INT103967

Context Info Confidence 0.42 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 8 Total Number 9 Disease Relevance 7.02 Pain Relevance 1.54

cytosol (BAK1) mitochondrion (BAK1) aging (BAK1) endoplasmic reticulum (BAK1) intracellular (BAK1)

Anatomy Link Frequency dorsal horn 2 ducts 2 BAK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Dismenorea 2 100.00 Neuropathic pain 2 99.98 Glutamate 2 98.96 Dorsal horn 1 98.56 Inflammation 43 97.28 Sciatic nerve 1 96.84 cINOD 7 96.32 Analgesic 1 96.24 Hyperalgesia 3 89.28 Spinal cord 3 88.60

Disease Link Frequency Relevance Heat Apoptosis 144 100.00 Dysmenorrhea 2 100.00 Neuropathic Pain 2 99.98 Carcinoma 94 99.84 Disorder Of Lipid Metabolism 3 99.56 Prostate Cancer 6 97.56 INFLAMMATION 56 97.28 Death 18 95.84 Injury 10 95.44 Colon Cancer 6 92.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In pancreatic ductal adenocarcinoma and ampullary cancer, bcl-2 was not detected compared with expression seen in normal acini (p < 0.01), minor (p < 0.001) and major ducts (p < 0.01), bax expression was reduced with respect to minor ducts (p < 0.01) but no different from normal acini or major ducts. bak and bcl-x were more strongly expressed in malignant epithelia compared with acini and major ducts but reduced when compared with minor ducts (p < 0.01).

Negative_regulation (reduced) of Gene_expression (expressed) of bak in ducts

1) Confidence 0.42 Published 2001 Journal Pancreatology Section Body Doc Link 12120204 Disease Relevance 0.07 Pain Relevance 0

Another prospective explanation cited by the authors included the potential for BAK and the PG analogues forming an emulsion, thus reducing the BAK exposure.

Negative_regulation (reducing) of Gene_expression (exposure) of BAK

2) Confidence 0.37 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2921296 Disease Relevance 0.61 Pain Relevance 0.06

Another prospective explanation cited by the authors included the potential for BAK and the PG analogues forming an emulsion, thus reducing the BAK exposure.

Negative_regulation (reducing) of Gene_expression (exposure) of BAK

3) Confidence 0.37 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2921296 Disease Relevance 0.61 Pain Relevance 0.06

The molecular mechanisms that mediate the pro-apoptotic effect of Mcl-1 downregulation in HCC cells remain elusive and are subject to further studies.

Negative_regulation (downregulation) of Gene_expression (effect) of pro-apoptotic associated with carcinoma and apoptosis

4) Confidence 0.20 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.98 Pain Relevance 0

In conclusion, the ability of ropivacaine to induce antiproliferative responses and to suppress the expression of the anti-apoptotic protein clusterin/apolipoprotein J, combined with previously reported anti-inflammatory activity and analgesic property of the drug, suggests that ropivacaine may have potential utility in the local treatment of tumors.

Negative_regulation (suppress) of Gene_expression (expression) of anti-apoptotic protein associated with inflammation, cancer, analgesic, apoptosis and disorder of lipid metabolism

5) Confidence 0.05 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.98 Pain Relevance 0.14

Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, induced apoptosis and strongly reduced the expression of an anti-apoptotic protein, survivin, in both protein and mRNA levels in HCT-116 cells.

Negative_regulation (reduced) of Gene_expression (expression) of anti-apoptotic protein associated with apoptosis

6) Confidence 0.03 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17270149 Disease Relevance 0.46 Pain Relevance 0.28

Treatment with amygdalin increased expression of Bax, a pro-apoptotic protein, decreased expression of Bcl-2, an anti-apoptotic protein, and increased caspase-3 enzyme activity in DU145 and LNCaP prostate cancer cells.

Negative_regulation (decreased) of Gene_expression (expression) of anti-apoptotic protein associated with prostate cancer and apoptosis

7) Confidence 0.03 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.68 Pain Relevance 0.07

Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early over-expression of pro-apoptotic genes and morphological changes in dorsal horn lamina II.

Negative_regulation (prevents) of Gene_expression (over-expression) of pro-apoptotic in dorsal horn associated with glutamate, dorsal horn, neuropathic pain and apoptosis

8) Confidence 0.00 Published 2004 Journal Neuropharmacology Section Title Doc Link 14975670 Disease Relevance 1.34 Pain Relevance 0.73

OBJECTIVE: To study the expression of proliferation markers (ki-67) and anti-apoptotic protein (bcl-2) in adenomyotic lesions during the menstrual cycle or following the use of steroid hormones.

Negative_regulation (following) of Gene_expression (expression) of anti-apoptotic protein associated with dismenorea and apoptosis

9) Confidence 0.00 Published 2005 Journal Gynecol. Endocrinol. Section Abstract Doc Link 16019350 Disease Relevance 0.28 Pain Relevance 0.17

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