INT103881

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.01
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
striatum 2
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 100 100.00 Very High Very High Very High
dopamine receptor 22 100.00 Very High Very High Very High
rapifen 20 99.98 Very High Very High Very High
Opioid 8 98.36 Very High Very High Very High
positron emission tomography 22 94.48 High High
Pain score 2 92.44 High High
opioid receptor 4 91.44 High High
agonist 4 90.80 High High
Nicotine 184 82.16 Quite High
Pain 4 71.48 Quite High
Disease Link Frequency Relevance Heat
Stress 2 93.52 High High
Pain 6 92.16 High High
Nicotine Addiction 344 88.68 High High
Substance Withdrawal Syndrome 6 30.40 Quite Low
Depression 20 18.48 Low Low
Drug Dependence 8 9.04 Low Low
Alcohol Addiction 20 5.00 Very Low Very Low Very Low
Neurosis 14 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man.
Positive_regulation (increases) of dopamine D2 receptor Binding (binding) of associated with rapifen and dopamine
1) Confidence 0.69 Published 2002 Journal Synapse Section Title Doc Link 12112410 Disease Relevance 0.14 Pain Relevance 1.00
These results indicate that pharmacologically relevant concentrations of alfentanil increase D2 dopamine receptor binding in the striatum in man.
Positive_regulation (increase) of D2 dopamine receptor Binding (binding) of in striatum associated with rapifen and dopamine receptor
2) Confidence 0.50 Published 2002 Journal Synapse Section Abstract Doc Link 12112410 Disease Relevance 0.23 Pain Relevance 0.86
Interestingly, despite disagreement regarding the direction of the association of the SLC6A3-9 allele, studies agree that there seems to be a significant interaction between this gene and DRD2-A1 in increasing susceptibility to tobacco use [103,108].
Positive_regulation (increasing) of DRD2 Binding (interaction) of
3) Confidence 0.20 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.82 Pain Relevance 0.16
Interestingly, despite disagreement regarding the direction of the association of the SLC6A3-9 allele, studies agree that there seems to be a significant interaction between this gene and DRD2-A1 in increasing susceptibility to tobacco use [103,108].
Positive_regulation (increasing) of DRD2 Binding (interaction) of
4) Confidence 0.20 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.82 Pain Relevance 0.16

General Comments

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