INT103888

Context Info Confidence 0.58 First Reported 2002 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 1.69 Pain Relevance 0.59

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)

Anatomy Link Frequency brain 2 bladder 1 Atf2 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 95.84 cINOD 3 94.16 Enkephalin 4 88.32 Dynorphin 1 84.72 opioid receptor 6 80.64 Inflammation 84 54.96 metalloproteinase 3 35.36 Inflammatory response 8 26.44 palliative 1 13.40 interstitial cystitis 6 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 6 99.78 Overactive Bladder 122 99.16 INFLAMMATION 97 93.76 Polycystic Kidney Disease 2 90.16 Hepatocellular Cancer 36 86.24 Schizophrenia 2 86.00 Stress 18 85.88 Apoptosis 49 79.88 Neurodegenerative Disease 4 79.88 Metastasis 6 75.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inducible transgenic mice that express either a dominant negative mutant form of the cAMP response element binding protein (mCREB) or CREB, in discrete brain regions, were used in this study.

Neg (negative) Gene_expression (express) of cAMP response element binding protein in brain associated with targeted disruption

1) Confidence 0.58 Published 2002 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 12113781 Disease Relevance 0.10 Pain Relevance 0.13

Overexpression of CREB or ATF-2 increased not only reporter promoter activity but also endogenous Sult4a1 mRNA levels in Neuro2a cells.

Gene_expression (Overexpression) of ATF-2

2) Confidence 0.56 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.14 Pain Relevance 0.19

Regulation of mouse brain-selective sulfotransferase sult4a1 by cAMP response element-binding protein and activating transcription factor-2.

Gene_expression (sulfotransferase) of cAMP response element-binding protein in brain

3) Confidence 0.49 Published 2010 Journal Mol. Pharmacol. Section Title Doc Link 20571078 Disease Relevance 0.17 Pain Relevance 0

Downstream substrates of the p38 MAPKs include protein kinases such as MAPK-activated protein kinase 2 (MAPKAPK2) [18] and p38 regulated/activated kinase (PRAK/MAPKAPK5) [19], as well as several transcription factors including MEF2, CHOP, and ATF2 [10].

Gene_expression (include) of ATF2

4) Confidence 0.48 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.18 Pain Relevance 0.19

SF-1 and CRE-BP1 were found upstream of sac1 (a murine homolog of S. cerevisiae suppressor of actin mutations).

Gene_expression (found) of CRE-BP1

5) Confidence 0.27 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.37 Pain Relevance 0

Activation of MAPK regulates the activities of a number of substrates including transcription factor p62TCF (Elk-1), c-myc, ATF2 and AP-1 components, c-Jun and c-fos [20].

Gene_expression (components) of ATF2

6) Confidence 0.25 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.42 Pain Relevance 0

The regulatory network for the control bladder mucosa (MC) was obtained in comparison to detrusor control and contained the following over-represented TREs: GA-binding protein (GABP), YY1 (yin yang 1), SF-1 (steroidogenic factor-1), EF2, CRE-BP1, and Sp-3 (trans-acting transcription factor 3).

Gene_expression (represented) of CRE-BP1 in bladder associated with overactive bladder

7) Confidence 0.24 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.31 Pain Relevance 0.08

General Comments

This test has worked.