INT10390

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Context Info
Confidence 0.56
First Reported 1985
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.33
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Asah1) cellular_component (Asah1) lipid metabolic process (Asah1)
lysosome (Asah1)
Anatomy Link Frequency
plasma 2
testis 1
spleen 1
Asah1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 8 97.86 Very High Very High Very High
Analgesic 1 96.90 Very High Very High Very High
Potency 3 96.56 Very High Very High Very High
Pain 1 91.40 High High
agonist 6 75.00 Quite High
adenocard 2 75.00 Quite High
Thermal hyperalgesia 2 71.52 Quite High
antagonist 4 63.68 Quite High
Hyperalgesia 2 48.16 Quite Low
narcan 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 4 98.76 Very High Very High Very High
Nociception 2 95.28 Very High Very High Very High
Hoarseness 1 93.64 High High
Farber Lipogranulomatosis 3 87.12 High High
Lysosome Storage Disease 1 82.32 Quite High
Hyperplasia 2 75.36 Quite High
Hyperalgesia 4 71.52 Quite High
Pressure And Volume Under Development 2 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The disease is inherited as an autosomal recessive trait, and mutations in the N-acylsphingosine amidohydrolase (ASAH1) gene, which codes for the acid ceramidase enzyme, have been shown to cause the disease.
Gene_expression (codes) of acid ceramidase enzyme associated with disease
1) Confidence 0.56 Published 2006 Journal J. Hum. Genet. Section Abstract Doc Link 16951918 Disease Relevance 0.71 Pain Relevance 0.09
AC-55541 and AC-264613 were well absorbed when administered intraperitoneally to rats, each reaching micromolar peak plasma concentrations.
Gene_expression (absorbed) of AC-264613 in plasma
2) Confidence 0.18 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18768780 Disease Relevance 0.31 Pain Relevance 0.24
AC-55541 and AC-264613 were well absorbed when administered intraperitoneally to rats, each reaching micromolar peak plasma concentrations.
Gene_expression (absorbed) of AC-55541 in plasma
3) Confidence 0.18 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18768780 Disease Relevance 0.31 Pain Relevance 0.24
With the aim of increasing the inhibitory potency of the analgesic dipeptide H-Trp(Nps)-Lys-OMe against enkephalin-degrading aminopeptidases, the following derivatives bearing chelating groups at the N-terminus have been synthesized: Ac-Trp(Nps)-Lys-OMe (3), HS(CH2)nCO-Trp(Nps)-Lys-OMe [n = 1 (4), n = 2 (5)], MeOCO(CH2)n-Trp(Nps)-Lys-OMe [n = 1 (6), n = 2 (7)] and analogues in which the N alpha-amino group has been replaced by a methoxycarbonyl group (8) and a bidentate hydroxamate function (9), respectively.
Gene_expression (synthesized) of Ac-Trp associated with analgesic, enkephalin and potency
4) Confidence 0.05 Published 1992 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 1489252 Disease Relevance 0 Pain Relevance 0.32
With the use of [125I]acetyl human beta-endorphin (Ac-hBE), specific binding sites for beta-endorphin (BE) were identified in the liver, kidney, adrenal, spleen, and testis of adult male rats, whereas specific BE-binding sites were not present in the ventral prostate or pancreas.
Neg (not) Gene_expression (present) of Ac-hBE in testis
5) Confidence 0.02 Published 1985 Journal Endocrinology Section Abstract Doc Link 2992912 Disease Relevance 0 Pain Relevance 0.04
With the use of [125I]acetyl human beta-endorphin (Ac-hBE), specific binding sites for beta-endorphin (BE) were identified in the liver, kidney, adrenal, spleen, and testis of adult male rats, whereas specific BE-binding sites were not present in the ventral prostate or pancreas.
Neg (not) Gene_expression (present) of Ac-hBE in spleen
6) Confidence 0.01 Published 1985 Journal Endocrinology Section Abstract Doc Link 2992912 Disease Relevance 0 Pain Relevance 0.04

General Comments

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