INT103997

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Context Info
Confidence 0.64
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.75
Pain Relevance 12.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
spinal 1
RVM 1
tails 1
neurons 1
paw 1
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 7 99.84 Very High Very High Very High
Inflammation 187 99.66 Very High Very High Very High
Spinal cord 336 99.64 Very High Very High Very High
Anterior cingulate cortex 16 99.42 Very High Very High Very High
nMDA receptor 361 99.30 Very High Very High Very High
Thermal hyperalgesia 96 98.60 Very High Very High Very High
Pain 125 97.68 Very High Very High Very High
Arthritis 30 97.48 Very High Very High Very High
Stimulus evoked pain 3 96.32 Very High Very High Very High
amygdala 56 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 184 99.66 Very High Very High Very High
Nociception 234 99.40 Very High Very High Very High
Injury 114 99.24 Very High Very High Very High
Hyperalgesia 240 98.60 Very High Very High Very High
Pain 182 97.68 Very High Very High Very High
Arthritis 30 97.48 Very High Very High Very High
Hypersensitivity 4 96.32 Very High Very High Very High
Inflammatory Pain 17 92.44 High High
Targeted Disruption 6 91.76 High High
Neuropathic Pain 170 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We did not detect any differences in immunoreactivity in any of the non-phosphorylated NR1, NR2A, NR2B, NR2C or the NR2D subunits.
Phosphorylation (phosphorylated) of NR2A
1) Confidence 0.64 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16469445 Disease Relevance 0.94 Pain Relevance 0.75
In this study we used a relatively long lasting nociceptive stimulus to evaluate NR1 and NR2 subunit phosphorylation and protein expression.
Phosphorylation (phosphorylation) of NR2 associated with nociception
2) Confidence 0.62 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.83 Pain Relevance 0.75
The inflammation did not produce phosphorylation of serines on NR2 subunits or phosphorylation of threonine and tyrosine residues on either NR1 or NR2 subunits.
Phosphorylation (phosphorylation) of NR2 associated with inflammation
3) Confidence 0.61 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 1.06 Pain Relevance 0.81
The inflammation did not produce phosphorylation of serines on NR2 subunits or phosphorylation of threonine and tyrosine residues on either NR1 or NR2 subunits.
Phosphorylation (phosphorylation) of NR2 associated with inflammation
4) Confidence 0.61 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.96 Pain Relevance 0.70
Interestingly, NR2A was reported not to be phosphorylated following the CFA injury.
Neg (not) Phosphorylation (phosphorylated) of NR2A associated with injury
5) Confidence 0.54 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.66 Pain Relevance 0.81
An examination of phosphorylation of NR2A (N = 5 rats/time point) and NR2B (N = 9 rats/time point) demonstrated that there was no significant change in phosphorylation on serine residues (Figure 5A) (ANOVA on raw data, p > 0.05) after carrageenan treatment.
Phosphorylation (phosphorylation) of NR2A
6) Confidence 0.54 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0 Pain Relevance 0.11
Western blot and immunohistochemistry were performed to determine changes in Sig-1R expression and to examine the effect of BD1047 on N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation in spinal cord dorsal horn from neuropathic rats.
Phosphorylation (phosphorylation) of N-methyl-D-aspartate receptor subunit 1 in spinal cord dorsal horn
7) Confidence 0.52 Published 2008 Journal Anesthesiology Section Body Doc Link 18946301 Disease Relevance 0.16 Pain Relevance 0
Likewise, no NR2 subunit phosphorylation was observed on serine, threonine or tyrosine residues.
Phosphorylation (phosphorylation) of NR2
8) Confidence 0.47 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1208948 Disease Relevance 0.62 Pain Relevance 0.53
In this study the role of phosphorylation of NR1 splice variants and NR2 subunits was examined following hind paw inflammation in rats.
Phosphorylation (phosphorylation) of NR2 in paw associated with inflammation
9) Confidence 0.47 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1208948 Disease Relevance 0.35 Pain Relevance 0.35
Although both NR2A and NR2B subunits can be tyrosine phosphorylated in vitro, studies have showed that tyrosine phosphorylation of the NR2B subunits play a key role in the NMDA receptor activation, and contribute to nociceptor activity induced spinal plasticity and the development of central sensitization [30].
Phosphorylation (phosphorylated) of NR2A in spinal associated with central sensitization, nociceptor and nmda receptor
10) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.60 Pain Relevance 1.08
Importantly, BD1047 (30 nmol) administered intrathecally during the induction, but not the maintenance phase, blocked the CCI-induced increase in N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation.
Phosphorylation (phosphorylation) of N-methyl-D-aspartate receptor subunit 1
11) Confidence 0.45 Published 2008 Journal Anesthesiology Section Body Doc Link 18946301 Disease Relevance 0.05 Pain Relevance 0
Indeed, EphB2 activation of Src by phosphorylation in cultured hippocampal and cortical neurons could induce NR2A phosphorylation (Grunwald et al., 2001).
Phosphorylation (phosphorylation) of NR2A in neurons
12) Confidence 0.44 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.15 Pain Relevance 0.33
NR2 is tyrosine phosphorylated at its C-terminal tails by Src-family tyrosine kinases, such as Src, Fyn [28,29].
Phosphorylation (phosphorylated) of NR2 in tails
13) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.64 Pain Relevance 1.18
Compared with naive rats, there was a rapid and prolonged increase in tyrosine phosphorylation of the NR2B, but not NR2A, subunit after inflammation.
Phosphorylation (phosphorylation) of NR2A associated with inflammation
14) Confidence 0.41 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 0.97 Pain Relevance 0.94
However NR2A phosphorylation was unchanged following complete Freund's adjuvant-induced noxious stimulation, suggesting it is unlikely that this subunit has a role in hyperalgesia (Guo et al., 2002).
Phosphorylation (phosphorylation) of NR2A associated with hyperalgesia
15) Confidence 0.38 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.16 Pain Relevance 0.34
Hindpaw inflammation increased the expression of NR2B, but not NR1 or NR2A, in the ACC [32] and increased tyrosine phosphorylation of NR2B, but not NR2A, in the spinal cord [34,35] but not ACC [32].
Phosphorylation (phosphorylation) of NR2A in ACC associated with inflammation, anterior cingulate cortex and spinal cord
16) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2679723 Disease Relevance 1.11 Pain Relevance 1.90
NMDA receptor function can be modulated through phosphorylation of NR1 or NR2 subunits by various kinases, including PKA, PKC, ERK and tyrosine kinase [7,13-17].
Phosphorylation (phosphorylation) of NR2 associated with nmda receptor
17) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2679723 Disease Relevance 0.57 Pain Relevance 0.99
In vitro studies with RVM slices show that BDNF induces tyrosine phosphorylation of the NMDAR NR2A subunit in RVM via a signal transduction cascade involving IP(3), PKC, and Src.
Phosphorylation (phosphorylation) of NMDAR NR2A subunit in RVM associated with rostral ventromedial medulla
18) Confidence 0.01 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399679 Disease Relevance 0.92 Pain Relevance 1.10

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