INT103907

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 4.30
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Upf1) helicase activity (Upf1) cell cycle (Upf1)
DNA binding (Upf1) cytoplasm (Upf1)
Anatomy Link Frequency
ventricle 1
T cells 1
PBMC 1
Upf1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 74 92.92 High High
Serotonin 45 81.88 Quite High
fluoxetine 81 79.36 Quite High
Endep 51 78.16 Quite High
Arthritis 13 73.60 Quite High
Hippocampus 37 67.28 Quite High
Pain 6 65.72 Quite High
antidepressant 9 63.20 Quite High
depression 3 61.48 Quite High
Inflammation 74 54.44 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 221 99.24 Very High Very High Very High
Disease 131 98.12 Very High Very High Very High
Apoptosis 8 97.72 Very High Very High Very High
Sprains And Strains 26 96.08 Very High Very High Very High
Syndrome 142 93.04 High High
Rheumatoid Arthritis 75 92.92 High High
Adhesions 8 91.08 High High
Cancer 66 87.12 High High
Breast Cancer 10 85.48 High High
Experimental Arthritis 5 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was also a statistically significant decrease in tumor necrosis factor alpha transcripts in the PBMC.
Negative_regulation (decrease) of transcripts in PBMC
1) Confidence 0.37 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12115153 Disease Relevance 0 Pain Relevance 0
The treatment with siMEF2C was accompanied by marked reduction of MEF2C transcripts, but not of those from MEF2A, MEF2B or MEF2D (Figure 2C-F), after normalization to GAPDH.
Negative_regulation (reduction) of transcripts
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
We found reductions of MEF2C transcripts in the lung similar as to those of left ventricle from mice treated with siMEF2C (Figure 3D).
Negative_regulation (reductions) of transcripts in ventricle
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.22 Pain Relevance 0
Reduction in MEF2C transcripts and protein levels was also demonstrated to occur in banded mice treated with siMEF2C (Figure 2F, G).
Negative_regulation (Reduction) of transcripts
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
We reasoned that an increase in A and B site editing should lead to a decrease in transcripts that are unmodified at both sites (AA***), with a concomitant increase in deaminated transcripts (AG***, GA***, and/or GG***).
Negative_regulation (decrease) of transcripts
5) Confidence 0.01 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0.58
One commonly used and informative method is to individually sequence large numbers of transcripts (anywhere from 20 to 100 or more) (14,23,24).
Negative_regulation (numbers) of transcripts
6) Confidence 0.01 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.37 Pain Relevance 0.32
Interestingly, some of these ‘false transcripts’ occurred at higher frequencies than a number of the rarer transcripts that passed all the filters.
Negative_regulation (number) of transcripts
7) Confidence 0.01 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0
Further support for this idea is obtained by correlating fold-increase or -decrease of affected transcripts.
Negative_regulation (decrease) of transcripts
8) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.06 Pain Relevance 0
It is fascinating that the diverse and severe pathology observed in this study is caused by only a 25–35% decrease in the level of Nipbl transcripts (Figure 5; also see Table S2 and Table S3).
Negative_regulation (decrease) of transcripts
9) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.87 Pain Relevance 0
Oestriol treatment has also been shown to be effective in reducing clinical signs in EAE when administered after disease onset [129].
Negative_regulation (effective) of reducing associated with multiple sclerosis and disease
10) Confidence 0.01 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.30 Pain Relevance 0.19
Furthermore, the downregulation of NP-1 transcripts by short interfering RNA caused spontaneous synoviocyte apoptosis, which was associated with both a decrease in Bcl-2 expression and an increase in Bax translocation to mitochondria.
Negative_regulation (downregulation) of transcripts associated with apoptosis
11) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.74 Pain Relevance 0.25
Although bcr-abl transcripts increased considerably after the 12th administration of WT1 peptides, there was a gradual decrease of the transcripts thereafter to the level of complete molecular response after 11 months from the cessation of WT1 peptide administdration for 17 months (total administration: 22 times, every four-week administration: 11 times).
Negative_regulation (decrease) of transcripts
12) Confidence 0.01 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0 Pain Relevance 0
After the fourth administration of WT1 peptides, bcr-abl transcripts decreased to 820 copies with an increase in the frequency of WT1/MHC tetramer+CD8+ T cells in PB.
Negative_regulation (decreased) of transcripts in T cells
13) Confidence 0.01 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.29 Pain Relevance 0.07
Although bcr-abl transcripts rose up to 2,600 copies after 12th administration of WT1 peptides, thereafter the transcripts tended to decrease and fell to 400 copies after 22nd administration of WT1 peptides.
Negative_regulation (decrease) of transcripts
14) Confidence 0.01 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.15 Pain Relevance 0
By administration of WT1 peptides every two weeks in combination with the same amount of imatinib, the tendency of increase of bcr-abl transcripts was abrogated and the patient showed a slight decrease of bcr-abl transcripts after the 4th administration of WT1 peptides.
Negative_regulation (decrease) of transcripts
15) Confidence 0.01 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.30 Pain Relevance 0

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