very High Very High
Central nervous system 9 95.96 Very High Very High Very High
Sciatic nerve 90 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 168 99.98 Very High Very High Very High
Optic Neuritis 6 99.96 Very High Very High Very High
Demyelinating Disease 291 99.58 Very High Very High Very High
INFLAMMATION 69 99.34 Very High Very High Very High
Pain 156 97.88 Very High Very High Very High
Neurological Disease 9 96.12 Very High Very High Very High
Injury 85 93.40 High High
Hyperalgesia 126 87.84 High High
Diabetic Retinopathy 32 82.96 Quite High
Spinal Stenosis 18 71.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, CCR5 may also be activated by a number of other chemokine ligands which we did not measure [52].
Positive_regulation (activated) of CCR5 associated with chemokine
1) Confidence 0.55 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.58 Pain Relevance 0.85
As with CCR2 expression in sensory neurons, CCR5 mRNA transcript levels were strongly increased in many sensory neurons ipsilateral and contralateral to the nerve injury at POD14 (Fig. 5D).
Positive_regulation (increased) of CCR5 mRNA in nerve associated with nervous system injury
2) Confidence 0.55 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.70 Pain Relevance 0.40
CCR2, CXCR4, CXCR3 and CCR5 upregulation in L4–L5 DRG after unilateral LPC-induced nerve demyelination
Positive_regulation (upregulation) of CCR5 in nerve associated with demyelination
3) Confidence 0.55 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.96 Pain Relevance 0.67
The chemokine SDF-1/CXCL12 and its receptor CXCR4 are constitutively expressed by peripheral nerves [3,27-29] and chemokines that activate CCR5 and CXCR3 receptors, such as RANTES and IP-10, are synthesized in association with neuroinflammatory responses [16,30].
Positive_regulation (activate) of CCR5 in peripheral nerves associated with chemokine
4) Confidence 0.55 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.37 Pain Relevance 0.57
As noted above, nearly every neuron in the DRG ipsilateral to the nerve injury upregulated CCR5.
Positive_regulation (upregulated) of CCR5 in neuron associated with nervous system injury
5) Confidence 0.48 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.74 Pain Relevance 0.04
Like CCR2, the CCR5 receptor function and its ligand, RANTES, were also strongly upregulated in DRG neurons in response to focal demyelination.
Positive_regulation (upregulated) of CCR5 receptor in neurons associated with demyelination
6) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.59 Pain Relevance 0.88
Patients with untreated MS had elevated percentages of CCR5 and CXCR3 expressing T cells vs. healthy controls (HC) in blood, and vs. other non-inflammatory neurological diseases (OND) patients in CSF.
Positive_regulation (elevated) of CCR5 in T cells associated with neurological disease and inflammation
7) Confidence 0.23 Published 2002 Journal J. Neurol. Section Abstract Doc Link 12111306 Disease Relevance 0.58 Pain Relevance 0.51
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Positive_regulation (augmented) of CCR5 in blood associated with multiple sclerosis, optic neuritis and neuritis
8) Confidence 0.23 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.60 Pain Relevance 0.56
Of the 15 inflammatory genes tested, 12 genes (C1-INH, CCR5, CD44, CHI3L1, HSPB1, JAK3, LGALS3, LGALS3BP, LAMA5, PEDF, STAT3, TIMP1) were reproducibly upregulated at 3 months (Figures 4 &5).
Positive_regulation (upregulated) of CCR5 associated with inflammation
9) Confidence 0.16 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.33 Pain Relevance 0.12
Previously, our laboratory reported that activation of the mu-opioid receptor induced the expression of CCL2, CCL5, and CXCL10, as well as CCR5 and CXCR4.
Positive_regulation (induced) of CCR5 associated with opioid receptor
10) Confidence 0.09 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.63
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Positive_regulation (augmented) of CCR5 in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
11) Confidence 0.08 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.60 Pain Relevance 0.56

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