INT103919

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.01
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 8 99.80 Very High Very High Very High
antagonist 2 99.08 Very High Very High Very High
Spinal cord 4 97.84 Very High Very High Very High
Dorsal horn 2 97.08 Very High Very High Very High
nMDA receptor 4 94.88 High High
Neuronal nitric oxide synthase 1 85.84 High High
Pain 4 79.20 Quite High
agonist 1 47.52 Quite Low
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.80 Very High Very High Very High
Nervous System Injury 1 98.88 Very High Very High Very High
Apoptosis 1 96.24 Very High Very High Very High
Cancer 5 94.24 High High
Metastasis 6 85.40 High High
Pain 1 79.20 Quite High
Breast Cancer 2 77.56 Quite High
Osteoporosis 2 69.48 Quite High
Hypercalcemia 1 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, ipriflavone inhibited the proliferation and DNA synthesis of MDA-231 cells and blocked the ligand-induced phosphorylation of Tyr(845) of the EGFR.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of Tyr
1) Confidence 0.32 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12115517 Disease Relevance 1.25 Pain Relevance 0
Neuropathic pain and NR2B phosphorylation at Tyr1472 were attenuated by the NR2B-selective antagonist CP-101,606 and disappeared in mice lacking Fyn kinase, a Src-family tyrosine kinase.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of Tyr1472 associated with antagonist and neuropathic pain
2) Confidence 0.01 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.76 Pain Relevance 1.12

General Comments

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