INT103977

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.38
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SPINK1)
SPINK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 467 100.00 Very High Very High Very High
Inflammation 31 99.84 Very High Very High Very High
fibrosis 64 92.24 High High
alcohol 24 71.80 Quite High
abdominal pain 9 46.00 Quite Low
imagery 13 43.20 Quite Low
Pain 24 31.40 Quite Low
Inflammatory response 1 20.52 Low Low
Bile 24 5.00 Very Low Very Low Very Low
Pain management 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 602 100.00 Very High Very High Very High
Targeted Disruption 36 99.98 Very High Very High Very High
INFLAMMATION 28 99.84 Very High Very High Very High
Cancer 30 99.04 Very High Very High Very High
Pancreatic Cancer 66 97.76 Very High Very High Very High
Disease 122 95.92 Very High Very High Very High
Nicotine Addiction 13 95.44 Very High Very High Very High
Cystic Fibrosis 49 92.24 High High
Colon Cancer 34 90.32 High High
Injury 12 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SPINK1 is an acute phase protein whose gene expression and protein concentrations are markedly upregulated by inflammation [16], [17], [18].
Positive_regulation (upregulated) of Gene_expression (expression) of SPINK1 associated with inflammation
1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 1.12 Pain Relevance 0.74
The indication for PRSS1 and SPINK1 mutation testing in symptomatic patients should be one of the following:
Positive_regulation (for) of Gene_expression (testing) of SPINK1
2) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.89 Pain Relevance 0.28
Transgenic expression of SPINK1 did not hinder trypsinogen activation, but reduced trypsin activity after supramaximal stimulation with cerulein.
Neg (not) Positive_regulation (hinder) of Gene_expression (expression) of SPINK1 associated with targeted disruption
3) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.76 Pain Relevance 0
The indication for PRSS1 and SPINK1 mutation testing in symptomatic patients should be one of the following:
Positive_regulation (indication) of Gene_expression (testing) of SPINK1
4) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.89 Pain Relevance 0.28
SPINK1 mutations in chronic pancreatitis
Positive_regulation (pancreatitis) of Gene_expression (mutations) of SPINK1 associated with chronic pancreatitis
5) Confidence 0.40 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.42 Pain Relevance 0.65
Three main mechanisms have been proposed to cause increased levels of TATI in serum; leakage from tumour-derived TATI into the circulation and as a response to tissue destruction and inflammation [16].
Positive_regulation (increased) of Gene_expression (levels) of TATI associated with inflammation and cancer
6) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.57 Pain Relevance 0.08
In 15 patients, we detected a PRSS1 mutation (8 with A16V, 5 with R122H, 2 with N29I), and in 34 patients, a SPINK1 mutation (30 with N34S, 4 with others).
Positive_regulation (detected) of Gene_expression (mutation) of SPINK1
7) Confidence 0.33 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120220 Disease Relevance 0.73 Pain Relevance 0.63

General Comments

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