INT103966

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.95
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
endometrium 4
hepatocytes 2
ducts 2
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 99.98 Very High Very High Very High
endometriosis 92 98.40 Very High Very High Very High
diclofenac 11 97.96 Very High Very High Very High
opioid receptor 1 92.96 High High
metalloproteinase 1 92.24 High High
Inflammation 9 88.76 High High
narcan 2 86.64 High High
Inflammatory response 1 80.16 Quite High
lidocaine 2 78.64 Quite High
opiate 2 70.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 200 100.00 Very High Very High Very High
Death 46 99.92 Very High Very High Very High
Endometriosis 96 98.40 Very High Very High Very High
Injury 7 97.00 Very High Very High Very High
Toxicity 1 91.12 High High
Cancer 106 89.76 High High
Malignant Neoplastic Disease 10 89.04 High High
INFLAMMATION 11 88.76 High High
Hypoxia 2 83.44 Quite High
Endometrial Cancer 5 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with these results, recent publications [3,34,35] also reported the absence of apoptotic cells and the increase of Bcl-2 and the reduction of Bax expression in eutopic endometrium from women with endometriosis, although Béliard et al. (2004) [4] were unable to find these differences between patients with endometriosis and normal women.
Negative_regulation (reduction) of Gene_expression (expression) of Bax in endometrium associated with endometriosis and apoptosis
1) Confidence 0.56 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 1.29 Pain Relevance 0.22
Inasmuch as Bcl-2 suppresses while Bax accelerates apoptosis, treatment of cells with morphine reduced the expression of Bax and enhanced the expression of Bcl-2.
Negative_regulation (reduced) of Gene_expression (expression) of Bax associated with apoptosis and morphine
2) Confidence 0.51 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12927789 Disease Relevance 0.86 Pain Relevance 0.86
Inhibition of Bax protein expression by using siRNA significantly protected HC-04 from diclofenac-induced cell injury.
Negative_regulation (Inhibition) of Gene_expression (expression) of Bax protein associated with injury and diclofenac
3) Confidence 0.51 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18191430 Disease Relevance 0.87 Pain Relevance 0.49
In pancreatic ductal adenocarcinoma and ampullary cancer, bcl-2 was not detected compared with expression seen in normal acini (p < 0.01), minor (p < 0.001) and major ducts (p < 0.01), bax expression was reduced with respect to minor ducts (p < 0.01) but no different from normal acini or major ducts. bak and bcl-x were more strongly expressed in malignant epithelia compared with acini and major ducts but reduced when compared with minor ducts (p < 0.01).
Negative_regulation (reduced) of Gene_expression (expression) of bax in ducts
4) Confidence 0.42 Published 2001 Journal Pancreatology Section Body Doc Link 12120204 Disease Relevance 0.07 Pain Relevance 0
Concomitantly to the absence of apoptosis in those endometria, the pro-apoptotic gene bax mRNA abundance was unchanged during the menstrual cycle, at difference at the increase exhibited in normal endometrium, suggesting that the reduction of bax expression may be a mechanism that could explain the decreased incidence of apoptosis in endometriosis.
Negative_regulation (reduction) of Gene_expression (expression) of bax in endometrium associated with endometriosis and apoptosis
5) Confidence 0.40 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 1.27 Pain Relevance 0.22
Freshly isolated hepatocytes perfused into the RFB showed a progressive increase of MEGX while a loss in Bax expression was paralleled by an increase in Bcl-2 expression, in comparison to starting hepatocytes.
Negative_regulation (loss) of Gene_expression (expression) of Bax in hepatocytes associated with apoptosis
6) Confidence 0.40 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12653348 Disease Relevance 0.64 Pain Relevance 0.08
Positive Bax expression was seen in 60.9% (14 patients).
Negative_regulation (Positive) of Gene_expression (expression) of Bax
7) Confidence 0.31 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.74 Pain Relevance 0
This inhibition is associated with increased levels of the anti-apoptotic factors Bcl-xl and Bcl-2 as well as with decreased levels of Bax.
Negative_regulation (decreased) of Gene_expression (levels) of Bax associated with apoptosis
8) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.31 Pain Relevance 0.27
Immunoblot analysis demonstrated that expression of GAAPs did not interfere with Bax expression levels (Figure 5B, right panel).
Neg (not) Negative_regulation (interfere) of Gene_expression (expression) of Bax
9) Confidence 0.09 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.92 Pain Relevance 0

General Comments

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