INT103918

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 10.12
Pain Relevance 5.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Anatomy Link Frequency
spinal cord 2
MDA-MB-468 2
dorsal horn 1
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 24 100.00 Very High Very High Very High
Neuropathic pain 44 99.80 Very High Very High Very High
Pain 320 99.40 Very High Very High Very High
Spinal cord 44 98.84 Very High Very High Very High
Dorsal horn 6 98.68 Very High Very High Very High
antagonist 26 98.44 Very High Very High Very High
agonist 3 95.52 Very High Very High Very High
B1 receptor 36 88.36 High High
Neuronal nitric oxide synthase 3 84.56 Quite High
Analgesic 101 69.20 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 60 99.80 Very High Very High Very High
Pain 323 99.40 Very High Very High Very High
Breast Cancer 303 99.16 Very High Very High Very High
Cancer 533 98.88 Very High Very High Very High
Nervous System Injury 7 98.88 Very High Very High Very High
Apoptosis 1 96.24 Very High Very High Very High
Metastasis 132 95.44 Very High Very High Very High
Disease 11 93.60 High High
Basal And Squamous Cell Skin Cancer 14 78.00 Quite High
Psoriasis 14 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, ipriflavone inhibited the proliferation and DNA synthesis of MDA-231 cells and blocked the ligand-induced phosphorylation of Tyr(845) of the EGFR.
Phosphorylation (phosphorylation) of Tyr
1) Confidence 0.47 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12115517 Disease Relevance 1.24 Pain Relevance 0
The level of phosphorylated Tyr-1472 NR2B in the vehicle control in cancer-induced pain mice was 210% higher than the normal control samples (p < 0.05) (Figure 3A, B); however, the repeated administration of Z-360 (100 mg/kg) once a day from day 7 to 14 after transplantation suppressed phosphorylation by 62.5% compared with the vehicle control (p < 0.05) (Figure 3A, B).


Phosphorylation (phosphorylated) of Tyr-1472 associated with pain and cancer
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.18 Pain Relevance 0.71
As it has been reported that ephrin B2 induces phosphorylation of Tyr-1472 residues [14], we next investigated whether Tyr-1472 phosphorylation of NR2B was enhanced in the spinal cord of the mouse model of cancer-induced pain.
Phosphorylation (phosphorylation) of Tyr-1472 in spinal cord associated with pain, cancer and spinal cord
3) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.05 Pain Relevance 0.66
As it has been reported that ephrin B2 induces phosphorylation of Tyr-1472 residues [14], we next investigated whether Tyr-1472 phosphorylation of NR2B was enhanced in the spinal cord of the mouse model of cancer-induced pain.
Phosphorylation (phosphorylation) of Tyr-1472 in spinal cord associated with pain, cancer and spinal cord
4) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.10 Pain Relevance 0.71
Several tyrosine residues in the C-terminal cytoplasmic region of NR2B have been shown to be phosphorylated by Src family tyrosine kinases in vitro [28], with Tyr-1472 being the major phosphorylation site.
Phosphorylation (phosphorylation) of Tyr-1472
5) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.99 Pain Relevance 0.66
The present study demonstrates that Tyr1472 phosphorylation of NR2B subunits by Fyn kinase may have dual roles in the retention of NMDA receptors in the postsynaptic density and in activation of nitric oxide synthase, and suggests that PGE2 is involved in the maintenance of neuropathic pain via the EP1 subtype.
Phosphorylation (phosphorylation) of Tyr1472 associated with nmda receptor and neuropathic pain
6) Confidence 0.02 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.63 Pain Relevance 1.05
Neuropathic pain and NR2B phosphorylation at Tyr1472 were attenuated by the NR2B-selective antagonist CP-101,606 and disappeared in mice lacking Fyn kinase, a Src-family tyrosine kinase.
Phosphorylation (phosphorylation) of Tyr1472 associated with antagonist and neuropathic pain
7) Confidence 0.01 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.76 Pain Relevance 1.11
Wild-type, NR2A-deficient, and NR2D-deficient mice developed neuropathic pain; in addition, phosphorylation of NR2B subunits of NMDA receptors at Tyr1472 was observed in the superficial dorsal horn of the spinal cord 1 week after nerve injury.
Phosphorylation (phosphorylation) of Tyr1472 in dorsal horn associated with nervous system injury, nmda receptor, dorsal horn, neuropathic pain and spinal cord
8) Confidence 0.01 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.75 Pain Relevance 1.07
Furthermore, our signaling studies revealed that EGF induced simultaneous EGF receptor phosphorylation at Tyr1173 and HER2 phosphorylation at Tyr1248 in S100A7-downregulated cell lines as compared to the vector-transfected controls.
Phosphorylation (phosphorylation) of Tyr1248
9) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2254193 Disease Relevance 0.51 Pain Relevance 0
In our study, phosphorylations of EGFR Tyr1173 and HER2 Tyr1248 (Figure 3A), EGFR Tyr1173 (Figure 3B), and Tyr1068 (data not shown) were reduced in S100A7-downregulated cells as compared to empty vector-transfected cell lines following treatment with increasing concentrations of EGF.
Phosphorylation (phosphorylations) of Tyr1173
10) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.17 Pain Relevance 0
Furthermore, our signaling studies revealed that EGF induced simultaneous EGF receptor phosphorylation at Tyr1173 and HER2 phosphorylation at Tyr1248 in S100A7-downregulated cell lines as compared to the vector-transfected controls.
Phosphorylation (phosphorylation) of Tyr1173
11) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2254193 Disease Relevance 0.51 Pain Relevance 0
In our study, phosphorylations of EGFR Tyr1173 and HER2 Tyr1248 (Figure 3A), EGFR Tyr1173 (Figure 3B), and Tyr1068 (data not shown) were reduced in S100A7-downregulated cells as compared to empty vector-transfected cell lines following treatment with increasing concentrations of EGF.
Phosphorylation (phosphorylations) of Tyr1173
12) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.16 Pain Relevance 0
In our study, phosphorylations of EGFR Tyr1173 and HER2 Tyr1248 (Figure 3A), EGFR Tyr1173 (Figure 3B), and Tyr1068 (data not shown) were reduced in S100A7-downregulated cells as compared to empty vector-transfected cell lines following treatment with increasing concentrations of EGF.
Phosphorylation (phosphorylations) of Tyr1248
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.16 Pain Relevance 0
We noted a decrease in EGFR/HER2 phosphorylation at Tyr1068, Tyr1173, and Tyr1248 (HER2) sites in S100A7-downregulated MDA-MB-468 cells as compared to empty vector-transfected control cells upon EGF stimulation.
Phosphorylation (phosphorylation) of Tyr1248 in MDA-MB-468
14) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.45 Pain Relevance 0
We noted a decrease in EGFR/HER2 phosphorylation at Tyr1068, Tyr1173, and Tyr1248 (HER2) sites in S100A7-downregulated MDA-MB-468 cells as compared to empty vector-transfected control cells upon EGF stimulation.
Phosphorylation (phosphorylation) of Tyr1173 in MDA-MB-468
15) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.45 Pain Relevance 0

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