INT103925

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 15.19
Pain Relevance 7.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
poly 4
liver 2
cleavage 2
spleen 2
myoblast 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 185 100.00 Very High Very High Very High
cytokine 59 100.00 Very High Very High Very High
Inflammatory response 15 100.00 Very High Very High Very High
opioid receptor 336 98.72 Very High Very High Very High
Cannabinoid 114 97.32 Very High Very High Very High
Analgesic 76 97.20 Very High Very High Very High
qutenza 9 96.64 Very High Very High Very High
Morphine 308 96.40 Very High Very High Very High
tolerance 118 95.64 Very High Very High Very High
cINOD 7 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 196 100.00 Very High Very High Very High
Targeted Disruption 59 99.70 Very High Very High Very High
Insulin Resistance 32 99.40 Very High Very High Very High
Cancer 418 99.16 Very High Very High Very High
Apoptosis 234 98.72 Very High Very High Very High
Disorder Of Lipid Metabolism 146 98.68 Very High Very High Very High
Sprains And Strains 19 98.62 Very High Very High Very High
Death 100 98.08 Very High Very High Very High
Sepsis 7 97.04 Very High Very High Very High
Breast Cancer 72 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced Akt activation was also associated with inhibition of C2C12 myoblast differentiation (Sumitani et al. 2002).
Negative_regulation (Reduced) of Positive_regulation (activation) of Akt in myoblast
1) Confidence 0.58 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.18 Pain Relevance 0
Inhibition of Akt/MAPK activation with Akt-deficient mice and pharmacological inhibitors
Negative_regulation (Inhibition) of Positive_regulation (activation) of Akt/MAPK
2) Confidence 0.55 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.22 Pain Relevance 0.08
Notably, naltrindole reduced Akt activation, suggesting that it can act as a cell permeable Akt inhibitor in vivo [54].
Negative_regulation (reduced) of Positive_regulation (activation) of Akt
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.21
Caspase-9 and caspase 3, which are downregulated upon PKB/Akt activation, fail to activate pathways leading to apoptosis [19].
Negative_regulation (downregulated) of Positive_regulation (activation) of PKB/Akt associated with apoptosis
4) Confidence 0.42 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 1.13 Pain Relevance 0.29
In Reg2-/- mice, liver regeneration was markedly impaired, with 29% mortality and delay of the S-phase and the activation of ERK1/2 and AKT.
Negative_regulation (impaired) of Positive_regulation (activation) of AKT in liver
5) Confidence 0.42 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.55 Pain Relevance 0.08
The inhibition of Akt/MAPK activation with Akt-deficient mice and pharmacological inhibitors reduced the high-tidal-volume-induced microvascular permeability, lung fibrosis, and chemokine production.
Negative_regulation (inhibition) of Positive_regulation (activation) of Akt/MAPK in lung associated with chemokine, fibrosis and pulmonary fibrosis
6) Confidence 0.40 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.24 Pain Relevance 0.09
RESULTS: The epidermal growth factor receptor was expressed in all cell lines tested, and treatment with erlotinib did inhibit the activation of the MEK/extracellular signal-regulated kinase and AKT signaling pathways.
Negative_regulation (inhibit) of Positive_regulation (activation) of AKT
7) Confidence 0.37 Published 2009 Journal Clin. Cancer Res. Section Body Doc Link 19447871 Disease Relevance 0.09 Pain Relevance 0
LPS resulted in a time-dependent activation of Akt, which was blocked by treatment with rolipram or PI3K and Akt inhibitors, and PI3K and Akt inhibitors also enhanced apoptosis and promoted neutrophil clearance.
Negative_regulation (blocked) of Positive_regulation (activation) of Akt in neutrophil associated with apoptosis
8) Confidence 0.35 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.74 Pain Relevance 0.31
We found that myostatin inhibition resulted in increased activation of Akt and NFAT3, while myostatin overexpression caused decreased activation of Akt and NFAT3.
Negative_regulation (decreased) of Positive_regulation (activation) of Akt
9) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.15 Pain Relevance 0
Because insulin resistance is characterized by a marked reduction in insulin-stimulated PI3K-mediated activation of Akt, we asked whether MES could increase Akt phosphorylation and ameliorate insulin resistance.
Negative_regulation (reduction) of Positive_regulation (activation) of Akt associated with insulin resistance
10) Confidence 0.32 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2603588 Disease Relevance 0.88 Pain Relevance 0
These events coincided with a decrease in the activation of Akt via pThr308, the appearance of active pThr286 CaMKII and subsequent reduction of nNOS activity via an increase of pSer847 and dephosphorylation of pSer1417.
Negative_regulation (decrease) of Positive_regulation (activation) of Akt
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.05
The activation of the Akt-nNOS pathway was also reduced by the binding of these proteins to the MOR-HINT1 complex where they remained inactive.
Negative_regulation (reduced) of Positive_regulation (activation) of Akt associated with opioid receptor
12) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.10 Pain Relevance 1.09
Notably, early Akt-nNOS activation was immediately followed by a decrease in its strength prior to the 30 min interval, the time when the peak analgesic effect of morphine was reached.
Negative_regulation (decrease) of Positive_regulation (activation) of Akt associated with analgesic and morphine
13) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.09 Pain Relevance 0.94
Myostatin inhibition caused increased activation of Akt and NFAT3 (activated by dephosphorylation) compared to LacZ control, while myostatin overexpression caused decreased activation of Akt and NFAT3 compared to LacZ control (Fig. 7A, B).
Negative_regulation (decreased) of Positive_regulation (activation) of Akt
14) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.16 Pain Relevance 0
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Negative_regulation (reduced) of Positive_regulation (activation) of AKT
15) Confidence 0.24 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.98 Pain Relevance 0.04
These results demonstrate that BV-treatment of familial mutant hSOD1 transgenic mice caused a reduction in pro-inflammatory cytokines and an increase in phospho-Akt and ERK, which may inhibit motor neuronal cell death by preventing neuroninflammation and consequently delay disease onset.


Negative_regulation (reduction) of Positive_regulation (increase) of Akt in neuronal associated with targeted disruption, inflammation, disease, death and cytokine
16) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.78 Pain Relevance 0.40
Furthermore, HDL inhibit thrombin-induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS (Viswambharan et al 2004).
Negative_regulation (inhibition) of Positive_regulation (activation) of Akt associated with disorder of lipid metabolism
17) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.18 Pain Relevance 0
We observed a decrease in Akt activation in THC-treated MMTV-neu tumors (Fig. 5B) as well as diminished levels of phosphorylated S6 ribosomal protein [a read-out for activation of the Akt/mammalian target of rapamycin (mTOR) pathway [12]] (Fig. 5C).
Negative_regulation (decrease) of Positive_regulation (activation) of Akt associated with cancer
18) Confidence 0.19 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.58 Pain Relevance 0.20
Indeed, while wortmannin (WT) inhibited both the activation of Akt (Fig. 4B, top) and SphK1 (Fig. 4B, bottom) induced by DHT, the SphK1 inhibitor SKI-2 did not impact Akt phosphorylation (Fig. 4B, top).
Negative_regulation (inhibited) of Positive_regulation (activation) of Akt
19) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0.03
C-KIT autophosphorylation, activation of mitogen activated protein (MAP) kinase and activation of Akt were all inhibited in a c-KIT expressing cell line.
Negative_regulation (inhibited) of Positive_regulation (activation) of Akt
20) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.75 Pain Relevance 0

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