INT103870

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Context Info
Confidence 0.14
First Reported 2002
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.83
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6, Hmox1) nucleus (IRF6, Hmox1) endoplasmic reticulum (Hmox1)
enzyme binding (Hmox1) DNA binding (IRF6) signal transducer activity (Hmox1)
IRF6 (Homo sapiens)
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 3 99.12 Very High Very High Very High
cINOD 3 98.96 Very High Very High Very High
Inflammation 9 76.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 76.20 Quite High
Death 12 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
And, NSAIDs aspirin and diclofenase dose dependently inhibited LPS/IFN-gamma-induced HO-1 protein accompanied by suppression of PGE(2) (not NO) production.
LPS Neg (NO) Positive_regulation (induced) of HO-1 protein associated with aspirin and cinod
1) Confidence 0.14 Published 2002 Journal J. Cell. Biochem. Section Abstract Doc Link 12112002 Disease Relevance 0.33 Pain Relevance 0.24
L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production.
LPS Positive_regulation (induced) of HO-1 protein
2) Confidence 0.10 Published 2002 Journal J. Cell. Biochem. Section Abstract Doc Link 12112002 Disease Relevance 0.27 Pain Relevance 0.21
In the presence of lipopolysaccharide and interferon-gamma (LPS/IFN-gamma), HO-1 protein was induced slightly but significantly, and SNP, SP-NO, and PGE(2) enhanced HO-1 protein induced by LPS/IFN-gamma.
LPS Positive_regulation (induced) of HO-1 protein
3) Confidence 0.09 Published 2002 Journal J. Cell. Biochem. Section Abstract Doc Link 12112002 Disease Relevance 0.22 Pain Relevance 0.20

General Comments

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