INT103924

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2011
Negated 7
Speculated 7
Reported most in Body
Documents 359
Total Number 366
Disease Relevance 158.94
Pain Relevance 60.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
muscle 10
lung 7
endothelial cell 5
neuronal 5
skeletal muscle 4
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1338 100.00 Very High Very High Very High
Nerve growth factor 99 100.00 Very High Very High Very High
Inflammation 2541 99.98 Very High Very High Very High
Arthritis 437 99.98 Very High Very High Very High
Morphine 1657 99.96 Very High Very High Very High
Inflammatory response 385 99.90 Very High Very High Very High
GABA receptor 16 99.90 Very High Very High Very High
cytokine 987 99.84 Very High Very High Very High
Cannabinoid receptor 43 99.82 Very High Very High Very High
nMDA receptor 128 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 3442 100.00 Very High Very High Very High
Apoptosis 2468 100.00 Very High Very High Very High
Stress 1841 100.00 Very High Very High Very High
INFLAMMATION 2843 99.98 Very High Very High Very High
Shock 996 99.98 Very High Very High Very High
Arthritis 471 99.98 Very High Very High Very High
Infection 418 99.96 Very High Very High Very High
Erythrocytosis 105 99.92 Very High Very High Very High
Nephrotoxicity 24 99.88 Very High Very High Very High
Prostate Cancer 53 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mitochondrial potential and Akt (threonine-serine protein kinase B) activation were also examined.
Spec (examined) Positive_regulation (activation) of Akt
1) Confidence 0.69 Published 2010 Journal Neuroscience Section Abstract Doc Link 20038443 Disease Relevance 0.63 Pain Relevance 0.65
Moreover, activation of Akt in response to insulin stimulation has been shown to involve the phosphorylation of Ser473 and Thr308 residues (Toker and Newton 2000).
Positive_regulation (activation) of Akt
2) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.26 Pain Relevance 0
Reduced Akt activation was also associated with inhibition of C2C12 myoblast differentiation (Sumitani et al. 2002).
Positive_regulation (activation) of Akt in myoblast
3) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.18 Pain Relevance 0
Both LAs suppressed Akt activation, which correlated with their effects on apoptosis.
Positive_regulation (activation) of Akt
4) Confidence 0.68 Published 2010 Journal Acta Pharmacol. Sin. Section Body Doc Link 20228829 Disease Relevance 0.06 Pain Relevance 0
Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors.
Positive_regulation (activation) of AKT in striatum associated with opioid receptor
5) Confidence 0.68 Published 2010 Journal Addict Biol Section Title Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.30
We also examined the levels of intracellular reactive oxygen species (ROS) and activation of PI3K/Akt signaling pathway.
Spec (examined) Positive_regulation (activation) of Akt
6) Confidence 0.68 Published 2010 Journal Neurotoxicology Section Body Doc Link 19879292 Disease Relevance 0.17 Pain Relevance 0
In addition, LA treatment increased the levels of phospho-Akt and phospho-GSK3beta and attenuated bupivacaine decreased the levels of ROS.
Positive_regulation (increased) of Akt
7) Confidence 0.68 Published 2010 Journal Neurotoxicology Section Body Doc Link 19879292 Disease Relevance 0.13 Pain Relevance 0
Therefore, it is possible that overexpression of AXL and GAS6 is a main cause for the activation of the PI3K-Akt pathway in endometriosis.
Positive_regulation (activation) of Akt associated with endometriosis
8) Confidence 0.67 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.78 Pain Relevance 0.24
Taken together, these results implicate that preassembly of the Pol II preinitiation complex, sustained activation of PI3K/Akt/NF-kappaB signaling, and dynamic p300 association at the promoters sequentially is one of the mechanisms of induction of the late phase genes during NGF-induced neuronal differentiation.
Positive_regulation (activation) of Akt in neuronal associated with nerve growth factor
9) Confidence 0.67 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399742 Disease Relevance 0.05 Pain Relevance 0.48
Other contributing effects of morphine include activation of the survival signal PKB/Akt, inhibition of apoptosis, and promotion of cell cycle progression by increasing cyclin D1.
Positive_regulation (activation) of PKB/Akt associated with apoptosis and morphine
10) Confidence 0.67 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154060 Disease Relevance 0.59 Pain Relevance 0.58
In Reg2-/- mice, liver regeneration was markedly impaired, with 29% mortality and delay of the S-phase and the activation of ERK1/2 and AKT.
Positive_regulation (activation) of AKT in liver
11) Confidence 0.67 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.53 Pain Relevance 0.07
The inhibition of Akt/MAPK activation with Akt-deficient mice and pharmacological inhibitors reduced the high-tidal-volume-induced microvascular permeability, lung fibrosis, and chemokine production.
Positive_regulation (activation) of Akt/MAPK in lung associated with chemokine, fibrosis and pulmonary fibrosis
12) Confidence 0.65 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.24 Pain Relevance 0.09
Inhibition of Akt/MAPK activation with Akt-deficient mice and pharmacological inhibitors
Positive_regulation (activation) of Akt/MAPK
13) Confidence 0.65 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.22 Pain Relevance 0.08
RESULTS: The epidermal growth factor receptor was expressed in all cell lines tested, and treatment with erlotinib did inhibit the activation of the MEK/extracellular signal-regulated kinase and AKT signaling pathways.
Positive_regulation (activation) of AKT
14) Confidence 0.61 Published 2009 Journal Clin. Cancer Res. Section Body Doc Link 19447871 Disease Relevance 0.09 Pain Relevance 0
Two weeks after axotomy, the number of p-Akt-positive NPs was only slightly reduced, but p-Akt immunofluorescence intensity was strongly increased.
Positive_regulation (increased) of Akt
15) Confidence 0.61 Published 2009 Journal Neurosignals Section Abstract Doc Link 19346757 Disease Relevance 0.68 Pain Relevance 0.59
Additionally, PA contributes to the activation of Akt/phosphatidylinositol 3-kinase (PI3K) signaling by stimulating PI4P5-kinase [24].
Positive_regulation (activation) of Akt
16) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.13 Pain Relevance 0.10
Therefore, we examined the effect of TGZ on the activation of Akt by Western blot analysis.
Spec (examined) Positive_regulation (activation) of Akt
17) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.48 Pain Relevance 0
Furthermore, a number of publications showed that activation of PLC-PI3K-AKT signaling led to apoptosis arrest in neurodegeneration [31] and atherosclerosis [32].
Positive_regulation (activation) of AKT associated with increased venous pressure under development and apoptosis
18) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.67 Pain Relevance 0
Systemic administration of VLPs activated Akt-1 and upregulated Hsp/c70 in vivo.
Positive_regulation (activated) of Akt
19) Confidence 0.55 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2515219 Disease Relevance 1.39 Pain Relevance 0.05
This is most likely because of the time required for the induction of the Akt survival pathway and chaperone upregulation.
Positive_regulation (induction) of Akt
20) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.47 Pain Relevance 0

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