INT103960

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Context Info
Confidence 0.73
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.05
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ATP1A4) transmembrane transport (ATP1A4)
Anatomy Link Frequency
muscle 1
ATP1A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 39 100.00 Very High Very High Very High
Migraine 7 99.76 Very High Very High Very High
agonist 174 99.58 Very High Very High Very High
beta blocker 3 72.80 Quite High
lidocaine 3 62.32 Quite High
fibrosis 6 40.44 Quite Low
corticosteroid 3 33.76 Quite Low
Catecholamine 12 31.88 Quite Low
Dopamine 3 20.24 Low Low
Inflammation 63 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 12 99.78 Very High Very High Very High
Migraine With Aura 7 99.76 Very High Very High Very High
Pressure And Volume Under Development 117 99.26 Very High Very High Very High
Adult Respiratory Distress Syndrome 276 98.34 Very High Very High Very High
Lung Injury 27 91.40 High High
Injury 30 87.40 High High
Disease 2 51.44 Quite High
Cystic Fibrosis 3 40.44 Quite Low
Dystonia 1 40.40 Quite Low
Parkinson's Disease 1 39.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression analysis of the ATP1A4 gene revealed a new major approximately 7.5 kb transcript in human skeletal muscle, with expression also shown in mouse muscle.
Gene_expression (Expression) of ATP1A4 in muscle
1) Confidence 0.73 Published 2002 Journal Gene Section Abstract Doc Link 12119109 Disease Relevance 0.23 Pain Relevance 0.23
Mutation analysis among eight affected individuals from a single large, highly penetrant FHM family was negative in ATP1A4 and ATP1A2 although multiple polymorphisms were identified.
Neg (negative) Gene_expression (negative) of ATP1A4 associated with migraine
2) Confidence 0.63 Published 2002 Journal Gene Section Abstract Doc Link 12119109 Disease Relevance 0.23 Pain Relevance 0.23
The examples cited above provide some indication to the diversity of Na,K-ATPase isoform expression.
Gene_expression (expression) of Na,K-ATPase isoform
3) Confidence 0.32 Published 2007 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 18044013 Disease Relevance 0.05 Pain Relevance 0
In contrast, after long-term stimulation by beta agonists, there is increased expression of apical channels and the Na,K-ATPase pump, and there is stimulation of epidermal growth factor, leading to increased normal cell growth that may also enhance edema clearance.
Gene_expression (expression) of Na,K-ATPase associated with pressure and volume under development and agonist
4) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 0.24 Pain Relevance 0.28
Beta-2 adrenergic agonists modulate the expression of the epithelial apical sodium channel as well as the expression of the Na,K-ATPase pump.
Gene_expression (expression) of Na,K-ATPase associated with sodium channel and agonist
5) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 1.19 Pain Relevance 0.36
Hypoxia, a common feature of ALI/ARDS, may in addition contribute to impaired edema clearance because hypoxia decreases expression of subunits of the sodium channel and of the Na,K-ATPase pump [24].
Gene_expression (expression) of Na,K-ATPase associated with pressure and volume under development, hypoxia, sodium channel and adult respiratory distress syndrome
6) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 1.11 Pain Relevance 0.24

General Comments

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