INT103859

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.81
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd5) plasma membrane (Drd5) signal transducer activity (Drd5)
Anatomy Link Frequency
neurons 1
Drd5 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 216 100.00 Very High Very High Very High
gABA 48 96.24 Very High Very High Very High
GABAergic 36 91.68 High High
agonist 48 79.36 Quite High
antagonist 22 79.00 Quite High
dopamine receptor 58 73.44 Quite High
substance P 1 35.04 Quite Low
Enkephalin 1 27.36 Quite Low
projection neuron 3 25.00 Low Low
Neuropeptide 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 99.00 Very High Very High Very High
Disease 51 91.96 High High
Congenital Anomalies 4 59.28 Quite High
Parkinson's Disease 42 55.52 Quite High
Sprains And Strains 1 25.00 Low Low
Attention Deficit Hyperactivity Disorder 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Movement Disorders 4 5.00 Very Low Very Low Very Low
Tourette's Syndrome 2 5.00 Very Low Very Low Very Low
Fatigue 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of postsynaptic D5-receptors and subsequent activation of GPi cells may also occur, counteracting some of the changes in GABA release induced by presynaptic D1LR activation.
Positive_regulation (Activation) of D5-receptor associated with gaba
1) Confidence 0.49 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.11 Pain Relevance 0.45
This was specifically demonstrated for postsynaptic D5-receptors whose activation appears to potentiate burst firing in a subgroup of STN neurons (Baufreton et al., 2003).
Positive_regulation (activation) of D5-receptor in neurons
2) Confidence 0.49 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.42
In parallel, a robust increase in the striatal D5 DA receptor subtype occurred in the transgenic compared with the wild-type control mice.
Positive_regulation (increase) of D5 DA receptor associated with targeted disruption and dopamine
3) Confidence 0.21 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 12111832 Disease Relevance 0.70 Pain Relevance 0.27

General Comments

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