INT103870

Context Info Confidence 0.14 First Reported 2002 Last Reported 2002 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0.83 Pain Relevance 0.64

cytosol (IRF6, Hmox1) nucleus (IRF6, Hmox1) endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) DNA binding (IRF6) signal transducer activity (Hmox1)

IRF6 (Homo sapiens) Hmox1 (Mus musculus)

Pain Link Frequency Relevance Heat aspirin 3 99.12 cINOD 3 98.96 Inflammation 9 76.20

Disease Link Frequency Relevance Heat INFLAMMATION 9 76.20 Death 12 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

And, NSAIDs aspirin and diclofenase dose dependently inhibited LPS/IFN-gamma-induced HO-1 protein accompanied by suppression of PGE(2) (not NO) production.

LPS Neg (NO) Positive_regulation (induced) of HO-1 protein associated with aspirin and cinod

1) Confidence 0.14 Published 2002 Journal J. Cell. Biochem. Section Abstract Doc Link 12112002 Disease Relevance 0.33 Pain Relevance 0.24

L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production.

LPS Positive_regulation (induced) of HO-1 protein

2) Confidence 0.10 Published 2002 Journal J. Cell. Biochem. Section Abstract Doc Link 12112002 Disease Relevance 0.27 Pain Relevance 0.21

In the presence of lipopolysaccharide and interferon-gamma (LPS/IFN-gamma), HO-1 protein was induced slightly but significantly, and SNP, SP-NO, and PGE(2) enhanced HO-1 protein induced by LPS/IFN-gamma.

LPS Positive_regulation (induced) of HO-1 protein

3) Confidence 0.09 Published 2002 Journal J. Cell. Biochem. Section Abstract Doc Link 12112002 Disease Relevance 0.22 Pain Relevance 0.20

General Comments

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