INT103857

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Context Info
Confidence 0.23
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd5) plasma membrane (Drd5) signal transducer activity (Drd5)
Anatomy Link Frequency
striatum 1
Drd5 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 31 100.00 Very High Very High Very High
substance P 6 83.28 Quite High
projection neuron 4 83.04 Quite High
Ventral tegmentum 1 81.76 Quite High
Substantia nigra 2 79.72 Quite High
Enkephalin 6 75.60 Quite High
Neuropeptide 2 69.36 Quite High
adenocard 1 5.84 Low Low
Nucleus accumbens 9 5.00 Very Low Very Low Very Low
cocaine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 7 85.36 High High
Targeted Disruption 18 85.12 High High
Sprains And Strains 1 51.12 Quite High
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simple compensatory up-regulation of D5 DA receptors in response to D1 receptor subtype loss does not explain our findings, because genetic inactivation of the D1 DA receptor does not alter levels of D5 DA receptor expression.
Gene_expression (expression) of D5 DA receptor associated with dopamine
1) Confidence 0.23 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 12111832 Disease Relevance 0.92 Pain Relevance 0.58
The other DA receptors are less abundant in the striatum: the D3 receptor is mostly expressed in the ventral striatum (Diaz et al., 1995), the D5 receptor expression is low and widespread (Rivera et al., 2002), and the D4 receptor expression is not detected (NoaĆ­n et al., 2006).
Gene_expression (expression) of D5 receptor in striatum associated with dopamine
2) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.50

General Comments

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