INT103996

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 7.81
Pain Relevance 12.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
paw 4
dorsal horn 4
spinal 2
neck 2
spinal cord 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 105 100.00 Very High Very High Very High
ketamine 146 99.98 Very High Very High Very High
Thermal hyperalgesia 114 99.90 Very High Very High Very High
intrathecal 106 99.84 Very High Very High Very High
spinal dorsal horn 36 99.84 Very High Very High Very High
Eae 60 99.74 Very High Very High Very High
Hyperalgesia 241 99.48 Very High Very High Very High
Spinal cord 293 99.36 Very High Very High Very High
local anesthetic 2 99.24 Very High Very High Very High
Dorsal horn neuron 39 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 99 100.00 Very High Very High Very High
Hyperalgesia 361 99.90 Very High Very High Very High
Inflammatory Pain 42 99.74 Very High Very High Very High
Neuropathic Pain 160 98.70 Very High Very High Very High
Post Operative Pain 20 93.80 High High
Injury 56 91.04 High High
Nociception 135 88.64 High High
Pain 116 78.24 Quite High
Frailty 10 63.12 Quite High
Targeted Disruption 12 31.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, pretreated ketamine decreased the higher level of NR2B tyrosine phosphorylation in spinal dorsal horn caused by intraoperative infusion of remifentanil (P < 0.05).


Negative_regulation (decreased) of Phosphorylation (phosphorylation) of NR2B in spinal associated with ketamine, spinal dorsal horn and ultiva
1) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.14 Pain Relevance 0.97
The second finding is that pretreatment with ketamine, via inhibiting tyrosine phosphorylation of NR2B in superficial spinal cord of rats, attenuated exaggerated hyperalgesia induced by remifentanil.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with hyperalgesia, ketamine, ultiva and spinal cord
2) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.77 Pain Relevance 1.66
Correlated with the antihyperalgesic and antiallodynic effects of ketamine, in the present study immunocytochemical and western blotting experiment revealed pretreatment with ketamine 10 mg/kg reduced the higher level of NR2B tyrosine phosphorylation in spinal dorsal horn caused by remifentanil.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with antihyperalgesic, ketamine, spinal dorsal horn, ultiva and antiallodynic
3) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.61 Pain Relevance 1.67
Conversely, pretreatment of ketamine decreased the higher level of NR2B tyrosine phosphorylation in spinal dorsal horn caused by remifentanil (P < 0.01) (Figure 5).


Negative_regulation (decreased) of Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with ketamine, spinal dorsal horn and ultiva
4) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.36 Pain Relevance 1.30
The increase in NR2B tyrosine phosphorylation was dependent on primary afferent drive because (1) the phosphorylation correlated with the temporal profile of inflammation and hyperalgesia, (2) shorter-duration noxious stimulation produced a rapid and shorter-lasting increase in phosphorylation, and (3) local anesthetic block of the injected paw reversibly blocked inflammation-induced NR2B tyrosine phosphorylation and delayed hyperalgesia.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of NR2B in paw associated with hyperalgesia, inflammation and local anesthetic
5) Confidence 0.56 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 1.20 Pain Relevance 1.41
Intrathecal administration of the soluble Eph-B1 receptor chimera prior to the carrageenan injection significantly reduced the phosphorylation levels of NR2B (Fig. 3).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of NR2B associated with b1 receptor and intrathecal
6) Confidence 0.49 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.52 Pain Relevance 0.42
Sequestration of ephrinB2 following chronic inflammatory pain in the cord prevents the rise in NR2B phosphorylation
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of NR2B associated with eae
7) Confidence 0.49 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.58 Pain Relevance 0.43
This suggests that the interaction of endogenous ephrin with EphB receptors on dorsal horn neurons was prevented by the soluble receptor, hence preventing the phosphorylation of NR2B induced by carrageenan.


Negative_regulation (preventing) of Phosphorylation (phosphorylation) of NR2B in neurons associated with dorsal horn neuron
8) Confidence 0.49 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.46 Pain Relevance 0.43
Both the behavioral thermal hyperalgesia and NR2B phosphorylation were inhibited in a dose-dependent manner in the present work by preceding ephrinB2-Fc injection with injection of the Src family inhibitor PP2.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of NR2B associated with thermal hyperalgesia
9) Confidence 0.49 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.39 Pain Relevance 0.64
We also showed that blockage of endogenous EphB receptor activation by intrathecal injection with EphB1-Fc chimeras, which we had previously shown to inhibit the behavioral and thermal hyperalgesia induced by carrageenan injection in the hind paw (Battaglia et al., 2003), also inhibited the phosphorylation of NR2B induced by this injection.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of NR2B in paw associated with thermal hyperalgesia and intrathecal
10) Confidence 0.49 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.31 Pain Relevance 0.45
The BAPTA injection decreased significantly the mean integrated optical density of phosphorylated NR1 subunit in the superficial laminae and neck region, and the phosphorylated NR2B subunit in the superficial laminae.
Negative_regulation (decreased) of Phosphorylation (phosphorylated) of NR2B in neck
11) Confidence 0.43 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.55
The NR2B phosphorylation was blocked by inhibitors of Src type kinases.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of NR2B
12) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.62 Pain Relevance 0.80
Indeed, EphB1-Fc administration, which competes with the endogenous receptor for ephrinB2 binding and prevents behavioral allodynia and hyperalgesia in the carrageenan model of inflammation, also inhibited NR2B phosphorylation in this model.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of NR2B associated with hyperalgesia, inflammation and allodynia
13) Confidence 0.36 Published 2008 Journal Neuroscience Section Abstract Doc Link PMC2568875 Disease Relevance 0.66 Pain Relevance 0.68
The increase in NR2B tyrosine phosphorylation was abolished by intrathecal pretreatment with genistein, a tyrosine kinase inhibitor; PP2, an Src family tyrosine kinase inhibitor; AIDA, a group I metabotropic glutamate receptor antagonist; L733,060, an NK1 tachykinin receptor antagonist, and chelerythrine, a protein kinase C inhibitor.
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of NR2B associated with antagonist, glutamate receptor, kinase c inhibitor and intrathecal
14) Confidence 0.36 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 1.19 Pain Relevance 1.43

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