INT103880

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.57
Pain Relevance 5.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
striatum 2
nerve 1
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 493 100.00 Very High Very High Very High
rapifen 10 99.98 Very High Very High Very High
dopamine receptor 19 99.96 Very High Very High Very High
Migraine 2 99.74 Very High Very High Very High
Inflammation 78 99.68 Very High Very High Very High
agonist 32 99.28 Very High Very High Very High
cocaine 22 98.56 Very High Very High Very High
Opioid 7 98.04 Very High Very High Very High
positron emission tomography 105 97.92 Very High Very High Very High
antagonist 15 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 3 99.74 Very High Very High Very High
INFLAMMATION 78 99.68 Very High Very High Very High
Disease 151 99.50 Very High Very High Very High
Neuropathic Pain 7 96.48 Very High Very High Very High
Nociception 39 96.00 Very High Very High Very High
Pain 64 95.96 Very High Very High Very High
Toxicity 4 92.60 High High
Parkinsonian Disorders 78 91.36 High High
Adverse Drug Reaction 5 84.92 Quite High
Liver Disease 24 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Postsynaptic D2-dopamine receptors (D2Rs) either are not affected or are increased in the striatum of untreated PD patients (Antonini et al. 1994; Brooks et al. 1992; Rinne et al. 1990).
Neg (not) Positive_regulation (increased) of D2R in striatum associated with dopamine receptor and disease
1) Confidence 0.67 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.80 Pain Relevance 0.69
Importantly, PD patients have normal or increased levels of D2R in the striatum (Table 2).
Positive_regulation (increased) of D2R in striatum associated with disease
2) Confidence 0.63 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.74 Pain Relevance 0.47
Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man.
Positive_regulation (increases) of dopamine D2 receptor associated with rapifen and dopamine
3) Confidence 0.50 Published 2002 Journal Synapse Section Title Doc Link 12112410 Disease Relevance 0.14 Pain Relevance 0.99
In contrast powerful D2 agonists like bromocryptine show a heightened activation of the reward circuitry only in DRD2 A1 allele carriers.
Positive_regulation (activation) of DRD2 associated with agonist
4) Confidence 0.50 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.50 Pain Relevance 0.85
Genetic studies on migraine suggested a role of CACNA1A and DRD2 genes as susceptibility genes in this disorder.
Positive_regulation (role) of DRD2 associated with migraine
5) Confidence 0.49 Published 2003 Journal Neurol. Sci. Section Abstract Doc Link 12811615 Disease Relevance 0.89 Pain Relevance 0.23
Activation of the DRD2/mRNA results in a negative feedback that promotes an enhancement of mRNA directed D2 receptor proliferation.
Positive_regulation (Activation) of DRD2
6) Confidence 0.45 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.06 Pain Relevance 0.65
As opposed to this result, mRNA levels of D2R were increased in the inflammation group by 88% (t = -22.468, P < 0.001) (Figure 4).


Positive_regulation (increased) of D2R associated with inflammation
7) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2994804 Disease Relevance 0.84 Pain Relevance 0.75
D2R activation with a selective agonist, as well as D1R blockade with antagonists in the IC, diminish neuropathic nociception in a nerve transection model.
Positive_regulation (activation) of D2R in nerve associated with nociception, antagonist, neuropathic pain and agonist
8) Confidence 0.15 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2994804 Disease Relevance 0.63 Pain Relevance 0.38
These results also showed the increase in dopaminergic mediated inhibition by an increase in D2R's and a decrease in D1R's mRNA.
Positive_regulation (increase) of D2R
9) Confidence 0.13 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2994804 Disease Relevance 0.75 Pain Relevance 0.62
Eight-month treatment with oral methylphenidate beginning in adolescence decreased cocaine self-administration (1 mg/kg) during adulthood which could reflect the increases in D2R availability observed at this life stage since D2R increases are associated with reduced propensity for cocaine self-administration.
Positive_regulation (increases) of D2R associated with cocaine
10) Confidence 0.11 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.07 Pain Relevance 0.30
High prevalence of A23 and DR2 alleles in CDMS patients compared with the normal population may suggest an important role for these alleles in the development of MS.
Positive_regulation (prevalence) of DR2
11) Confidence 0.10 Published 2004 Journal Mult. Scler. Section Body Doc Link 15471368 Disease Relevance 0.14 Pain Relevance 0

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