INT103998

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 42
Disease Relevance 19.08
Pain Relevance 36.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 16
paw 8
PP2A 6
dorsal horn 6
spinal 4
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 709 100.00 Very High Very High Very High
nMDA receptor 591 100.00 Very High Very High Very High
Ultiva 550 100.00 Very High Very High Very High
Dorsal horn 276 100.00 Very High Very High Very High
spinal dorsal horn 90 100.00 Very High Very High Very High
qutenza 18 100.00 Very High Very High Very High
Inflammation 236 99.98 Very High Very High Very High
Thermal hyperalgesia 278 99.96 Very High Very High Very High
Eae 160 99.84 Very High Very High Very High
Hyperalgesia 608 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 212 99.98 Very High Very High Very High
Hyperalgesia 902 99.96 Very High Very High Very High
Inflammatory Pain 112 99.84 Very High Very High Very High
Post Operative Pain 50 99.60 Very High Very High Very High
Pain 271 99.46 Very High Very High Very High
Neuropathic Pain 387 99.16 Very High Very High Very High
Stress Incontinence 9 98.44 Very High Very High Very High
Complex Regional Pain Syndromes 3 93.52 High High
Functional Bowel Disorder 3 92.76 High High
Nociception 284 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of NR2B tyrosine phosphorylation in rats receiving intraoperative remifentanil infusion was significantly upregulated when compared with rats receiving intraoperative saline infusion (P < 0.01).
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of NR2B associated with ultiva
1) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.23 Pain Relevance 1.14
The first one is that hyperalgesia induced by remifentanil in a rat model of postoperative pain associated with an enhancement of tyrosine phosphorylation of NR2B in superficial spinal cord.
Positive_regulation (enhancement) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with hyperalgesia, perioperative pain, ultiva and spinal cord
2) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.67 Pain Relevance 1.59
When compared with rats receiving sevoflurane and saline in the absence of surgery, the right hind paw plantar incision increased the level of NR2B tyrosine phosphorylation in the spinal dorsal cord (P < 0.01).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of NR2B in spinal
3) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.20 Pain Relevance 1.07
The expression of NR2B tyrosine phosphorylation in the superficial dorsal horn of the group I, K, R, K+R was increased when compared to group C (P < 0.01).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with dorsal horn
4) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.36 Pain Relevance 1.22
The increase in NR2B tyrosine phosphorylation was dependent on primary afferent drive because (1) the phosphorylation correlated with the temporal profile of inflammation and hyperalgesia, (2) shorter-duration noxious stimulation produced a rapid and shorter-lasting increase in phosphorylation, and (3) local anesthetic block of the injected paw reversibly blocked inflammation-induced NR2B tyrosine phosphorylation and delayed hyperalgesia.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR2B in paw associated with hyperalgesia, inflammation and local anesthetic
5) Confidence 0.66 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 1.20 Pain Relevance 1.40
Compared with naive rats, there was a rapid and prolonged increase in tyrosine phosphorylation of the NR2B, but not NR2A, subunit after inflammation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR2B associated with inflammation
6) Confidence 0.66 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 0.97 Pain Relevance 0.94
We found that the upregulated phosphorylation of both NR1 and NR2B subunits induced by capsaicin injection was significantly potentiated by the PP2A inhibitor without affecting the NR1 and NR2B protein itself.
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of NR2B in PP2A associated with qutenza
7) Confidence 0.58 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15919130 Disease Relevance 0 Pain Relevance 0.86
This suggests that the interaction of endogenous ephrin with EphB receptors on dorsal horn neurons was prevented by the soluble receptor, hence preventing the phosphorylation of NR2B induced by carrageenan.


Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR2B in neurons associated with dorsal horn neuron
8) Confidence 0.58 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.46 Pain Relevance 0.43
We first showed that intrathecal injection of ephrinB2-Fc chimeras, which induces thermal hyperalgesia, also induced NR2B phosphorylation on one or more tyrosine residues, including tyrosine 1472.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR2B associated with thermal hyperalgesia and intrathecal
9) Confidence 0.58 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.58 Pain Relevance 0.93
We also showed that blockage of endogenous EphB receptor activation by intrathecal injection with EphB1-Fc chimeras, which we had previously shown to inhibit the behavioral and thermal hyperalgesia induced by carrageenan injection in the hind paw (Battaglia et al., 2003), also inhibited the phosphorylation of NR2B induced by this injection.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR2B in paw associated with thermal hyperalgesia and intrathecal
10) Confidence 0.58 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.30 Pain Relevance 0.47
Sequestration of ephrinB2 following chronic inflammatory pain in the cord prevents the rise in NR2B phosphorylation
Positive_regulation (rise) of Phosphorylation (phosphorylation) of NR2B associated with eae
11) Confidence 0.58 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.57 Pain Relevance 0.43
The increase in NR2B tyrosine phosphorylation was abolished by intrathecal pretreatment with genistein, a tyrosine kinase inhibitor; PP2, an Src family tyrosine kinase inhibitor; AIDA, a group I metabotropic glutamate receptor antagonist; L733,060, an NK1 tachykinin receptor antagonist, and chelerythrine, a protein kinase C inhibitor.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR2B associated with antagonist, glutamate receptor, kinase c inhibitor and intrathecal
12) Confidence 0.58 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 1.19 Pain Relevance 1.43
The increase in NR2B tyrosine phosphorylation was dependent on primary afferent drive because (1) the phosphorylation correlated with the temporal profile of inflammation and hyperalgesia, (2) shorter-duration noxious stimulation produced a rapid and shorter-lasting increase in phosphorylation, and (3) local anesthetic block of the injected paw reversibly blocked inflammation-induced NR2B tyrosine phosphorylation and delayed hyperalgesia.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR2B in paw associated with hyperalgesia, inflammation and local anesthetic
13) Confidence 0.58 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 1.02 Pain Relevance 1.02
At 60 min after the termination of EA stimulation, the levels of c-fos, serine phosphorylation of NR1 and NR2B by Western analysis had increased in the L(4-5) segments of the spinal cord after EA treatment.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with electroacupuncture and spinal cord
14) Confidence 0.56 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.79
Src phosphorylation is required for phosphorylation of the NR2B subunit of the NMDA receptor and for induction of thermal hyperalgesia by ephrinB2.
Positive_regulation (required) of Phosphorylation (phosphorylation) of NR2B associated with thermal hyperalgesia and nmda receptor
15) Confidence 0.51 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.98 Pain Relevance 0.93
Administration of PP2, which inhibits the Src family of protein tyrosine kinases, prior to administration of ephrinB2, prevented the increase in NR2B tyrosine phosphorylation (Fig. 1A lane 3 vs. lane 1 and 2).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR2B
16) Confidence 0.51 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.12 Pain Relevance 0.21
These findings correlate in vivo NMDA receptor tyrosine phosphorylation with the development and maintenance of inflammatory hyperalgesia and suggest that signal transduction upstream to NR2B tyrosine phosphorylation involves G-protein-coupled receptors and PKC and Src family protein tyrosine kinases.
Positive_regulation (involves) of Phosphorylation (phosphorylation) of NR2B associated with hyperalgesia, inflammation and nmda receptor
17) Confidence 0.48 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 0.87 Pain Relevance 1.13
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of NR2B in descending colon associated with action potential and spinal cord
18) Confidence 0.48 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.46
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of pNR2B in descending colon associated with action potential and spinal cord
19) Confidence 0.48 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.46
This study showed that the expression of NR2B tyrosine phosphorylation in the spinal dorsal horn increases markedly during the maintenance of the hyreralgesia induced by remifentanil and this increase can be prevented by pretreatment with ketamine.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with ketamine, spinal dorsal horn and ultiva
20) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.12 Pain Relevance 1.11

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