INT103899

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 7.85
Pain Relevance 5.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ERCC2) aging (ERCC2) chromosome segregation (ERCC2)
helicase activity (ERCC2) extracellular matrix organization (ERCC2) DNA binding (ERCC2)
Anatomy Link Frequency
EM-2 8
central nervous system 2
liver 1
ERCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 1 99.86 Very High Very High Very High
Central nervous system 4 99.84 Very High Very High Very High
Arthritis 29 99.56 Very High Very High Very High
Opioid 7 99.42 Very High Very High Very High
Morphine 8 97.96 Very High Very High Very High
Analgesic 9 96.64 Very High Very High Very High
Root ganglion neuron 1 96.28 Very High Very High Very High
Spinal nerve ligature 1 95.68 Very High Very High Very High
antagonist 2 95.48 Very High Very High Very High
agonist 1 94.52 High High
Disease Link Frequency Relevance Heat
Hutchinson-gilford Progeria Syndrome 82 100.00 Very High Very High Very High
Ganglion Cysts 2 99.86 Very High Very High Very High
Pituitary Cancer 2 99.84 Very High Very High Very High
Experimental Arthritis 27 99.56 Very High Very High Very High
Aging 68 97.32 Very High Very High Very High
Rheumatoid Arthritis 16 96.96 Very High Very High Very High
Osteoarthritis 10 96.68 Very High Very High Very High
Ataxia 16 95.64 Very High Very High Very High
Neuropathic Pain 3 94.44 High High
Tremor 2 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EM-1 was detectable in five of eight samples of synovial tissue from inflamed hind paws, whereas EM-2 was detectable in two of eight synovial extracts.
Gene_expression (detectable) of EM-1 in EM-2
1) Confidence 0.65 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.53 Pain Relevance 0.45
EM-1 was detectable in five of eight samples of synovial tissue from inflamed hind paws, whereas EM-2 was detectable in two of eight synovial extracts.
Gene_expression (detectable) of EM-2 in EM-2
2) Confidence 0.65 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.52 Pain Relevance 0.45
Neither EM-1 nor EM-2 were detectable in synovial tissue from non-AA rats.
Gene_expression (detectable) of EM-1 in EM-2 associated with arthritis
3) Confidence 0.65 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.52 Pain Relevance 0.45
PBLs from three normal human subjects contained 248, 13, and 303 pg EM-1 per 100 million cells, whereas EM-2 was measured in two subjects at 69 and 588 pg per 100 million cells.
Gene_expression (contained) of EM-1 in EM-2
4) Confidence 0.56 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.51 Pain Relevance 0.37
EM-1 produced a more rapid internalization of mu receptors than morphine, but hypertonic sucrose blocked the internalization induced by each of these agonists.
Gene_expression (produced) of EM-1 associated with agonist and morphine
5) Confidence 0.55 Published 2004 Journal Brain Res. Section Abstract Doc Link 15527737 Disease Relevance 0.14 Pain Relevance 1.04
Neither EM-1 nor EM-2 were detectable in synovial tissue from non-AA rats.
Gene_expression (detectable) of EM-2 in EM-2 associated with arthritis
6) Confidence 0.50 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.52 Pain Relevance 0.45
METHODS: We established a highly sensitive radioimmunoassay to detect EM-1 and EM-2.
Gene_expression (detect) of EM-1 in EM-2
7) Confidence 0.41 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18240240 Disease Relevance 0.29 Pain Relevance 0
METHODS: We established a highly sensitive radioimmunoassay to detect EM-1 and EM-2.
Gene_expression (detect) of EM-2 in EM-2
8) Confidence 0.41 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18240240 Disease Relevance 0.29 Pain Relevance 0
Subcutaneous inoculation of vEM2 resulted in vector delivery to dorsal root ganglion where expression of EM-2 peptide from the engineered gene was confirmed by ELISA. vEM2 delivery provided an analgesic effect in the spinal nerve ligation model of neuropathic pain measured by reduction of mechanical allodynia and thermal hyperalgesia.
Gene_expression (expression) of EM-2 in EM-2 associated with ganglion cysts, dorsal root ganglion, allodynia, thermal hyperalgesia, spinal nerve ligature, analgesic and neuropathic pain
9) Confidence 0.29 Published 2007 Journal Pain Section Abstract Doc Link 17395375 Disease Relevance 0.85 Pain Relevance 0.98
We utilized a cell line from a patient of the XPD complementation group [61], mutant in the ERCC2 DNA helicase [62], and a control line in which the mutation was restored to the wild type by a transfected ERCC2 expression construct [63], and tested for sensitivity to compound 15, compound 13, and cisplatin.
Gene_expression (expression) of ERCC2
10) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.18 Pain Relevance 0.04
For both cisplatin and compound 15, expression of ERCC2 (XPD+ERCC2) rescued the sensitivity of the NER-defective XPD cell line (XPD; Figure 6E).
Gene_expression (expression) of ERCC2
11) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.17 Pain Relevance 0.04
For both cisplatin and compound 15, expression of ERCC2 (XPD+ERCC2) rescued the sensitivity of the NER-defective XPD cell line (XPD; Figure 6E).
Gene_expression (expression) of ERCC2
12) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.17 Pain Relevance 0.04
By contrast, sensitivity to compound 13 was not efficiently rescued by expression of ERCC2 (Figure S4).
Gene_expression (expression) of ERCC2
13) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.16 Pain Relevance 0.04
The opioid tetrapeptides endomorphins (EM)-1 and EM-2 are widely expressed in central nervous system and immune tissues of rats and humans.
Gene_expression (expressed) of EM in central nervous system associated with central nervous system and opioid
14) Confidence 0.23 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20398016 Disease Relevance 0.61 Pain Relevance 0.58
The opioid tetrapeptides endomorphins (EM)-1 and EM-2 are widely expressed in central nervous system and immune tissues of rats and humans.
Gene_expression (expressed) of EM in central nervous system associated with central nervous system and opioid
15) Confidence 0.23 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20398016 Disease Relevance 0.61 Pain Relevance 0.58
In support of this interpretation, end-of-life pathology in TTD mice is consistent with both segmental accelerated aging (e.g., increased lipofuscin accumulation in the liver) and calorie restriction (e.g., reduced incidence of pituitary adenomas) [53]; TTD liver gene expression also resembled that of long-lived dwarf mice (Y.
Gene_expression (expression) of TTD in liver associated with aging, pituitary cancer and hutchinson-gilford progeria syndrome
16) Confidence 0.02 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.90 Pain Relevance 0
However, unlike XPCS/XPA and TTD/XPA, CH/XPA mice survived the stressful weaning period with high penetrance (?
Gene_expression (/) of TTD associated with hutchinson-gilford progeria syndrome
17) Confidence 0.01 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.91 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox