INT103988

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 1.07
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mapk7) cytosol (Mapk7) nucleus (Mapk7)
cell cycle (Mapk7) cytoplasm (Mapk7)
Anatomy Link Frequency
dorsal horn 2
Mapk7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 6 100.00 Very High Very High Very High
excitatory amino acid 2 99.98 Very High Very High Very High
Neuropathic pain 9 98.92 Very High Very High Very High
gABA 4 98.84 Very High Very High Very High
Glutamate 2 97.92 Very High Very High Very High
Antinociceptive 2 96.60 Very High Very High Very High
Spinal cord 3 75.00 Quite High
Pain 10 25.00 Low Low
neuralgia 6 25.00 Low Low
nociceptor 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High
Neuropathic Pain 9 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate whether activation and translocation of extracellular signal-regulated kinase 5 (ERK5) is involved in the induction and maintenance of neuropathic pain and observe the effects of activation and translocation of ERK5 on the expression of phosphorylated cAMP response element binding (pCREB) in the chronic neuropathic pain.
Localization (translocation) of ERK5 associated with neuropathic pain
1) Confidence 0.71 Published 2009 Journal Neurol. Res. Section Abstract Doc Link 19426589 Disease Relevance 0.27 Pain Relevance 0.30
OBJECTIVE: To investigate whether activation and translocation of extracellular signal-regulated kinase 5 (ERK5) is involved in the induction and maintenance of neuropathic pain and observe the effects of activation and translocation of ERK5 on the expression of phosphorylated cAMP response element binding (pCREB) in the chronic neuropathic pain.
Localization (translocation) of extracellular signal-regulated kinase 5 associated with neuropathic pain
2) Confidence 0.71 Published 2009 Journal Neurol. Res. Section Abstract Doc Link 19426589 Disease Relevance 0.26 Pain Relevance 0.30
OBJECTIVE: To investigate whether activation and translocation of extracellular signal-regulated kinase 5 (ERK5) is involved in the induction and maintenance of neuropathic pain and observe the effects of activation and translocation of ERK5 on the expression of phosphorylated cAMP response element binding (pCREB) in the chronic neuropathic pain.
Localization (translocation) of ERK5 associated with neuropathic pain
3) Confidence 0.71 Published 2009 Journal Neurol. Res. Section Abstract Doc Link 19426589 Disease Relevance 0.27 Pain Relevance 0.31
In the present communication, we determined the dynamic release of amino acid transmitters from spinal dorsal horn induced by scorpion Buthus martensi Karsch (BmK) venom and a neurotoxin (BmK I).
Spec (determined) Localization (release) of BmK I in dorsal horn associated with spinal dorsal horn
4) Confidence 0.54 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 12121809 Disease Relevance 0.07 Pain Relevance 0.30
The result suggested that nociceptive afferent fibers could be activated to induce excitatory amino acid release from spinal dorsal horn by nociceptive factors such as BmK I, but the delayed release of GABA might be attributed to the modulating role of some antinociceptive components in the venom.
Localization (release) of BmK I in dorsal horn associated with nociception, gaba, spinal dorsal horn, antinociceptive and excitatory amino acid
5) Confidence 0.54 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 12121809 Disease Relevance 0.20 Pain Relevance 0.36

General Comments

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