INT10391

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nps)
Nps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 1 100.00 Very High Very High Very High
Potency 1 100.00 Very High Very High Very High
Enkephalin 4 99.64 Very High Very High Very High
Inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
narcan 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 1 91.64 High High
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent epidemiologic studies provide evidence that an increase in atmospheric nanoparticles (NPs) is associated with adverse cardiovascular effects in susceptible parts of populations (Ibald-Mulli et al. 2002; Wichmann and Peters 2000; Wichmann et al. 2000) such as the elderly and people with underlying diseases of various origins [U.S.
Positive_regulation (increase) of NPs associated with disease
1) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1867986 Disease Relevance 0.09 Pain Relevance 0
With the aim of increasing the inhibitory potency of the analgesic dipeptide H-Trp(Nps)-Lys-OMe against enkephalin-degrading aminopeptidases, the following derivatives bearing chelating groups at the N-terminus have been synthesized: Ac-Trp(Nps)-Lys-OMe (3), HS(CH2)nCO-Trp(Nps)-Lys-OMe [n = 1 (4), n = 2 (5)], MeOCO(CH2)n-Trp(Nps)-Lys-OMe [n = 1 (6), n = 2 (7)] and analogues in which the N alpha-amino group has been replaced by a methoxycarbonyl group (8) and a bidentate hydroxamate function (9), respectively.
Positive_regulation (increasing) of H-Trp(Nps)-Lys-OMe associated with analgesic, enkephalin and potency
2) Confidence 0.10 Published 1992 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 1489252 Disease Relevance 0 Pain Relevance 0.32

General Comments

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