INT103914

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Context Info
Confidence 0.82
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 16.98
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) Golgi apparatus (Egfr)
endoplasmic reticulum (Egfr) intracellular (Egfr) enzyme binding (Egfr)
Anatomy Link Frequency
MDA-MB-468 1
lung 1
Egfr (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 6 99.76 Very High Very High Very High
qutenza 24 99.60 Very High Very High Very High
opioid receptor 96 99.52 Very High Very High Very High
agonist 67 99.24 Very High Very High Very High
imagery 58 97.44 Very High Very High Very High
antagonist 135 96.36 Very High Very High Very High
substance P 16 91.44 High High
Inflammation 88 90.96 High High
positron emission tomography 32 87.56 High High
cINOD 10 85.28 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 351 99.52 Very High Very High Very High
Apoptosis 62 99.40 Very High Very High Very High
Breast Cancer 273 99.16 Very High Very High Very High
Endometriosis (extended) 12 99.04 Very High Very High Very High
Inflammatory Bowel Disease 33 98.44 Very High Very High Very High
Targeted Disruption 36 98.36 Very High Very High Very High
Non-small-cell Lung Cancer 133 97.12 Very High Very High Very High
Bone Cancer 6 96.76 Very High Very High Very High
Metastasis 136 95.84 Very High Very High Very High
Colitis 201 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, TKIs, by competitively binding to the ATP binding site of the intracellular domain of EGFR, inhibit EGFR autophosphorylation and impair downstream signaling, leading to cell cycle arrest and apoptosis in vitro (Moyer et al 1997; Pollack et al 1999; Arteaga 2001; Grunwald and Hidalgo 2003; Pao and Miller JCO 2005; Marshall 2006).
Phosphorylation (autophosphorylation) of EGFR associated with apoptosis
1) Confidence 0.82 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.34 Pain Relevance 0
A separate study showed that the TKI gefitinib completely inhibited EGF-induced cell proliferation as well as EGFR autophosphorylation and phosphorylation of MAPK in pancreatic cancer cell lines (Li et al 2004).
Phosphorylation (autophosphorylation) of EGFR associated with pancreatic cancer
2) Confidence 0.82 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.89 Pain Relevance 0
In two pancreatic cancer mouse xenograft models, erlotinib alone and in combination with gemcitabine significantly inhibited EGFR phosphorylation and increased apoptosis (Ng et al 2002).
Phosphorylation (phosphorylation) of EGFR associated with pancreatic cancer and apoptosis
3) Confidence 0.82 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.99 Pain Relevance 0
Dimerization results in autophosphorylation of EGFR C-terminal regulatory motifs and subsequent activation of downstream signaling.
Phosphorylation (autophosphorylation) of EGFR
4) Confidence 0.82 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.05 Pain Relevance 0.04
In vitro studies showed that these PEGylated derivative compounds had a high and irreversible potency to inhibit EGFR autophosphorylation [26, 27].
Phosphorylation (autophosphorylation) of EGFR associated with potency
5) Confidence 0.80 Published 2010 Journal Mol Imaging Biol Section Body Doc Link PMC2978890 Disease Relevance 0.55 Pain Relevance 0.18
TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.
Phosphorylation (phosphorylation) of EGFR associated with targeted disruption and qutenza
6) Confidence 0.80 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20660715 Disease Relevance 0.82 Pain Relevance 0.85
In vitro, ipriflavone inhibited the proliferation and DNA synthesis of MDA-231 cells and blocked the ligand-induced phosphorylation of Tyr(845) of the EGFR.
Phosphorylation (phosphorylation) of EGFR
7) Confidence 0.80 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12115517 Disease Relevance 1.24 Pain Relevance 0
We demonstrate in this model that lapatinib-mediated blockade of both EGFR and HER-2 phosphorylation causes downstream signaling alteration upon drug administration.
Phosphorylation (phosphorylation) of EGFR
8) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.48 Pain Relevance 0
Impact of EGFR or EGFRvIII on Survival
Phosphorylation (Impact) of EGFR
9) Confidence 0.75 Published 2005 Journal J Transl Med Section Body Doc Link PMC1298339 Disease Relevance 0.86 Pain Relevance 0
Increased EGFR tyrosine phosphorylation in the rectal mucosa of patients with UC has been reported [21].
Phosphorylation (phosphorylation) of EGFR associated with inflammatory bowel disease
10) Confidence 0.72 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.06 Pain Relevance 0.32
PGE 2 may induce EGFR phosphorylation through induction of EGFR ligands, or through intracellular mediators such as cAMP or PI 3 kinase [20].
Phosphorylation (phosphorylation) of EGFR
11) Confidence 0.72 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.03 Pain Relevance 0.33
The phosphorylation of ERK was reduced by tyrphostin AG1478, an inhibitor of phosphorylation of the epidermal growth factor receptor (EGFR), and by heparin, which neutralizes heparin-binding epithelial growth factor (HB-EGF), suggesting the involvement of a transactivation process, in which alpha(2)-adrenergic stimulation leads to proteolytic shedding of HB-EGF (and perhaps other EGFR agonists) from transmembrane-spanning precursors.
Phosphorylation (phosphorylation) of EGFR associated with agonist
12) Confidence 0.72 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834899 Disease Relevance 0.05 Pain Relevance 0.20
A separate study showed that the TKI gefitinib completely inhibited EGF-induced cell proliferation as well as EGFR autophosphorylation and phosphorylation of MAPK in pancreatic cancer cell lines (Li et al 2004).
Phosphorylation (phosphorylation) of EGFR associated with pancreatic cancer
13) Confidence 0.63 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.89 Pain Relevance 0
This was consistent with the hypothesis that the activation of the tyrosine phosphorylation response might be completely switched off if the number of EGFR dropped below a given threshold [31].
Phosphorylation (phosphorylation) of EGFR
14) Confidence 0.63 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.56 Pain Relevance 0.03
These authors reported that the autophosphorylation of Y350 in the EGFR does not occur after LPA exposure, suggesting that c-Src is the principal tyrosine kinase in this instance and not the EGFR's intrinsic tyrosine kinase.
Phosphorylation (autophosphorylation) of EGFR
15) Confidence 0.62 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.16
In the presence of the EGFR, ligand activation of LPA and ET-1 receptors did not increase EGFR phosphorylation even though both the LPA and ET-1 receptors stimulated ERK activity by 10-fold over basal [27].
Phosphorylation (phosphorylation) of EGFR
16) Confidence 0.62 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.13 Pain Relevance 0.17
ERK activation and EGFR phosphorylation via each of these receptors was inhibited by prior exposure to the EGFR kinase inhibitor, AG1478.
Phosphorylation (phosphorylation) of EGFR
17) Confidence 0.62 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.09
While the EGFR does not appear to be phosphorylated during DSLET-mediated ERK activation, it is possible that the EGFR is somehow involved in this response when it is present.
Phosphorylation (phosphorylated) of EGFR
18) Confidence 0.62 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.23 Pain Relevance 0.25
HEK-293 cells endogenously express the EGFR, and EGF produces robust ERK activation concomitant with EGFR tyrosine phosphorylation.
Phosphorylation (phosphorylation) of EGFR
19) Confidence 0.62 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.16 Pain Relevance 0.14
Src was found to co-immunoprecipitate with the phosphorylated EGFR in COS-7 cells exposed to either LPA or EGF [14].
Phosphorylation (phosphorylated) of EGFR
20) Confidence 0.62 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.11

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