INT103849

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 1.90
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
blood 3
nerve 2
cerebrospinal fluid 1
Cxcr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 4 99.78 Very High Very High Very High
Multiple sclerosis 2 99.40 Very High Very High Very High
Demyelination 47 98.34 Very High Very High Very High
chemokine 111 98.16 Very High Very High Very High
Central nervous system 6 95.96 Very High Very High Very High
Inflammation 4 83.68 Quite High
Sciatic nerve 15 51.92 Quite High
Chronic pancreatitis 4 50.00 Quite Low
Pain 15 27.32 Quite Low
hyperexcitability 5 26.96 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 28 99.90 Very High Very High Very High
Optic Neuritis 4 99.78 Very High Very High Very High
Demyelinating Disease 50 99.40 Very High Very High Very High
Injury 14 98.76 Very High Very High Very High
Pancreatitis 4 85.72 High High
INFLAMMATION 7 83.68 Quite High
Neurological Disease 6 83.16 Quite High
Pain 26 27.32 Quite Low
Hyperalgesia 21 5.00 Very Low Very Low Very Low
Neuropathic Pain 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Real-time (RT)-PCR revealed increased expression of CXCL10 (13-fold) and CXCR3 (7-fold) in CP tissue.
Positive_regulation (increased) of Gene_expression (expression) of CXCR3
1) Confidence 0.40 Published 2007 Journal Pancreatology Section Body Doc Link 17912012 Disease Relevance 0.09 Pain Relevance 0
The pattern of neuronal expression of CXCR3 mRNA at POD14 following focal nerve demyelination did not change relative to naïve or sham-treated tissue, but the nerve injury did increase the intensity of CXCR3 mRNA expression in the DRG ipsilateral to the injury (Fig. 5C), as well as in the contralateral DRG (data not shown).
Positive_regulation (increase) of Gene_expression (expression) of CXCR3 mRNA in nerve associated with demyelination, nervous system injury and injury
2) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.63 Pain Relevance 0.33
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Positive_regulation (augmented) of Gene_expression (expressing) of CXCR3 in blood associated with multiple sclerosis, optic neuritis and neuritis
3) Confidence 0.23 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.59 Pain Relevance 0.56
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Positive_regulation (augmented) of in cerebrospinal fluid Gene_expression (expressing) of CXCR3 in blood associated with multiple sclerosis, optic neuritis and neuritis
4) Confidence 0.08 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.59 Pain Relevance 0.56

General Comments

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