INT103900

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.47
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ERCC2) aging (ERCC2) chromosome segregation (ERCC2)
helicase activity (ERCC2) extracellular matrix organization (ERCC2) DNA binding (ERCC2)
Anatomy Link Frequency
spleen 2
thymus 2
ERCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 20 99.86 Very High Very High Very High
opioid receptor 4 85.80 High High
Inflammation 16 75.00 Quite High
Opioid 4 75.00 Quite High
rheumatoid arthritis 4 50.00 Quite Low
Osteoarthritis 4 50.00 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Endogenous opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hutchinson-gilford Progeria Syndrome 41 100.00 Very High Very High Very High
Experimental Arthritis 20 99.86 Very High Very High Very High
Apoptosis 142 97.68 Very High Very High Very High
Ataxia 8 95.28 Very High Very High Very High
Tremor 1 93.16 High High
Body Weight 10 91.68 High High
INFLAMMATION 18 75.00 Quite High
Dwarfism 25 50.00 Quite Low
Stress 22 50.00 Quite Low
Rheumatoid Arthritis 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In AA rats, EM-1 (but not EM-2) contents in the spleen and thymus were elevated compared with levels in tissues from non-AA controls.
Positive_regulation (elevated) of EM-2 in thymus associated with arthritis
1) Confidence 0.58 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.53 Pain Relevance 0.44
In AA rats, EM-1 (but not EM-2) contents in the spleen and thymus were elevated compared with levels in tissues from non-AA controls.
Positive_regulation (elevated) of EM-1 in thymus associated with arthritis
2) Confidence 0.58 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.54 Pain Relevance 0.45
Local enhancement of EM-1 might be an interesting therapeutic option in different forms of arthritis.


Positive_regulation (enhancement) of EM-1
3) Confidence 0.42 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18240240 Disease Relevance 0 Pain Relevance 0
XRCC4, XRCC5, ERCC2, RAD17, and RAD51, which are all key genes in DNA replication and repair [22-25], were induced.
Positive_regulation (induced) of ERCC2
4) Confidence 0.21 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.43 Pain Relevance 0
In AA rats, EM-1 (but not EM-2) contents in the spleen and thymus were elevated compared with levels in tissues from non-AA controls.
Positive_regulation (elevated) of EM-2 in spleen associated with arthritis
5) Confidence 0.20 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.53 Pain Relevance 0.44
In AA rats, EM-1 (but not EM-2) contents in the spleen and thymus were elevated compared with levels in tissues from non-AA controls.
Positive_regulation (elevated) of EM-1 in spleen associated with arthritis
6) Confidence 0.20 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114304 Disease Relevance 0.54 Pain Relevance 0.45
However, unlike XPCS/XPA and TTD/XPA, CH/XPA mice survived the stressful weaning period with high penetrance (?
Positive_regulation (/) of TTD associated with hutchinson-gilford progeria syndrome
7) Confidence 0.01 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.90 Pain Relevance 0

General Comments

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