INT103959

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2006
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.47
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ATP1A2) plasma membrane (ATP1A2) locomotion (ATP1A2)
transmembrane transport (ATP1A2) cytoplasm (ATP1A2)
ATP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 81 99.76 Very High Very High Very High
Calcium channel 10 95.72 Very High Very High Very High
Central nervous system 1 94.32 High High
Glutamate 4 85.92 High High
headache 7 77.76 Quite High
potassium channel 7 55.76 Quite High
Action potential 2 36.00 Quite Low
Neuronal excitability 1 32.88 Quite Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 34 99.76 Very High Very High Very High
Headache 65 98.84 Very High Very High Very High
Intellectual Impairment 1 90.24 High High
Hemiplegia 4 88.96 High High
Brain Disease 1 87.04 High High
Neurological Disease 6 84.36 Quite High
Channelopathies 2 81.40 Quite High
Ataxia 1 79.52 Quite High
Convulsion 1 78.88 Quite High
Migraine Without Aura 20 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ATP1A2 ion channel gene, codes for the alpha2 subunit of the Na+, K+ ion ATPase pump.
Gene_expression (pump) of ATP1A2
1) Confidence 0.67 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1236929 Disease Relevance 1.30 Pain Relevance 1.03
Although no mutations were detected in the FHM1 CACNA1A and FHM2 ATP1A2 genes in sporadic AHC patients, a mutation was found in the FHM2 ATP1A2 gene in a family with AHC.
Neg (no) Gene_expression (detected) of ATP1A2
2) Confidence 0.65 Published 2006 Journal Neuropediatrics Section Abstract Doc Link 17236110 Disease Relevance 0.94 Pain Relevance 0.42
Mutation analysis among eight affected individuals from a single large, highly penetrant FHM family was negative in ATP1A4 and ATP1A2 although multiple polymorphisms were identified.
Neg (negative) Gene_expression (negative) of ATP1A2 associated with migraine
3) Confidence 0.60 Published 2002 Journal Gene Section Abstract Doc Link 12119109 Disease Relevance 0.23 Pain Relevance 0.23

General Comments

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