INT103917

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.23
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) Golgi apparatus (Egfr)
endoplasmic reticulum (Egfr) intracellular (Egfr) enzyme binding (Egfr)
Egfr (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 12 99.74 Very High Very High Very High
agonist 40 99.72 Very High Very High Very High
substance P 10 92.04 High High
Inflammation 50 91.20 High High
endometriosis 2 86.08 High High
Dismenorea 2 85.48 High High
cINOD 4 80.28 Quite High
opioid receptor 60 79.16 Quite High
Opioid 115 76.56 Quite High
COX2 3 72.44 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 12 99.04 Very High Very High Very High
Pancreatic Cancer 70 98.72 Very High Very High Very High
Targeted Disruption 13 98.64 Very High Very High Very High
Inflammatory Bowel Disease 22 98.44 Very High Very High Very High
Apoptosis 15 97.60 Very High Very High Very High
Colitis 134 96.16 Very High Very High Very High
Neuroepithelial Neoplasms 9 94.44 High High
Cancer 147 93.76 High High
INFLAMMATION 50 91.20 High High
Disease 33 88.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of EGFR associated with targeted disruption and qutenza
1) Confidence 0.68 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20660715 Disease Relevance 0.82 Pain Relevance 0.85
Increased EGFR tyrosine phosphorylation in the rectal mucosa of patients with UC has been reported [21].
Positive_regulation (Increased) of Phosphorylation (phosphorylation) of EGFR associated with inflammatory bowel disease
2) Confidence 0.61 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.07 Pain Relevance 0.32
A separate study showed that the TKI gefitinib completely inhibited EGF-induced cell proliferation as well as EGFR autophosphorylation and phosphorylation of MAPK in pancreatic cancer cell lines (Li et al 2004).
Positive_regulation (induced) of Phosphorylation (autophosphorylation) of EGFR associated with pancreatic cancer
3) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.90 Pain Relevance 0
In vitro, ipriflavone inhibited the proliferation and DNA synthesis of MDA-231 cells and blocked the ligand-induced phosphorylation of Tyr(845) of the EGFR.
Positive_regulation (ligand-induced) of Phosphorylation (phosphorylation) of EGFR
4) Confidence 0.49 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12115517 Disease Relevance 1.25 Pain Relevance 0
Impact of EGFR or EGFRvIII on Survival
Positive_regulation (on) of Phosphorylation (Impact) of EGFR
5) Confidence 0.46 Published 2005 Journal J Transl Med Section Body Doc Link PMC1298339 Disease Relevance 0.86 Pain Relevance 0
Mice treated with PGE 2 had increased expression of Cox-2 and the EGFR-ligand, AR, leading to increased phosphorylation and activation of EGFR, indicating positive feedback.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of EGFR
6) Confidence 0.41 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.14 Pain Relevance 0.09
These authors reported that the autophosphorylation of Y350 in the EGFR does not occur after LPA exposure, suggesting that c-Src is the principal tyrosine kinase in this instance and not the EGFR's intrinsic tyrosine kinase.
Neg (not) Positive_regulation (occur) of Phosphorylation (autophosphorylation) of EGFR
7) Confidence 0.38 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.16
ERK activation and EGFR phosphorylation via each of these receptors was inhibited by prior exposure to the EGFR kinase inhibitor, AG1478.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of EGFR
8) Confidence 0.38 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.09
In the presence of the EGFR, ligand activation of LPA and ET-1 receptors did not increase EGFR phosphorylation even though both the LPA and ET-1 receptors stimulated ERK activity by 10-fold over basal [27].
Neg (not) Positive_regulation (increase) of Phosphorylation (phosphorylation) of EGFR
9) Confidence 0.38 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.13 Pain Relevance 0.17
Tyrosine phosphorylation of the EGFR is apparent after agonist stimulation of the ?
Positive_regulation (apparent) of Phosphorylation (phosphorylation) of EGFR associated with agonist
10) Confidence 0.38 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.10
HEK-293 cells endogenously express the EGFR, and EGF produces robust ERK activation concomitant with EGFR tyrosine phosphorylation.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of EGFR
11) Confidence 0.38 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.16 Pain Relevance 0.14
We have shown activation of the EP2 and FP receptors can lead to phosphorylation of ERK1/2 via the activation of c-Src and transphosphorylation of the epidermal growth factor receptor (EGFR) in Ishikawa cells and endometrial adenocarcinoma explants ex vivo [7,18].
Positive_regulation (activation) of Phosphorylation (transphosphorylation) of EGFR associated with endometriosis (extended)
12) Confidence 0.28 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.45 Pain Relevance 0.13
We have shown activation of the EP2 and FP receptors can lead to phosphorylation of ERK1/2 via the activation of c-Src and transphosphorylation of the epidermal growth factor receptor (EGFR) in Ishikawa cells and endometrial adenocarcinoma explants ex vivo [7,18].
Positive_regulation (activation) of Phosphorylation (transphosphorylation) of EGFR associated with endometriosis (extended)
13) Confidence 0.20 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.45 Pain Relevance 0.13

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