INT103848

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Context Info
Confidence 0.54
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 5
Disease Relevance 3.12
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
blood 1
nerve 1
cerebrospinal fluid 1
peripheral nerves 1
T cells 1
Cxcr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 216 99.88 Very High Very High Very High
Neuritis 6 99.78 Very High Very High Very High
Multiple sclerosis 3 99.40 Very High Very High Very High
Demyelination 94 98.04 Very High Very High Very High
Inflammation 7 97.04 Very High Very High Very High
Central nervous system 9 95.96 Very High Very High Very High
Pain 30 94.36 High High
hyperexcitability 10 94.00 High High
Hyperalgesia 28 88.24 High High
withdrawal 28 55.28 Quite High
Disease Link Frequency Relevance Heat
Optic Neuritis 6 99.78 Very High Very High Very High
Demyelinating Disease 99 99.40 Very High Very High Very High
INFLAMMATION 13 97.04 Very High Very High Very High
Neurological Disease 9 96.52 Very High Very High Very High
Pain 52 94.36 High High
Hyperalgesia 42 88.24 High High
Nervous System Injury 56 83.24 Quite High
Injury 28 43.52 Quite Low
Neuropathic Pain 34 5.00 Very Low Very Low Very Low
Nociception 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCR2, CXCR4, CXCR3 and CCR5 upregulation in L4–L5 DRG after unilateral LPC-induced nerve demyelination
Positive_regulation (upregulation) of CXCR3 in nerve associated with demyelination
1) Confidence 0.54 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.97 Pain Relevance 0.67
The chemokine SDF-1/CXCL12 and its receptor CXCR4 are constitutively expressed by peripheral nerves [3,27-29] and chemokines that activate CCR5 and CXCR3 receptors, such as RANTES and IP-10, are synthesized in association with neuroinflammatory responses [16,30].
Positive_regulation (activate) of CXCR3 in peripheral nerves associated with chemokine
2) Confidence 0.54 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.38 Pain Relevance 0.57
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Positive_regulation (augmented) of CXCR3 in blood associated with multiple sclerosis, optic neuritis and neuritis
3) Confidence 0.21 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.59 Pain Relevance 0.56
Patients with untreated MS had elevated percentages of CCR5 and CXCR3 expressing T cells vs. healthy controls (HC) in blood, and vs. other non-inflammatory neurological diseases (OND) patients in CSF.
Positive_regulation (elevated) of CXCR3 in T cells associated with neurological disease and inflammation
4) Confidence 0.09 Published 2002 Journal J. Neurol. Section Abstract Doc Link 12111306 Disease Relevance 0.59 Pain Relevance 0.52
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Positive_regulation (augmented) of CXCR3 in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
5) Confidence 0.07 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.59 Pain Relevance 0.56

General Comments

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